Results 11 to 20 of about 3,286 (169)
Withaferin A Associated Differential Regulation of Inflammatory Cytokines [PDF]
Frontiers in Immunology, 2018 A role of inflammation-associated cytokines/chemokines has been implicated in a wide variety of human diseases. Here, we investigated the regulation of inflammatory cytokines released by monocyte-derived THP-1 cells following treatment with the dietary ...
Dev Karan +2 more
exaly +5 more sources
Tackling Chronic Inflammation with Withanolide Phytochemicals—A Withaferin A Perspective [PDF]
Antioxidants, 2020 Chronic inflammatory diseases are considered to be one of the biggest threats to human health. Most prescribed pharmaceutical drugs aiming to treat these diseases are characterized by side-effects and negatively affect therapy adherence.
Wim Vanden Berghe +2 more
exaly +6 more sources
Randomized, Double-Blind, Crossover Study Comparing the Bioavailability of 4 Ashwagandha (Withania somnifera (L.) Dunal) Extracts in Healthy Adults Under Fasting Condition [PDF]
Current Therapeutic ResearchBackground: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is a well-known plant in ayurvedic medicine, widely valued for its therapeutic potential. Although numerous clinical studies have explored its diverse health benefits, limited data
Priyank Rathi, MD, Se-Kwon Kim, PhD
doaj +2 more sources
Ashwagandha Root Extract and Its Potential Modulation of CCN1‐Associated Pathways in Sensitive‐Skin Aging [PDF]
J Cosmet DermatolABSTRACT Background Cellular Communication Network Factor 1 (CCN1) has been identified as a key regulator of oxidative stress‐induced skin aging and sensitivity. Ashwagandha root extract (ARE) is a promising candidate for modulating CCN1‐associated pathways. Aims To investigate whether ARE can mitigate sensitive‐skin aging by modulating CCN1 expression
Kang L +13 more
europepmc +2 more sources
Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC
Frontiers in Oncology, 2021 Withaferin A, a steroidal lactone derived from the Withania somnifera plant has been known for its anti-cancerous effects on various types of cancer cells.
Varsha D. Shiragannavar +4 more
doaj +1 more source
Medicine in Drug Discovery, 2022 Withaferin A is a dietary natural compound from a very popular Ayurvedic plant called Ashwagandha (Withania Somnifera). Since the discovery of Withaferin A and its initial isolation and characterization in 1965, a plethora of elegant molecular and ...
Varsha D. Shiragannavar +2 more
doaj +1 more source
Cells, 2022 Background: Retinal ischemia-reperfusion (I/R) injury often results in intractable visual impairments. The survival of retinal capillary endothelial cells is crucial for the treatment of retinal I/R injury.
Zheyi Yan +6 more
doaj +1 more source
Vimentin as a potential therapeutic target in sorafenib resistant HepG2, a HCC model cell line [PDF]
Clinical and Molecular Hepatology, 2020 Background/Aims Hepatocellular carcinoma (HCC) is the most common liver cancer with high mortality rate in patients suffering from liver diseases. The drug of choice used in advanced-stage of HCC is sorafenib.
Ankita Makol +5 more
doaj +1 more source
Withaferin A and Celastrol Overwhelm Proteostasis
International Journal of Molecular Sciences, 2023 Withaferin A (WA) and celastrol (CEL) are major bioactive components of plants that have been widely employed in traditional medicine. The pleiotropic activities of plant preparations and the isolated compounds in vitro and in vivo have been documented in hundreds of studies. Both WA and CEL were shown to have anticancer activity.
Nuria Vilaboa, Richard Voellmy
openaire +4 more sources
Frontiers in Pharmacology, 2023 Introduction: Non-alcoholic fatty liver disease (NAFLD) incidence has been rapidly increasing, and it has emerged as one of the major diseases of the modern world.
Varsha D. Shiragannavar +8 more
doaj +1 more source