Results 11 to 20 of about 4,082 (209)
Cells, 2022 Background: Retinal ischemia-reperfusion (I/R) injury often results in intractable visual impairments. The survival of retinal capillary endothelial cells is crucial for the treatment of retinal I/R injury.
Zheyi Yan +6 more
doaj +2 more sources
Withaferin A ameliorates ovarian cancer-induced cachexia and proinflammatory signaling
Journal of Ovarian Research, 2019 Background Ovarian cancer is the fifth leading cause of cancer-related deaths amongst women in the United States. Cachexia is the primary cause of death in approximately 30% of cancer patients, and is often evidenced in ovarian cancer patients. We tested
Alex R. Straughn, Sham S. Kakar
doaj +2 more sources
Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition. [PDF]
PLoS ONE, 2013 Though clinicians can predict which patients are at risk for developing metastases, traditional therapies often prove ineffective and metastatic disease is the primary cause of cancer patient death; therefore, there is a need to develop anti-metastatic ...
Zhen Yang +6 more
doaj +3 more sources
Withaferin A inhibits osteosarcoma cells through inactivation of Notch-1 signalling
Bangladesh Journal of Pharmacology, 2014 Human osteosarcoma cells were treated with withaferin A and the antiproliferative activity was evaluated by the 3-(4, 5 dimethyl-thiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assays.
Yang Chen +4 more
doaj +3 more sources
Withaferin A – A natural multifaceted therapeutic compound
Current Botany, 2021 COVID 19, which has lead to the death of millions of people, is still spreading worldwide. The development of any new drug after proper trial is much time consuming. This present global pandemic situation has lead the researchers around the world to run behind various existing antiviral and immunomodulatory natural compounds to overcome this ...
Kalaiselvi Senthil, Sangeetha Vinod
openaire +4 more sources
Obesity: will withaferin win the war?
Nature Medicine, 2016 A new study shows that withaferin A, a steroidal lactone isolated from Withania somnifera, can exert profound metabolic benefits in mice, including body-weight loss, reduced hepatic steatosis and improved glucose control.
Paul T Pfluger, Matthias H Tschöp
openaire +5 more sources
Inhibition of Monosodium Urate Crystal-Induced Inflammation by Withaferin A
Journal of Pharmacy & Pharmaceutical Sciences, 2009 Purpose. Gouty arthritis is a characteristically intense acute inflammatory reaction resulting from the formation of sodium urate crystals in the joint cavity.
Mahaboobkhan Rasool +2 more
doaj +2 more sources
Pharmaceuticals, 2023 Cancer represents the second most deadly disease and one of the most important public health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy are the major types of treatment strategies that have been implemented in cancer
Suneel Kumar +9 more
doaj +3 more sources
Withaferin A Associated Differential Regulation of Inflammatory Cytokines [PDF]
Frontiers in Immunology, 2018 A role of inflammation-associated cytokines/chemokines has been implicated in a wide variety of human diseases. Here, we investigated the regulation of inflammatory cytokines released by monocyte-derived THP-1 cells following treatment with the dietary ...
Seema Dubey +5 more
doaj +3 more sources
Ashwagandha Root Extract and Its Potential Modulation of CCN1‐Associated Pathways in Sensitive‐Skin Aging [PDF]
J Cosmet DermatolABSTRACT Background Cellular Communication Network Factor 1 (CCN1) has been identified as a key regulator of oxidative stress‐induced skin aging and sensitivity. Ashwagandha root extract (ARE) is a promising candidate for modulating CCN1‐associated pathways. Aims To investigate whether ARE can mitigate sensitive‐skin aging by modulating CCN1 expression
Kang L +13 more
europepmc +2 more sources