Results 31 to 40 of about 2,412 (209)
Biomedicines, 2020 Acute myeloid leukemia (AML) is an aggressive disease and, despite advances, its treatment remains challenging. Therefore, it remains important to identify new agents for the management of this disease.
Nosheen Akhtar +4 more
doaj +1 more source
Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera)
Journal of Ginseng Research, 2022 Background: Withania somnifera (Solanaceae), generally known as Indian ginseng, is a medicinal plant that is used in Ayurvedic practice for promoting health and longevity.
Seoung Rak Lee +10 more
doaj +1 more source
Evaluating anticancer properties of Withaferin A—a potent phytochemical
Frontiers in Pharmacology, 2022 Withaferin A is a C28 steroidal lactone derived from the plant Withania somnifera, commonly known as Ashwagandha. Withaferin A has received great attention for its anticancer properties noted in cancer cells of various origins.
Maushma Atteeq
doaj +1 more source
Cells, 2022 Oxidative stress and the AKT serine/threonine kinase (AKT) signaling pathway are essential regulators in cellular migration, metastasis, and angiogenesis.
Jen-Yang Tang +6 more
doaj +1 more source
Withanolides from Jaborosa caulescens var. bipinnatifida [PDF]
, 2013 Two new withanolides 2,3-dihydrotrechonolide A (1) and 2,3-dihydro-21-hydroxytrechonolide A (2) were isolated along with two known withanolides trechonolide A (3) and jaborosalactone 39 (4) from Jaborosa caulescens var. bipinnatifida (Solanaceae).
Timmermann, Barbara N. +6 more
core +1 more source
Phytotoxic withanolides from Jaborosa rotacea [PDF]
, 2006 Twelve new withanolides were isolated from the aerial part of Jaborosa rotacea: five had a spiranoid delta-lactone ( 1- 5); one contained a 26,12-delta-lactone and a C-12-C-23 bond ( 6); five corresponded to trechonolide-type withanolides with ...
Feresin, Gabriela Egly +13 more
core +3 more sources
Antiproliferative Withanolides from Datura wrightii [PDF]
, 2012 A new withanolide, named withawrightolide (1), and four known withanolides (2−5) were isolated from the aerial parts of Datura wrightii. The structure of compound 1 was elucidated through 2D NMR and other spectroscopic techniques.
Joseph Bazzill +17 more
core +1 more source
Induction of Quinone Reductase by Withanolides
Journal of Natural Products, 2002 Thirty-seven naturally occurring withanolides (1-37), previously isolated in our laboratories, were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells (Hepa 1c1c7). Spiranoid (29, 32) and 18-functionalized withanolides (2-5, 7-9, 24) were found to be potent inducers of the enzyme, while 5alpha-substituted ...
Misico, Rosana Isabel +12 more
openaire +3 more sources
Journal of Advanced Pharmaceutical Technology & Research, 2015 Withania somnifera (L.) Dunal, shows several pharmacological properties which are attributed mainly to the withanolides present in the root. The efficacy of medicinally active withanolides constituents depends on the absorption and transportation through
Santosh T Devkar +8 more
doaj +1 more source
Antiproliferative withanolides from several Solanaceous species [PDF]
, 2014 This is an Accepted Manuscript of an article published by Taylor & Francis in Natural Product Research in November 2014, available online: http://www.tandfonline.com/10.1080/14786419.2014.919286.To date, our work on Solanaceous species (Datura wrightii ...
Timmermann, Barbara N. +3 more
core +1 more source