Evaluating anticancer properties of Withaferin A—a potent phytochemical
Frontiers in Pharmacology, 2022 Withaferin A is a C28 steroidal lactone derived from the plant Withania somnifera, commonly known as Ashwagandha. Withaferin A has received great attention for its anticancer properties noted in cancer cells of various origins.
Maushma Atteeq
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Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC
Frontiers in Oncology, 2021 Withaferin A, a steroidal lactone derived from the Withania somnifera plant has been known for its anti-cancerous effects on various types of cancer cells.
Divya P Kumar +2 more
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Chitosan activates a sequential Ca 2+ -ROS-NO-jasmonate signaling cascade governing withanolide accumulation in Withania somnifera [PDF]
Plant Signaling & BehaviorChitosan promotes withanolide accumulation in W. somnifera; however, the temporal organization of the underlying signaling network remains unresolved. We examined whether calcium (Ca2⁺), reactive oxygen species (ROS), nitric oxide (NO), and jasmone form ...
Shazia Perveen +8 more
doaj +2 more sources
Formulation and In Vitro Characterisation of Withaferin A-Loaded Liposomal Gels for the Topical Management of Chronic Inflammatory Skin Conditions [PDF]
British Journal of Biomedical ScienceChronic inflammatory skin conditions such as psoriasis, eczema, and acne are driven by sustained inflammation, oxidative stress, and impaired tissue repair.
Mandeep Kaur Marwah +6 more
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Estimation of Withaferin-A by HPLC and standardization of the Ashwagandhadi lehyam formulation
Heliyon, 2021 Standardization is an important measurement for ensuring the quality control of herbal drugs. It has become essential to develop reliable, specific and sensitive quality control methods.
Ajay Kumar Meena, R Ilavarasan
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Cytotoxic Potential Evaluation of Innovative Pressurised Cyclic Solid–Liquid Extracts from Withania somnifera [PDF]
PlantsEthnopharmacological relevance. Withania somnifera (L.) Dunal, widely used in traditional medical systems such as Ayurveda, Unani, and Middle Eastern folk medicine, is valued for its adaptogenic, anti-inflammatory, neuroprotective, antimicrobial, and ...
Rosanna Culurciello +9 more
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Drug Design, Development and Therapy, 2023 Zhichao Xing,1,* Anping Su,1,* Li Mi,1 Yujie Zhang,1 Ting He,1 Yuxuan Qiu,2 Tao Wei,1 Zhihui Li,1 Jingqiang Zhu,1 Wenshuang Wu1 1Division of Thyroid Surgery, Department of General Surgery and Laboratory of Thyroid and Parathyroid Disease ...
Jingqiang Zhu, Anping Su, Wenshuang Wu
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In Silico Identification of Plant-Derived GPX4 Inhibitors as Potential Ferroptosis Inducers: Molecular Docking, Dynamics, and ADMET Studies [PDF]
Current Issues in Molecular BiologyThis study aims identify plant-derived compounds that can inhibit glutathione peroxidase 4 (GPX4) enzyme and evaluate them through molecular docking, dynamics simulations, and ADMET analyses.
Şerife Efsun Antmen +3 more
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Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review. [PDF]
Phytother ResABSTRACT The preclinical evidence for the safety of ashwagandha ( Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports. Most studies and reviews conclude
Williamson EM, Brendler T.
europepmc +2 more sources
Overview of Ayurveda and Ashwagandha: Bioactive Phytochemicals and Potential Applications to Gliomas [PDF]
MoleculesAyurveda is the traditional medical system of India and has been in use for more than 5000 years. The focus of Ayurveda is to maintain harmony and balance of the three Doshas (Vata, Pitta, Kapha), or life forces, that govern the physiology and health of ...
Herbert B. Newton
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