Results 11 to 20 of about 2,412 (209)

Withanolides and Related Steroids [PDF]

, 2011
Since the isolation of the first withanolides in the mid-1960s, over 600 new members of this group of compounds have been described, with most from genera of the plant family Solanaceae. The basic structure of withaferin A, a C28 ergostane with a modified side chain forming a δ-lactone between carbons 22 and 26, was considered for many years the basic ...
Misico, Rosana Isabel, Nicotra, Viviana Estela, Oberti, Juan Carlos María, Barboza, Gloria Estela, Gil, Roberto Ricardo, Burton, Gerardo   +5 more
openaire   +4 more sources

Indirect regeneration of Withania somnifera and comparative analysis of withanolides in in vitro and greenhouse grown plants

Biologia Plantarum, 2010
The present study reports an efficient protocol for indirect shoot organogenesis and plantlets regeneration of Withania somnifera (L.) Dunal. Leaf explants were cultured on Murashige and Skoog (MS) medium supplemented with different concentrations and ...
Y. H. Dewir, D. Chakrabarty, S. -H. Lee, E. -J. Hahn, K. -Y. Paek   +4 more
doaj   +2 more sources

Withanolides-induced breast cancer cell death is correlated with their ability to inhibit heat protein 90.

PLoS ONE, 2012
Withanolides are a large group of steroidal lactones found in Solanaceae plants that exhibit potential anticancer activities. We have previously demonstrated that a withanolide, tubocapsenolide A, induced cycle arrest and apoptosis in human breast cancer
Hui-Chun Wang, Yi-Ling Tsai, Yang-Chang Wu, Fang-Rong Chang, Mei-Hsin Liu, Wen-Ying Chen, Chin-Chung Wu   +6 more
doaj   +2 more sources

Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically Grown Physalis coztomatl

Molecules, 2022
Withanolides constitute one of the most interesting classes of natural products due to their diversity of structures and biological activities. Our recent studies on withanolides obtained from plants of Solanaceae including Withania somnifera and a ...
Ya-Ming Xu, E. M. Kithsiri Wijeratne, Manping X. Liu, Lijiang Xuan, Wenqiong Wang, A. A. Leslie Gunatilaka   +5 more
doaj   +2 more sources

Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides

Molecules, 2022
Natural products are a major source of biologically active compounds that make promising lead molecules for developing efficacious drug-like molecules.
Amandeep Singh, Asif Raza, Shantu Amin, Chendil Damodaran, Arun K. Sharma   +4 more
doaj   +2 more sources

Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L. [PDF]

Beilstein Journal of Organic Chemistry, 2019
Withanolides are steroidal lactones widespread in Nightshade plants with often potent antiproliferative activities. Additionally, the structural diversity of this compound class holds much potential for the discovery of novel biological activity.
Annika Stein, Dave Compera, Bianka Karge, Mark Brönstrup, Jakob Franke   +4 more
doaj   +2 more sources

Chlorinated withanolides from Withania somnifera [PDF]

Phytochemistry Letters, 2011
A chlorinated withanolide, 6α-chloro-5β,17α-dihydroxywithaferin A (1), and nine known withanolides, 6α-chloro-5β-hydroxywithaferin A (2), (22R)-5β-formyl-6β,27-dihydroxy-1-oxo-4-norwith-24-enolide, withaferin A, 2,3-dihydrowithaferin A, 3-methoxy-2,3-dihydrowithaferin A, 2,3-didehydrosomnifericin, withanone, withanoside IV and withanoside X, were ...
Tong, Xiaoqin, Zhang, Huaping, Timmermann, Barbara N.   +2 more
openaire   +4 more sources

Leishmanicidal Activity of Withanolides from Aureliana Fasciculata var. Fasciculata

Molecules, 2018
Leishmaniasis is the generic denomination to the neglected diseases caused by more than 20 species of protozoa belonging to the genus Leishmania. The toxic and parenteral-delivered pentavalent antimonials remain to be the first-line treatment.
Simone Cristina de M. Lima, Juliana da Silva Pacheco, André M. Marques, Eduardo Raul Pereira Veltri, Rita de Cássia Almeida-Lafetá, Maria Raquel Figueiredo, Maria Auxiliadora Coelho Kaplan, Eduardo Caio Torres-Santos   +7 more
doaj   +2 more sources

Cytotoxic Withanolides from the Whole Herb of Physalis angulata L.

Molecules, 2019
Physalis angulata L. is a medicinal plant of the Solanaceae family, which is used to produce a variety of steroids. The present study reports on the cytotoxic withanolides of this plant. The species of Physalis angulata L. was identified by DNA barcoding
Qinghong Meng, Jiajia Fan, Zhiguo Liu, Xiwen Li, Fangbo Zhang, Yanlin Zhang, Yi Sun, Li Li, Xia Liu, Erbing Hua   +9 more
doaj   +2 more sources

Anxiolytic and Memory Protective Effects of Withanolide D Isolated From Acnistus arborescens in Adult Zebrafish. [PDF]

Chem Biodivers
Withanolide D Exhibits Anxiolytic and Memory‐Protective Effects. ABSTRACT This study evaluated the anxiolytic and memory‐protective effects of withanolide D in adult zebrafish (Danio rerio). The compound was administered at doses of 4, 20, and 40 mg/kg and showed no signs of toxicity after 96 h of observation at any of the doses tested.
de Sousa Feitosa CR, Alves Da Silva J, Maciel JB, Romão IC, Cavalcante TR, Barros FAN, de Abreu Bandeira N, Marinho ES, Menezes JESA, Ferreira MKA, Wlisses Da Silva A, Marinho MM, Rocha MND, Pessoa ODL, Batista PHJ, De Castro Gomes AF, Teixeira AMR, Dos Santos HS.   +17 more
europepmc   +2 more sources