Results 51 to 60 of about 1,755 (175)

Chlorinated withanolides from Withania somnifera [PDF]

Phytochemistry Letters, 2011
A chlorinated withanolide, 6α-chloro-5β,17α-dihydroxywithaferin A (1), and nine known withanolides, 6α-chloro-5β-hydroxywithaferin A (2), (22R)-5β-formyl-6β,27-dihydroxy-1-oxo-4-norwith-24-enolide, withaferin A, 2,3-dihydrowithaferin A, 3-methoxy-2,3-dihydrowithaferin A, 2,3-didehydrosomnifericin, withanone, withanoside IV and withanoside X, were ...
Tong, Xiaoqin, Zhang, Huaping, Timmermann, Barbara N.   +2 more
openaire   +3 more sources

Safety of 8‐Week Administration With Ashwagandha (Withania somnifera) Root Extract in Adults With Stress and Anxiety: Findings From a Prospective, Randomized, Multi‐Center, Double‐Blinded, Placebo‐Controlled Study

Phytotherapy Research, Volume 40, Issue 8, Page 5005-5015, August 2026.
ABSTRACT Ashwagandha ( Withania somnifera ) has been recognized for enhancing physical strength, mental well‐being, and overall vitality. Despite its long‐standing use across generations, some clinical reports have noted occasional adverse events. This study compared the safety and tolerability of Ashwagandha Root Extract (ARE) in healthy adults.
Ketan Pakhale, Jaising Salve, John Ademola, Jose Parraca, Deepak Langade   +4 more
wiley   +1 more source

Laser‐Enabled Biotechnology Platforms for Climate‐Resilient Crop Production: Mechanistic Insights and Future Prospects

Food and Energy Security, Volume 15, Issue 4, July/August 2026.
ABSTRACT Climate change poses a major threat to global food security through extreme weather events, expanding pathogen ranges, and increased agrochemical dependency. This review highlights the emerging role of laser biotechnology as a sustainable and precise strategy to enhance crop resilience and productivity under climate stress.
Temoor Ahmed, Yumeng Lei, Muhammad Noman, Zhitao Li, Gabrijel Ondrasek, Muhammad Shafiq Shahid, Branko Petrinec, Xingjiang Qi, Bin Li, Yetong Qi   +9 more
wiley   +1 more source

Wild type p53 function in p53Y220C mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence

Journal of Experimental & Clinical Cancer Research, 2019
Background Tumor suppressor p53 protein is frequently mutated in a large majority of cancers. These mutations induce local or global changes in protein structure thereby affecting its binding to DNA.
Durai Sundar, Yue Yu, Shashank P. Katiyar, Jayarani F. Putri, Jaspreet Kaur Dhanjal, Jia Wang, Anissa Nofita Sari, Evangelos Kolettas, Sunil C. Kaul, Renu Wadhwa   +9 more
doaj   +1 more source

Molecular dynamics simulations and experimental studies reveal differential permeability of withaferin-A and withanone across the model cell membrane

Scientific Reports, 2021
Poor bioavailability due to the inability to cross the cell membrane is one of the major reasons for the failure of a drug in clinical trials. We have used molecular dynamics simulations to predict the membrane permeability of natural drugs—withanolides (
Renu Wadhwa, Neetu Singh Yadav, Shashank P. Katiyar, Tomoko Yaguchi, Chohee Lee, Hyomin Ahn, Chae-Ok Yun, Sunil C. Kaul, Durai Sundar   +8 more
doaj   +1 more source

Cytotoxic withanolide constituents of Physalis longifolia [PDF]

Planta Medica, 2011
Fourteen new withanolides, 1-14, named withalongolides A-N, respectively, were isolated from the aerial parts of Physalis longifolia together with eight known compounds (15-22). The structures of compounds 1-14 were elucidated through spectroscopic techniques and chemical methods.
Zhang, Huaping, Samadi, Abbas K., Gallagher, Robert J., Araya, Juan Jose, Tong, Xiaoqin, Day, Victor W., Cohen, Mark S., Kindscher, Kelly, Gollapudi, Rao, Timmermann, Barbara N.   +9 more
openaire   +3 more sources

Cytotoxic Withanolides from the Whole Herb of Physalis angulata L.

Molecules, 2019
Physalis angulata L. is a medicinal plant of the Solanaceae family, which is used to produce a variety of steroids. The present study reports on the cytotoxic withanolides of this plant. The species of Physalis angulata L. was identified by DNA barcoding
Qinghong Meng, Jiajia Fan, Zhiguo Liu, Xiwen Li, Fangbo Zhang, Yanlin Zhang, Yi Sun, Li Li, Xia Liu, Erbing Hua   +9 more
doaj   +1 more source

Evaluation of Withaferin A Content in Withania somnifera Using NMR and HPLC: A Comparative Assessment of Traditional and PCSL Extraction Methods

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
A comparative evaluation of traditional aqueous extractions and innovative pressurised cyclic solid–liquid extraction is presented for Withania somnifera leaves. Quantitative NMR, validated by HPLC, reveals a markedly enhanced preservation and recovery of withaferin A using PCSL.
Silvana Pedatella, Maria Chiara Di Meo, Daniele Naviglio, Gionata De Vico, Armando Zarrelli   +4 more
wiley   +1 more source

Deciphering Antidiabetic, Anti‐Inflammatory, and Anti‐Cholinergic Bioactivities of Withania somnifera (L) Dunal Root Extract: An In Vitro and In Silico Investigation

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
In this investigation, Withania somnifera root ethanol extract displays anti‐inflammatory and antidiabetic properties. Though compounds including withasomniferolide B and sitoindoside IX have been previously identified as phytoconstituents in the plant, in silico analysis from this study revealed them as new lead compounds that could act as potential ...
Lufuno Mulelu, Jacqueline N. Manjia, Kolawole A. Olofinsan, Londiwe Xulu, Motlalepula G. Matsabisa   +4 more
wiley   +1 more source

Pharmacological Effects of withanolides [PDF]

Open Access Journal of Complementary & Alternative Medicine, 2019
Withania somnifera (L.) Dunal (Family, Solanaceae) commonly known as Ashwgandha or winter cherry is one of the top medicinal herbs used in Ayurveda-the holistic system of Indian medicine.
openaire   +1 more source