Results 21 to 30 of about 3,286 (169)
Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies. [PDF]
PLoS ONE, 2010 BACKGROUND:Vimentin is a ubiquitous mesenchymal intermediate filament supporting mechano-structural integrity of quiescent cells while participating in adhesion, migration, survival, and cell signaling processes via dynamic assembly/disassembly in ...
Guy Lahat +10 more
doaj +1 more source
Structural Elucidation and Antibacterial Activity Studies of Leaf Extracts of Withania somnifera
Indonesian Journal of Chemistry, 2022 Withania somnifera (W. somnifera), a small, woody shrub in the Solanaceae family, has been studied using a phytochemical test, antibacterial activity and partial characterizations. Air-dried and powdered leaves of the plant were extracted with maceration
Amsalu Genanaw Gebeyehu +3 more
doaj +1 more source
Development of withaferin A analogs as probes of angiogenesis [PDF]
Bioorganic & Medicinal Chemistry Letters, 2006 The natural product withaferin A (WFA) is a potent angiogenesis inhibitor and it targets the ubiquitin-proteasome pathway in vascular endothelial cells. We generated a biotinylated affinity analog WFA-LC(2)B for use as a probe to study angiogenesis.
Yasuno, Yokota +4 more
openaire +2 more sources
Scientific Reports, 2021 Poor bioavailability due to the inability to cross the cell membrane is one of the major reasons for the failure of a drug in clinical trials. We have used molecular dynamics simulations to predict the membrane permeability of natural drugs—withanolides (
Renu Wadhwa +8 more
doaj +1 more source
Molecules, 2022 Biphasic calcium phosphate microspheres were synthesized by the water on oil emulsion method and, subsequently, withaferin A was incorporated in the microspheres to evaluate their efficacy in biomedical applications.
Itishree Priyadarshini +3 more
doaj +1 more source
Metabolites, 2022 This study aimed at optimizing conditions for increased withanolide production in Withania somnifera. The elicitors used for the foliar spray on the aerial parts of the plant were salicylic acid, jasmonic acid, and chitosan for the enhancement of ...
Manali Singh +9 more
doaj +1 more source
Withaferin A Improves Nonalcoholic Steatohepatitis in Mice [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2019 Nonalcoholic steatohepatitis (NASH) is the progressive stage of nonalcoholic fatty liver disease that highly increases the risk of cirrhosis and liver cancer, and there are few therapeutic options available in the clinic. Withaferin A (WA), extracted from the ayurvedic medicine Withania somnifera, has a wide range of pharmacological activities; however,
Daxesh P, Patel +6 more
openaire +2 more sources
Pharmaceuticals, 2023 Cancer represents the second most deadly disease and one of the most important public health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy are the major types of treatment strategies that have been implemented in cancer
Suneel Kumar +9 more
doaj +1 more source
Withaferin A ameliorates ovarian cancer-induced cachexia and proinflammatory signaling
Journal of Ovarian Research, 2019 Background Ovarian cancer is the fifth leading cause of cancer-related deaths amongst women in the United States. Cachexia is the primary cause of death in approximately 30% of cancer patients, and is often evidenced in ovarian cancer patients. We tested
Alex R. Straughn, Sham S. Kakar
doaj +1 more source
Withaferin A inhibits osteosarcoma cells through inactivation of Notch-1 signalling
Bangladesh Journal of Pharmacology, 2014 Human osteosarcoma cells were treated with withaferin A and the antiproliferative activity was evaluated by the 3-(4, 5 dimethyl-thiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assays.
Yang Chen +4 more
doaj +1 more source