Results 1 to 10 of about 3,164 (224)

Effect of Withanolide A on 7-Ketocholesterol Induced Cytotoxicity in hCMEC/D3 Brain Endothelial Cells [PDF]

Cells, 2022
Withanolide A is a naturally occurring phytochemical that is found in Ashwagandha (Withania somnifera, fam. Solanaceae) or Indian Ginseng. In the current study, we elucidated the effect of withanolide A on 7-ketocholesterol (7KC) induced injury in hCMEC ...
Sandra Soh, Wei-Yi Ong
doaj   +2 more sources

Optimization of Elicitation Conditions to Enhance the Production of Potent Metabolite Withanolide from Withania somnifera (L.) [PDF]

Metabolites, 2022
This study aimed at optimizing conditions for increased withanolide production in Withania somnifera. The elicitors used for the foliar spray on the aerial parts of the plant were salicylic acid, jasmonic acid, and chitosan for the enhancement of ...
Manali Singh, Sanjeev Agrawal, Obaid Afzal, Abdulmalik S. A. Altamimi, Alya Redhwan, Nawaf Alshammari, Mitesh Patel, Mohd Adnan, Abdelbaset Mohamed Elasbali, Shahanavaj Khan   +9 more
doaj   +2 more sources

Withanolide A prevents neurodegeneration by modulating hippocampal glutathione biosynthesis during hypoxia. [PDF]

PLoS ONE, 2014
Withania somnifera root extract has been used traditionally in ayurvedic system of medicine as a memory enhancer. Present study explores the ameliorative effect of withanolide A, a major component of withania root extract and its molecular mechanism ...
Iswar Baitharu, Vishal Jain, Satya Narayan Deep, Sabita Shroff, Jayanta Kumar Sahu, Pradeep Kumar Naik, Govindasamy Ilavazhagan   +6 more
doaj   +3 more sources

Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis [PDF]

Nature Communications
Withanolides are steroidal lactones from nightshade (Solanaceae) plants with untapped drug potential due to limited availability of minor representatives caused by lack of biosynthetic pathway knowledge.
Samuel Edward Hakim, Nancy Choudhary, Karan Malhotra, Jian Peng, Arne Bültemeier, Ahmed Arafa, Ronja Friedhoff, Maximilian Bauer, Jessica Eikenberg, Claus-Peter Witte, Marco Herde, Philipp Heretsch, Boas Pucker, Jakob Franke   +13 more
doaj   +2 more sources

Randomized, Double-Blind, Crossover Study Comparing the Bioavailability of 4 Ashwagandha (Withania somnifera (L.) Dunal) Extracts in Healthy Adults Under Fasting Condition [PDF]

Current Therapeutic Research
Background: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is a well-known plant in ayurvedic medicine, widely valued for its therapeutic potential. Although numerous clinical studies have explored its diverse health benefits, limited data
Priyank Rathi, MD, Se-Kwon Kim, PhD
doaj   +2 more sources

Network pharmacology and in-silico studies for molecular mechanisms of analgesic, anti-inflammatory and anti-arthritic effects of Withania somnifera (L.) Dunal phytoconstituents [PDF]

Journal of Ayurveda and Integrative Medicine
Background: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is an Ayurvedic herb belonging to the family Solanaceae. Objectives: This study aims to explore the analgesic, anti-inflammatory and anti-arthritic potential of phytoconstituents ...
Mukul S. Tambe, Shreyas R. Shinde, Akshay M. Baheti, Shuchi Nagar, Anil T. Pawar   +4 more
doaj   +2 more sources

Cytotoxic Potential Evaluation of Innovative Pressurised Cyclic Solid–Liquid Extracts from Withania somnifera [PDF]

Plants
Ethnopharmacological relevance. Withania somnifera (L.) Dunal, widely used in traditional medical systems such as Ayurveda, Unani, and Middle Eastern folk medicine, is valued for its adaptogenic, anti-inflammatory, neuroprotective, antimicrobial, and ...
Rosanna Culurciello, Karen Power, Sergio Esposito, Ilaria Di Nardo, Simone Landi, Gionata De Vico, Domenico Palatucci, Elio Pizzo, Daniele Naviglio, Armando Zarrelli   +9 more
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Metabolism of Epoxidised Withanolides by a Generalist and a Specialist Insect Species [PDF]

ChemistryOpen
Major secondary metabolites of Physalis plants, epoxidized withanolides, have a potent feeding deterrent and growth inhibitory effect on most herbivorous insects.
Marie Pauline Sell, Christian Paetz, Felix Feistel, David G. Heckel, Yannick Pauchet   +4 more
doaj   +2 more sources

Molecular characterization of three CYP450 genes reveals their role in withanolides formation and defense in Withania somnifera, the Indian Ginseng

Scientific Reports, 2022
The medicinal properties of Ashwagandha (Withania somnifera) are attributed to triterpenoid steroidal lactones, withanolides, which are proposed to be derived from phytosterol pathway, through the action of cytochrome P450 (CYP450) enzymes.
H. B. Shilpashree, S. J. Sudharshan, Ajit K. Shasany, Dinesh A. Nagegowda   +3 more
doaj   +1 more source

Pharmacokinetics and bioequivalence of Withania somnifera (Ashwagandha) extracts – A double blind, crossover study in healthy adults

Heliyon, 2023
Introduction: Withania somnifera (WS) or ashwagandha is an adaptogenic plant used extensively in traditional medicines and as a food supplement. Despite a long history of use and numerous clinical trials, the human pharmacokinetics of withanolides, the ...
Se-Kwon Kim, Jayachandran Venkatesan, Priyank Rathi, Benny Antony   +3 more
doaj   +1 more source