Results 61 to 70 of about 2,611 (169)

Burmannic Acid With Normal Cell Safety Exhibits ROS‐Mediated X‐Ray‐Sensitizing Effects on Oral Cancer Cells

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
Burmannic acid (BURA) boosts radiosensitivity in oral cancer: combined with x‐rays, it suppresses tumor growth while sparing normal cells by increasing reactive oxygen species (ROS, MitoSOX), causing G2/M arrest, sub‐G1 accumulation, mitochondrial dysfunction, DNA damage, and apoptosis; these effects are reversed by N‐acetylcysteine. Therefore, BURA is
Kun‐Han Yang, Chung‐Yi Chen, Ching‐Yu Yen, Hsin‐I Lu, Jen‐Yang Tang, Tsu‐Ming Chien, Fang‐Rong Chang, Jiiang‐Huei Jeng, Ming‐Yii Huang, Hsueh‐Wei Chang   +9 more
wiley   +1 more source

In silico evaluation of pharmacokinetics properties of withanolides and simulation of their biological activities against Alzheimer’s disease

, 2023
The withanolides are naturally occurring steroidal lactones found mainly in plants of the Solanaceae family. The subtribe Withaninae includes species like Withania sominifera, which are a source of many bioactive withanolides.
Vinícius G. Maltarollo (15057793), Luana L. Dutra (12083909), Gustavo C. Bressan (4287148), Tiago A. O. Mendes (9177560), Rafael J. Borges (14669276), João Paulo V. Leite (15452435)   +5 more
core   +1 more source

Physapubescin B From Physalis: A Food‐Derived Withanolide for Cancer Chemoprevention and Nutraceutical Development

eFood, Volume 7, Issue 4, August 2026.
Physapubescin B may interfere with multiple cancer‐associated signaling pathways by inhibiting Ras/Raf/mitogen‐activated protein kinase kinase/extracellular signal‐regulated kinase (Ras/Raf/MEK/ERK) signaling and vascular endothelial growth factor (VEGF)‐dependent angiogenesis.
Wojciech Koch, Katarzyna Stępnik, Anna Wawruszak, Estera Okoń, Agata Jarząb, Katarzyna Gaweł‐Bęben, Magdalena Michalak‐Tomczyk, Jacek Jachuła, Magdalena Zdziebło, Paweł Helon, Javad Sharifi‐Rad, Daniela Calina   +11 more
wiley   +1 more source

Effect of the withanolides on ER-positive human breast cancer cells.

, 2013
(A) Withanolides reduce the viability of MCF-7 cells. MCF-7 cells were treated with the indicated concentrations of WA, HW, AA, or PH for 48 h, and cell viability was determined by the MTT assay.
Wen-Ying Chen (320786), Chin-Chung Wu (208863), Fang-Rong Chang (161357), Yi-Ling Tsai (320782), Yang-Chang Wu (4607), Hui-Chun Wang (208862), Mei-Hsin Liu (320785)   +6 more
core   +1 more source

Wild type p53 function in p53Y220C mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence

Journal of Experimental & Clinical Cancer Research, 2019
Background Tumor suppressor p53 protein is frequently mutated in a large majority of cancers. These mutations induce local or global changes in protein structure thereby affecting its binding to DNA.
Durai Sundar, Yue Yu, Shashank P. Katiyar, Jayarani F. Putri, Jaspreet Kaur Dhanjal, Jia Wang, Anissa Nofita Sari, Evangelos Kolettas, Sunil C. Kaul, Renu Wadhwa   +9 more
doaj   +1 more source

Molecular dynamics simulations and experimental studies reveal differential permeability of withaferin-A and withanone across the model cell membrane

Scientific Reports, 2021
Poor bioavailability due to the inability to cross the cell membrane is one of the major reasons for the failure of a drug in clinical trials. We have used molecular dynamics simulations to predict the membrane permeability of natural drugs—withanolides (
Renu Wadhwa, Neetu Singh Yadav, Shashank P. Katiyar, Tomoko Yaguchi, Chohee Lee, Hyomin Ahn, Chae-Ok Yun, Sunil C. Kaul, Durai Sundar   +8 more
doaj   +1 more source

Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1

, 2021
Isocitrate dehydrogenase (IDH) is one key rate-limiting enzyme in the tricarboxylic acid cycle, which is related to various cancers. Tomatillo (Physalis ixocarpa), a special tomato, is widely consumed as nutritious vegetable in Mexico, USA, etc.
Wang, Xuanbin, Li, Hua, Xiang, Ke, Zheng, Mengzhu, Li, Mingxue, Song, Zhuorui, Yang, Yueying, Sun, Dejuan, Chen, Lixia   +8 more
core   +1 more source

Antiproliferative Effects of Withanolides from

, 2009
Extracts of Withania adpressa Coss. (Solanaceae), a medicinal plant endemic to Moroccan Sahara, were tested for their cytotoxicity towards a panel of cancer cell lines (Hep2, HT29, RD, Vero and MDCK), using the (3-[4,5-dimethylthiazol-2-yl]-2,5 ...
Nawal Merghoub, Philippe Christen, Saaïd Amzazi, Kurt Hostettmann, Khalid Bekkouche, Munir Humam, Hamid Morjani, Lalla Hasna Abdeljebbar, Abdelaziz Benjouad, Saoussan El Haddar   +9 more
core   +1 more source

Safety of 12‐Months Administration of Ashwagandha ( Withania somnifera ) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study

Phytotherapy Research, Volume 40, Issue 8, Page 4802-4812, August 2026.
ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve, Sanjeev Kale, Banwari Lal Prajapati, Adele Sparavigna, Mark Savant, John Ademola, Deepak Langade   +6 more
wiley   +1 more source

A Novel Ashwagandha (Withania somnifera) Formulation Mitigates Sleep Deprivation-Induced Cognitive Impairment and Oxidative Stress in a Rat Model

Biomolecules
Ashwagandha (Withania somnifera) is a well-known adaptogenic herb traditionally used to enhance sleep quality and mitigate stress-induced cognitive decline.
Besir Er, Busra Ozmen, Emre Sahin, Cemal Orhan, Nurhan Sahin, Abhijeet A. Morde, Muralidhara Padigaru, Kazim Sahin   +7 more
doaj   +1 more source