Results 1 to 10 of about 1,755 (175)

Anxiolytic and Memory Protective Effects of Withanolide D Isolated From Acnistus arborescens in Adult Zebrafish. [PDF]

Chem Biodivers
Withanolide D Exhibits Anxiolytic and Memory‐Protective Effects. ABSTRACT This study evaluated the anxiolytic and memory‐protective effects of withanolide D in adult zebrafish (Danio rerio). The compound was administered at doses of 4, 20, and 40 mg/kg and showed no signs of toxicity after 96 h of observation at any of the doses tested.
de Sousa Feitosa CR, Alves Da Silva J, Maciel JB, Romão IC, Cavalcante TR, Barros FAN, de Abreu Bandeira N, Marinho ES, Menezes JESA, Ferreira MKA, Wlisses Da Silva A, Marinho MM, Rocha MND, Pessoa ODL, Batista PHJ, De Castro Gomes AF, Teixeira AMR, Dos Santos HS.   +17 more
europepmc   +2 more sources

Anticancer Effects of Withanolides: In Silico Prediction of Pharmacological Properties [PDF]

Molecules
Withanolides are a class of naturally occurring C-28 ergostane steroidal lactones with an abundance of biological activities, and their members are promising candidates for antineoplastic drug development.
Gustavo Werneck de Souza e Silva, André Mesquita Marques, André Luiz Franco Sampaio   +2 more
doaj   +2 more sources

Cytotoxic Potential Evaluation of Innovative Pressurised Cyclic Solid–Liquid Extracts from Withania somnifera [PDF]

Plants
Ethnopharmacological relevance. Withania somnifera (L.) Dunal, widely used in traditional medical systems such as Ayurveda, Unani, and Middle Eastern folk medicine, is valued for its adaptogenic, anti-inflammatory, neuroprotective, antimicrobial, and ...
Rosanna Culurciello, Karen Power, Sergio Esposito, Ilaria Di Nardo, Simone Landi, Gionata De Vico, Domenico Palatucci, Elio Pizzo, Daniele Naviglio, Armando Zarrelli   +9 more
doaj   +2 more sources

Metabolism of Epoxidised Withanolides by a Generalist and a Specialist Insect Species [PDF]

ChemistryOpen
Major secondary metabolites of Physalis plants, epoxidized withanolides, have a potent feeding deterrent and growth inhibitory effect on most herbivorous insects.
Marie Pauline Sell, Christian Paetz, Felix Feistel, David G. Heckel, Yannick Pauchet   +4 more
doaj   +2 more sources

Withanolides from Withania coagulans

Phytochemistry, 2003
Two withanolides, 20beta-hydroxy-1-oxo-(22R)-witha-2,5,24-trienolide (1) and withacoagulin (2), along with a known withanolide, 17beta-hydroxy-14alpha, 20alpha-epoxy-1-oxo-(22R)-witha-3,5,24-trienolide (3) were isolated from Withania coagulans. Their structures were elucidated with the help of different spectroscopic techniques.
M Iqbal Choudhary, M․Iqbal Choudhary
exaly   +6 more sources

Nutraceutical Applications of Withania somnifera: The Scientific Knowledge for Rational Modern Use of the “Ayurvedic Adaptogen” [PDF]

Foods
Withania somnifera L. (Dunal), commonly known as Ashwagandha, is widely used in traditional medical systems, particularly Ayurveda, and is increasingly included in nutraceuticals and dietary supplements.
Sudip Pandey, Poonam Pant, Giovanni Corbioli, Erica Bonazzi, Miluska Cisneros-Yupanqui, Paola Salmaso, Stefano Dall’Acqua   +6 more
doaj   +2 more sources

Ultrasound-assisted extraction of withanolides from Tubocapsicum anomalum: Process optimization, isolation and identification, and antiproliferative activity [PDF]

Ultrasonics Sonochemistry
Tubocapsicum anomalum, a Chinese medicinal plant rich in anti-tumor withanolides, requires efficient extraction methods. In this paper, an HPLC method was first established for the detection of withanolides, and gradient elution was carried out using a ...
Ke Xiang, Rui Zhu, Yueying Yang, Yang Xu, Kuiru Sa, Hua Li, Lixia Chen   +6 more
doaj   +2 more sources

Enhancing Withanolide Production in the Withania Species: Advances in In Vitro Culture and Synthetic Biology Approaches [PDF]

Plants
Withanolides are naturally occurring steroidal lactones found in certain species of the Withania genus, especially Withania somnifera (commonly known as Ashwagandha).
Zishan Ahmad, Shareen, Irfan Bashir Ganie, Fatima Firdaus, Muthusamy Ramakrishnan, Anwar Shahzad, Yulong Ding   +6 more
doaj   +2 more sources

Randomized, Double-Blind, Crossover Study Comparing the Bioavailability of 4 Ashwagandha (Withania somnifera (L.) Dunal) Extracts in Healthy Adults Under Fasting Condition [PDF]

Current Therapeutic Research
Background: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is a well-known plant in ayurvedic medicine, widely valued for its therapeutic potential. Although numerous clinical studies have explored its diverse health benefits, limited data
Priyank Rathi, MD, Se-Kwon Kim, PhD
doaj   +2 more sources

A Novel Ashwagandha (Withania somnifera) Formulation Mitigates Sleep Deprivation-Induced Cognitive Impairment and Oxidative Stress in a Rat Model [PDF]

Biomolecules
Ashwagandha (Withania somnifera) is a well-known adaptogenic herb traditionally used to enhance sleep quality and mitigate stress-induced cognitive decline.
Besir Er, Busra Ozmen, Emre Sahin, Cemal Orhan, Nurhan Sahin, Abhijeet A. Morde, Muralidhara Padigaru, Kazim Sahin   +7 more
doaj   +2 more sources