Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis [PDF]
Nature CommunicationsWithanolides are steroidal lactones from nightshade (Solanaceae) plants with untapped drug potential due to limited availability of minor representatives caused by lack of biosynthetic pathway knowledge.
Samuel Edward Hakim +13 more
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Cells, 2022 Withanolide A is a naturally occurring phytochemical that is found in Ashwagandha (Withania somnifera, fam. Solanaceae) or Indian Ginseng. In the current study, we elucidated the effect of withanolide A on 7-ketocholesterol (7KC) induced injury in hCMEC ...
Sandra Soh, Wei-Yi Ong
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Frontiers in Plant Science, 2023 IntroductionHumanity is suffering from huge and severe difficulties, including changes in climate, soil degradation, scarcity of water and the security of food and medicines, among others.
Manali Singh +8 more
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International Journal of Nanomedicine, 2020 Qudsia Tabassam,1 Tahir Mehmood,1,2 Abdul Rauf Raza,1 Azmat Ullah,3 Farhan Saeed,4 Faqir Muhammad Anjum5 1Department of Chemistry, University of Sargodha, Sargodha, Pakistan; 2Institute of Biochemistry and Biotechnology, University of Veterinary and ...
Tabassam Q +5 more
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Withanolide A prevents neurodegeneration by modulating hippocampal glutathione biosynthesis during hypoxia. [PDF]
PLoS ONE, 2014 Withania somnifera root extract has been used traditionally in ayurvedic system of medicine as a memory enhancer. Present study explores the ameliorative effect of withanolide A, a major component of withania root extract and its molecular mechanism ...
Iswar Baitharu +6 more
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Randomized, Double-Blind, Crossover Study Comparing the Bioavailability of 4 Ashwagandha (Withania somnifera (L.) Dunal) Extracts in Healthy Adults Under Fasting Condition [PDF]
Current Therapeutic ResearchBackground: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is a well-known plant in ayurvedic medicine, widely valued for its therapeutic potential. Although numerous clinical studies have explored its diverse health benefits, limited data
Priyank Rathi, MD, Se-Kwon Kim, PhD
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Network pharmacology and in-silico studies for molecular mechanisms of analgesic, anti-inflammatory and anti-arthritic effects of Withania somnifera (L.) Dunal phytoconstituents [PDF]
Journal of Ayurveda and Integrative MedicineBackground: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is an Ayurvedic herb belonging to the family Solanaceae. Objectives: This study aims to explore the analgesic, anti-inflammatory and anti-arthritic potential of phytoconstituents ...
Mukul S. Tambe +4 more
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Cytotoxic Potential Evaluation of Innovative Pressurised Cyclic Solid–Liquid Extracts from Withania somnifera [PDF]
PlantsEthnopharmacological relevance. Withania somnifera (L.) Dunal, widely used in traditional medical systems such as Ayurveda, Unani, and Middle Eastern folk medicine, is valued for its adaptogenic, anti-inflammatory, neuroprotective, antimicrobial, and ...
Rosanna Culurciello +9 more
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Metabolism of Epoxidised Withanolides by a Generalist and a Specialist Insect Species [PDF]
ChemistryOpenMajor secondary metabolites of Physalis plants, epoxidized withanolides, have a potent feeding deterrent and growth inhibitory effect on most herbivorous insects.
Marie Pauline Sell +4 more
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PlantsWithanolides are naturally occurring steroidal lactones found in certain species of the Withania genus, especially Withania somnifera (commonly known as Ashwagandha).
Zishan Ahmad +6 more
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