Results 1 to 10 of about 2,611 (169)

Withanolides-induced breast cancer cell death is correlated with their ability to inhibit heat protein 90.

open access: yesPLoS ONE, 2012
Withanolides are a large group of steroidal lactones found in Solanaceae plants that exhibit potential anticancer activities. We have previously demonstrated that a withanolide, tubocapsenolide A, induced cycle arrest and apoptosis in human breast cancer
Hui-Chun Wang   +6 more
doaj   +2 more sources

Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides

open access: yesMolecules, 2022
Natural products are a major source of biologically active compounds that make promising lead molecules for developing efficacious drug-like molecules.
Amandeep Singh   +4 more
doaj   +2 more sources

Pharmacokinetics and bioequivalence of Withania somnifera (Ashwagandha) extracts – A double blind, crossover study in healthy adults

open access: yesHeliyon, 2023
Introduction: Withania somnifera (WS) or ashwagandha is an adaptogenic plant used extensively in traditional medicines and as a food supplement. Despite a long history of use and numerous clinical trials, the human pharmacokinetics of withanolides, the ...
Se-Kwon Kim   +3 more
doaj   +1 more source

Pharmacokinetic Study of Withanosides and Withanolides from Withania somnifera Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS)

open access: yesMolecules, 2022
Withania somnifera is a traditional Indian herb described under the ‘Rasayana’ class in Ayurveda, which gained immense popularity as a dietary supplement in the USA, Europe, Asia, and the Indian domestic market.
Siddharth J. Modi   +9 more
doaj   +1 more source

QUANTITIVE EVOLUTION OF WITHANOLIDES CONTENT OF EGYPTIAN WITHANIA SOMNIFERA (L.) ROOTS. [PDF]

open access: yesAl-Azhar Journal of Pharmaceutical Sciences, 2013
Withanolides are important secondary metabolite in Withania somnifera (L.), which have high medicinal values and possess potent anti-tumor and antioxidant properties.
Said Ismail
doaj   +1 more source

Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. [PDF]

open access: yesPLoS ONE, 2014
The present study investigated the biosynthesis of major and minor withanolides of Withania somnifera in cell suspension culture using shake-flask culture and bioreactor by exploiting elicitation and precursor feeding strategies.
Ganeshan Sivanandhan   +3 more
doaj   +1 more source

Genetic analysis for yield and quality contributing parameters in ashwagandha [Withania somnifera (L.) Dunal]

open access: yesElectronic Journal of Plant Breeding, 2023
Fourty-eight ashwagandha [Withania somnifera (L.) Dunal] genotypes were studied for the genetic variability, heritability and trait association during 2018-19 based on 13 yield and quality traits. For all the 13 characters studied, highly significant
Venna Santhosh1,3*, B. Prem Kumar2 , B. Pratibha3 , L. Sampath4 and Akarsh Parihar3
doaj   +1 more source

Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2020
Withania somnifera L. is a multipurpose medicinal plant of family Solanaceae occurring abundantly in sub-tropical regions of the world. The folk healers used the plant to treat several diseases such as fever, cancer, asthma, diabetes, ulcer, hepatitis ...
Sumaira Saleem   +4 more
doaj   +1 more source

Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway

open access: yesMolecules, 2019
Psoriasis is an immune-mediated inflammatory dermatosis characterized by epidermal hyperplasia and excessive infiltration of inflammatory cells. Withanolides, extracted from Datura metel L.; are the main effective components for the treatment of ...
Tingting Li   +4 more
doaj   +1 more source

Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera)

open access: yesJournal of Ginseng Research, 2022
Background: Withania somnifera (Solanaceae), generally known as Indian ginseng, is a medicinal plant that is used in Ayurvedic practice for promoting health and longevity.
Seoung Rak Lee   +10 more
doaj   +1 more source

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