Results 31 to 40 of about 4,082 (209)

Molecular dynamics simulations and experimental studies reveal differential permeability of withaferin-A and withanone across the model cell membrane

Scientific Reports, 2021
Poor bioavailability due to the inability to cross the cell membrane is one of the major reasons for the failure of a drug in clinical trials. We have used molecular dynamics simulations to predict the membrane permeability of natural drugs—withanolides (
Renu Wadhwa, Neetu Singh Yadav, Shashank P. Katiyar, Tomoko Yaguchi, Chohee Lee, Hyomin Ahn, Chae-Ok Yun, Sunil C. Kaul, Durai Sundar   +8 more
doaj   +1 more source

Electrically Polarized Withaferin A and Alginate-Incorporated Biphasic Calcium Phosphate Microspheres Exhibit Osteogenicity and Antibacterial Activity In Vitro

Molecules, 2022
Biphasic calcium phosphate microspheres were synthesized by the water on oil emulsion method and, subsequently, withaferin A was incorporated in the microspheres to evaluate their efficacy in biomedical applications.
Itishree Priyadarshini, Subhasmita Swain, Janardhan Reddy Koduru, Tapash Ranjan Rautray   +3 more
doaj   +1 more source

Optimization of Elicitation Conditions to Enhance the Production of Potent Metabolite Withanolide from Withania somnifera (L.)

Metabolites, 2022
This study aimed at optimizing conditions for increased withanolide production in Withania somnifera. The elicitors used for the foliar spray on the aerial parts of the plant were salicylic acid, jasmonic acid, and chitosan for the enhancement of ...
Manali Singh, Sanjeev Agrawal, Obaid Afzal, Abdulmalik S. A. Altamimi, Alya Redhwan, Nawaf Alshammari, Mitesh Patel, Mohd Adnan, Abdelbaset Mohamed Elasbali, Shahanavaj Khan   +9 more
doaj   +1 more source

Withaferin A: From Ancient Remedy to Potential Drug Candidate [PDF]

Molecules, 2021
Withaferin A (WA) is a pivotal withanolide that has conquered a conspicuous place in research, owning to its multidimensional biological properties. It is an abundant constituent in Withania somnifera Dunal. (Ashwagandha, WS) that is one of the prehistoric pivotal remedies in Ayurveda.
Tahira Sultana, Mohammad K. Okla, Madiha Ahmed, Nosheen Akhtar, Abdulrahman Al-Hashimi, Hamada Abdelgawad, Ihsan-ul- Haq   +6 more
openaire   +4 more sources

Withaferin A downregulates COX-2/NF-κB signaling and modulates MMP-2/9 in experimental endometriosis

, 2022
Purpose: To study the effect of withaferin A on an experimentally-induced endometriosis (EM) model. Methods: Female Sprague-Dawley rats were induced EM by implantation of autologous endometrium.
Huimin, Wang, Dan, Wang, Xiaoxin, Yang, Yiling, Jiang, Jing, Fan, Chun, Li   +5 more
core   +1 more source

Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives

Biomedicines, 2020
Withaferin A (WA), a manifold studied, C28-steroidal lactone withanolide found in Withania somnifera. Given its unique beneficial effects, it has gathered attention in the era of modern science.
Tapan Behl, Aditi Sharma, Lalit Sharma, Aayush Sehgal, Gokhan Zengin, Roxana Brata, Ovidiu Fratila, Simona Bungau   +7 more
doaj   +1 more source

Withaferin A Improves Nonalcoholic Steatohepatitis in Mice [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2019
Nonalcoholic steatohepatitis (NASH) is the progressive stage of nonalcoholic fatty liver disease that highly increases the risk of cirrhosis and liver cancer, and there are few therapeutic options available in the clinic. Withaferin A (WA), extracted from the ayurvedic medicine Withania somnifera, has a wide range of pharmacological activities; however,
Daxesh P, Patel, Tingting, Yan, Donghwan, Kim, Henrique B, Dias, Kristopher W, Krausz, Shioko, Kimura, Frank J, Gonzalez   +6 more
openaire   +2 more sources

An Adaptogen: Withaferin A Ameliorates in Vitro and in Vivo Pulmonary Fibrosis by Modulating the Interplay of Fibrotic, Matricelluar Proteins, and Cytokines

Frontiers in Pharmacology, 2018
Pulmonary fibrosis (PF) is chronic lung disease with only two FDA approved clinically available drugs, with limited safety profile. Inadequate therapy motivated us to explore the effect of vimentin inhibitor Withaferin A, as an anti-fibrotic agent ...
Swarna Bale, Pooladanda Venkatesh, Manoj Sunkoju, Chandraiah Godugu   +3 more
doaj   +1 more source

Withaferin A for COVID-19: a Network Pharmacology Approach

Applied Biochemistry and Biotechnology, 2023
COVID-19 has become a global challenge as there are very few treatment options available. This has proved to impact several physiological implications like immunological injury, myocardial infarction, micro-thrombus formation, neurological complications and multi-organ dysfunction. A combination therapy or a systems pharmacology approach can be adopted
Ashasmita S. Mishra, Bhuvaneswari Varadarajan, Srayaa Sathish, Sujata Roy   +3 more
openaire   +2 more sources

Withaferin A, a polyfunctional pharmacophore that includes covalent engagement of IPO5, is an inhibitor of influenza A replication

, 2022
Withaferin A, a natural steroidal lactone found in the extracts of Withania somnifera, is used extensively in traditional medicine and part of an ancient remedy in ayurvedic medicine.
Winssinger, Nicolas, Patouret, Rémi, Barluenga Badiola, Sofia   +2 more
core   +1 more source