Results 21 to 30 of about 4,082 (209)
Randomized, Double-Blind, Crossover Study Comparing the Bioavailability of 4 Ashwagandha (Withania somnifera (L.) Dunal) Extracts in Healthy Adults Under Fasting Condition [PDF]
Current Therapeutic ResearchBackground: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is a well-known plant in ayurvedic medicine, widely valued for its therapeutic potential. Although numerous clinical studies have explored its diverse health benefits, limited data
Priyank Rathi, MD, Se-Kwon Kim, PhD
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Tackling Chronic Inflammation with Withanolide Phytochemicals—A Withaferin A Perspective [PDF]
Antioxidants, 2020 Chronic inflammatory diseases are considered to be one of the biggest threats to human health. Most prescribed pharmaceutical drugs aiming to treat these diseases are characterized by side-effects and negatively affect therapy adherence.
Emilie Logie, Wim Vanden Berghe
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Medicine in Drug Discovery, 2022 Withaferin A is a dietary natural compound from a very popular Ayurvedic plant called Ashwagandha (Withania Somnifera). Since the discovery of Withaferin A and its initial isolation and characterization in 1965, a plethora of elegant molecular and ...
Varsha D. Shiragannavar +2 more
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Vimentin as a potential therapeutic target in sorafenib resistant HepG2, a HCC model cell line [PDF]
Clinical and Molecular Hepatology, 2020 Background/Aims Hepatocellular carcinoma (HCC) is the most common liver cancer with high mortality rate in patients suffering from liver diseases. The drug of choice used in advanced-stage of HCC is sorafenib.
Ankita Makol +5 more
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Withaferin A and Celastrol Overwhelm Proteostasis
International Journal of Molecular Sciences, 2023 Withaferin A (WA) and celastrol (CEL) are major bioactive components of plants that have been widely employed in traditional medicine. The pleiotropic activities of plant preparations and the isolated compounds in vitro and in vivo have been documented in hundreds of studies. Both WA and CEL were shown to have anticancer activity.
Nuria Vilaboa, Richard Voellmy
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Frontiers in Pharmacology, 2023 Introduction: Non-alcoholic fatty liver disease (NAFLD) incidence has been rapidly increasing, and it has emerged as one of the major diseases of the modern world.
Varsha D. Shiragannavar +8 more
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Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies. [PDF]
PLoS ONE, 2010 BACKGROUND:Vimentin is a ubiquitous mesenchymal intermediate filament supporting mechano-structural integrity of quiescent cells while participating in adhesion, migration, survival, and cell signaling processes via dynamic assembly/disassembly in ...
Guy Lahat +10 more
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Structural Elucidation and Antibacterial Activity Studies of Leaf Extracts of Withania somnifera
Indonesian Journal of Chemistry, 2022 Withania somnifera (W. somnifera), a small, woody shrub in the Solanaceae family, has been studied using a phytochemical test, antibacterial activity and partial characterizations. Air-dried and powdered leaves of the plant were extracted with maceration
Amsalu Genanaw Gebeyehu +3 more
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Development of withaferin A analogs as probes of angiogenesis [PDF]
Bioorganic & Medicinal Chemistry Letters, 2006 The natural product withaferin A (WFA) is a potent angiogenesis inhibitor and it targets the ubiquitin-proteasome pathway in vascular endothelial cells. We generated a biotinylated affinity analog WFA-LC(2)B for use as a probe to study angiogenesis.
Yasuno, Yokota +4 more
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Withaferin-A compound targeting α-amylase Suppl.files
, 2022 Withaferin-A compound targeting α ...
Aziz Unnisa
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