Anticancer Effects of Withanolides: In Silico Prediction of Pharmacological Properties [PDF]
MoleculesWithanolides are a class of naturally occurring C-28 ergostane steroidal lactones with an abundance of biological activities, and their members are promising candidates for antineoplastic drug development.
Gustavo Werneck de Souza e Silva +2 more
doaj +3 more sources
Biologia Plantarum, 2010 The present study reports an efficient protocol for indirect shoot organogenesis and plantlets regeneration of Withania somnifera (L.) Dunal. Leaf explants were cultured on Murashige and Skoog (MS) medium supplemented with different concentrations and ...
Y. H. Dewir +4 more
doaj +2 more sources
Molecules, 2022 Withanolides constitute one of the most interesting classes of natural products due to their diversity of structures and biological activities. Our recent studies on withanolides obtained from plants of Solanaceae including Withania somnifera and a ...
Ya-Ming Xu +5 more
doaj +2 more sources
Withanolides Are Detected in Human Urine Following Oral Administration of a Withania somnifera Product [PDF]
Int J Mol SciAshwagandha (Withania somnifera (L.) Dunal; WS) is an adaptogenic herb, widely used in botanical dietary supplements. Plasma pharmacokinetics of selected withanolides, an important group of bioactive phytochemicals found in WS, have been described but no
Sarah A. Barr +9 more
core +2 more sources
Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L. [PDF]
Beilstein Journal of Organic Chemistry, 2019 Withanolides are steroidal lactones widespread in Nightshade plants with often potent antiproliferative activities. Additionally, the structural diversity of this compound class holds much potential for the discovery of novel biological activity.
Annika Stein +4 more
doaj +2 more sources
Cytotoxic Potential Evaluation of Innovative Pressurised Cyclic Solid–Liquid Extracts from Withania somnifera [PDF]
PlantsEthnopharmacological relevance. Withania somnifera (L.) Dunal, widely used in traditional medical systems such as Ayurveda, Unani, and Middle Eastern folk medicine, is valued for its adaptogenic, anti-inflammatory, neuroprotective, antimicrobial, and ...
Rosanna Culurciello +9 more
doaj +2 more sources
Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review [PDF]
Phytotherapy Research, Volume 40, Issue 8, Page 4792-4801, August 2026.ABSTRACT The preclinical evidence for the safety of ashwagandha ( Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports. Most studies and reviews conclude
Elizabeth M. Williamson, Thomas Brendler
wiley +2 more sources
Metabolism of Epoxidised Withanolides by a Generalist and a Specialist Insect Species [PDF]
ChemistryOpenMajor secondary metabolites of Physalis plants, epoxidized withanolides, have a potent feeding deterrent and growth inhibitory effect on most herbivorous insects.
Marie Pauline Sell +4 more
doaj +2 more sources
Chimpanzee-Guided Discovery of a Non-Native Bioactive Plant [PDF]
AnimalsStudies on chimpanzees suggest that some plants are consumed for their biological properties. Low frequency of consumption, small ingested quantities, complex food processing for a low nutritional value, and local ecological knowledge from human ...
Sabrina Krief +8 more
doaj +2 more sources
Nutraceutical Applications of Withania somnifera: The Scientific Knowledge for Rational Modern Use of the “Ayurvedic Adaptogen” [PDF]
FoodsWithania somnifera L. (Dunal), commonly known as Ashwagandha, is widely used in traditional medical systems, particularly Ayurveda, and is increasingly included in nutraceuticals and dietary supplements.
Sudip Pandey +6 more
doaj +2 more sources