Results 1 to 10 of about 4,082 (209)

Evaluating anticancer properties of Withaferin A—a potent phytochemical

Frontiers in Pharmacology, 2022
Withaferin A is a C28 steroidal lactone derived from the plant Withania somnifera, commonly known as Ashwagandha. Withaferin A has received great attention for its anticancer properties noted in cancer cells of various origins.
Maushma Atteeq
exaly   +5 more sources

Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC

Frontiers in Oncology, 2021
Withaferin A, a steroidal lactone derived from the Withania somnifera plant has been known for its anti-cancerous effects on various types of cancer cells.
Varsha D Shiragannavar, Nirmala G Sannappa Gowda, Divya P Kumar   +2 more
exaly   +3 more sources

Formulation and In Vitro Characterisation of Withaferin A-Loaded Liposomal Gels for the Topical Management of Chronic Inflammatory Skin Conditions [PDF]

British Journal of Biomedical Science
Chronic inflammatory skin conditions such as psoriasis, eczema, and acne are driven by sustained inflammation, oxidative stress, and impaired tissue repair.
Mandeep Kaur Marwah, Hala Shokr, Karan Singh Rana, Yukta Sameer Hindalekar, Rosie Kainth, Parmida Babaei, Shakil Ahmad   +6 more
doaj   +2 more sources

Cytotoxic Potential Evaluation of Innovative Pressurised Cyclic Solid–Liquid Extracts from Withania somnifera [PDF]

Plants
Ethnopharmacological relevance. Withania somnifera (L.) Dunal, widely used in traditional medical systems such as Ayurveda, Unani, and Middle Eastern folk medicine, is valued for its adaptogenic, anti-inflammatory, neuroprotective, antimicrobial, and ...
Rosanna Culurciello, Karen Power, Sergio Esposito, Ilaria Di Nardo, Simone Landi, Gionata De Vico, Domenico Palatucci, Elio Pizzo, Daniele Naviglio, Armando Zarrelli   +9 more
doaj   +2 more sources

Estimation of Withaferin-A by HPLC and standardization of the Ashwagandhadi lehyam formulation

Heliyon, 2021
Standardization is an important measurement for ensuring the quality control of herbal drugs. It has become essential to develop reliable, specific and sensitive quality control methods.
Ajay Kumar Meena, R Ilavarasan
exaly   +3 more sources

Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms

Drug Design, Development and Therapy, 2023
Zhichao Xing,1,* Anping Su,1,* Li Mi,1 Yujie Zhang,1 Ting He,1 Yuxuan Qiu,2 Tao Wei,1 Zhihui Li,1 Jingqiang Zhu,1 Wenshuang Wu1 1Division of Thyroid Surgery, Department of General Surgery and Laboratory of Thyroid and Parathyroid Disease ...
Anping Su, Li Mi, Yuxuan Qiu
exaly   +2 more sources

Deciphering Antidiabetic, Anti-Inflammatory, and Anti-Cholinergic Bioactivities of Withania somnifera (L) Dunal Root Extract: An In Vitro and In Silico Investigation. [PDF]

Chem Biodivers
In this investigation, Withania somnifera root ethanol extract displays anti‐inflammatory and antidiabetic properties. Though compounds including withasomniferolide B and sitoindoside IX have been previously identified as phytoconstituents in the plant, in silico analysis from this study revealed them as new lead compounds that could act as potential ...
Mulelu L, Manjia JN, Olofinsan KA, Xulu L, Matsabisa MG.   +4 more
europepmc   +2 more sources

Overview of Ayurveda and Ashwagandha: Bioactive Phytochemicals and Potential Applications to Gliomas [PDF]

Molecules
Ayurveda is the traditional medical system of India and has been in use for more than 5000 years. The focus of Ayurveda is to maintain harmony and balance of the three Doshas (Vata, Pitta, Kapha), or life forces, that govern the physiology and health of ...
Herbert B. Newton
doaj   +2 more sources

Network pharmacology and in-silico studies for molecular mechanisms of analgesic, anti-inflammatory and anti-arthritic effects of Withania somnifera (L.) Dunal phytoconstituents [PDF]

Journal of Ayurveda and Integrative Medicine
Background: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is an Ayurvedic herb belonging to the family Solanaceae. Objectives: This study aims to explore the analgesic, anti-inflammatory and anti-arthritic potential of phytoconstituents ...
Mukul S. Tambe, Shreyas R. Shinde, Akshay M. Baheti, Shuchi Nagar, Anil T. Pawar   +4 more
doaj   +2 more sources

Computational discovery of natural inhibitors targeting enterovirus D68 3C protease using molecular docking pharmacokinetics and dynamics simulations [PDF]

Scientific Reports
Enterovirus D68 (EV-D68) is a significant global health threat, responsible for severe respiratory and neurological complications, with no FDA-approved antiviral treatments currently available.
Mansoor Alsahag
doaj   +2 more sources