Results 41 to 50 of about 2,412 (209)

Peruranolides A–D, four new withanolides with potential antibacterial and cytotoxic activity from Physalis peruviana L.

Frontiers in Bioscience-Landmark, 2022
Background: Many drugs for anti-tumour have been developed, nevertheless, seeking new anticancer drug is the focus of ongoing investigation. Withanolides have been reported to possess potent antiproliferative activity. Literature findings revealed that a
Qian-Ran Li, Hui-Jun Liang, Bai-Lin Li, Jie Yuan, Zhuo-Yi Ao, Yu-Wen Fan, Wei-Jie Zhang, Xin Lian, Jia-Yan Chen, Jian-Zhong Wang, Jie-Wei Wu   +10 more
doaj   +1 more source

In Vitro Phenotypic Activity and In Silico Analysis of Natural Products from Brazilian Biodiversity on Trypanosoma cruzi

Molecules, 2021
Chagas disease (CD) affects more than 6 million people worldwide. The available treatment is far from ideal, creating a demand for new alternative therapies. Botanical diversity provides a wide range of novel potential therapeutic scaffolds.
Raiza B. Peres, Ludmila F. de A. Fiuza, Patrícia B. da Silva, Marcos M. Batista, Flávia da C. Camillo, André M. Marques, Lavínia de C. Brito, Maria R. Figueiredo, Maria de N. C. Soeiro   +8 more
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Pharmacological Effects of Withanolides [PDF]

Biomedical Journal of Scientific & Technical Research, 2020
Withanolides is a class of active compounds widely found in Solanaceae plants. In traditional applications, it has a long history and a wide range of functions. With the progress of drug structure and pharmacological research, more and more reports point to its excellent anticancer effect.
openaire   +1 more source

Withania somnifera: Advances and Implementation of Molecular and Tissue Culture Techniques to Enhance Its Application

Frontiers in Plant Science, 2017
Withania somnifera, commonly known as Ashwagandha an important medicinal plant largely used in Ayurvedic and indigenous medicine for over 3,000 years. Being a medicinal plant, dried powder, crude extract as well as purified metabolies of the plant has ...
Vibha Pandey, Waquar Akhter Ansari, Pratibha Misra, Neelam Atri   +3 more
doaj   +1 more source

De novo assembly, functional annotation and comparative analysis of Withania somnifera leaf and root transcriptomes to identify putative genes involved in the withanolides biosynthesis. [PDF]

PLoS ONE, 2013
Withania somnifera is one of the most valuable medicinal plants used in Ayurvedic and other indigenous medicine systems due to bioactive molecules known as withanolides.
Parul Gupta, Ridhi Goel, Sumya Pathak, Apeksha Srivastava, Surya Pratap Singh, Rajender Singh Sangwan, Mehar Hasan Asif, Prabodh Kumar Trivedi   +7 more
doaj   +1 more source

Optimization of Elicitation Conditions to Enhance the Production of Potent Metabolite Withanolide from Withania somnifera (L.)

Metabolites, 2022
This study aimed at optimizing conditions for increased withanolide production in Withania somnifera. The elicitors used for the foliar spray on the aerial parts of the plant were salicylic acid, jasmonic acid, and chitosan for the enhancement of ...
Manali Singh, Sanjeev Agrawal, Obaid Afzal, Abdulmalik S. A. Altamimi, Alya Redhwan, Nawaf Alshammari, Mitesh Patel, Mohd Adnan, Abdelbaset Mohamed Elasbali, Shahanavaj Khan   +9 more
doaj   +1 more source

New Spiranoid Withanolides From Jaborosa Odonelliana [PDF]

, 2000
From whole Jaborosa odonelliana plants four new withanolides containing a spiranic lactone in the side chain, were isolated and their structures elucidated by spectroscopic ...
G. Burton, J. C. Oberti, Burton, G., A. S. Veleiro, Cirigliano, A.M., A. M. Cirigliano, Oberti, J.C., Veleiro, A.S.   +7 more
core   +1 more source

Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production

Molecules, 2014
Four new withanolides named dmetelins A–D (compounds 1–4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae).
Bing-You Yang, Rui Guo, Ting Li, Yan Liu, Chang-Fu Wang, Zun-Peng Shu, Zhi-Bin Wang, Jing Zhang, Yong-Gang Xia, Hai Jiang, Qiu-Hong Wang, Hai-Xue Kuang   +11 more
doaj   +1 more source

Physapruin A Induces Reactive Oxygen Species to Trigger Cytoprotective Autophagy of Breast Cancer Cells

Antioxidants, 2022
Physalis peruviana-derived physapruin A (PHA) is a potent compound that selectively generates reactive oxygen species (ROS) and induces cancer cell death. Autophagy, a cellular self-clearance pathway, can be induced by ROS and plays a dual role in cancer
Tzu-Jung Yu, Jun-Ping Shiau, Jen-Yang Tang, Chia-Hung Yen, Ming-Feng Hou, Yuan-Bin Cheng, Chih-Wen Shu, Hsueh-Wei Chang   +7 more
doaj   +1 more source

Two new withanolides from the halophyte Datura stramonium L.

, 2013
Eight steroids, including five withanolides (1-5) and three other ergostane-type steroids (6-8), were isolated from the aerial parts of the halophyte Datura stramonium L., which were collected from the Yellow River Delta in China.
Xia, Chuan-Hai, Xia, CH (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Biol Resources Utilizat, Yantai 264003, Peoples R China. chxia@yic.ac.cn, Kong, Na-Na, Fang, Sheng-Tao, Liu, Su-Jing, Liu, Xia   +5 more
core   +1 more source