Results 11 to 20 of about 3,164 (224)

Enhancing Withanolide Production in the Withania Species: Advances in In Vitro Culture and Synthetic Biology Approaches [PDF]

Plants
Withanolides are naturally occurring steroidal lactones found in certain species of the Withania genus, especially Withania somnifera (commonly known as Ashwagandha).
Zishan Ahmad, Shareen, Irfan Bashir Ganie, Fatima Firdaus, Muthusamy Ramakrishnan, Anwar Shahzad, Yulong Ding   +6 more
doaj   +2 more sources

Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer [PDF]

Drug Design, Development and Therapy, 2017
Dharmendra K Yadav,1 Surendra Kumar,2 Saloni,1 Harpreet Singh,3 Mi-hyun Kim,1 Praveen Sharma,4 Sanjeev Misra,4 Feroz Khan5 1Department of Pharmacy, College of Pharmacy, Gachon University, Yeonsu-gu, Incheon, Republic of Korea; 2Faculty of Pharmacy ...
Yadav DK, Kumar S, Saloni, Singh H, Kim M, Sharma P, Misra S, Khan F   +7 more
doaj   +1 more source

Anxiolytic and Memory Protective Effects of Withanolide D Isolated From Acnistus arborescens in Adult Zebrafish. [PDF]

Chem Biodivers
Withanolide D Exhibits Anxiolytic and Memory‐Protective Effects. ABSTRACT This study evaluated the anxiolytic and memory‐protective effects of withanolide D in adult zebrafish (Danio rerio). The compound was administered at doses of 4, 20, and 40 mg/kg and showed no signs of toxicity after 96 h of observation at any of the doses tested.
de Sousa Feitosa CR, Alves Da Silva J, Maciel JB, Romão IC, Cavalcante TR, Barros FAN, de Abreu Bandeira N, Marinho ES, Menezes JESA, Ferreira MKA, Wlisses Da Silva A, Marinho MM, Rocha MND, Pessoa ODL, Batista PHJ, De Castro Gomes AF, Teixeira AMR, Dos Santos HS.   +17 more
europepmc   +2 more sources

Deciphering Antidiabetic, Anti-Inflammatory, and Anti-Cholinergic Bioactivities of Withania somnifera (L) Dunal Root Extract: An In Vitro and In Silico Investigation. [PDF]

Chem Biodivers
In this investigation, Withania somnifera root ethanol extract displays anti‐inflammatory and antidiabetic properties. Though compounds including withasomniferolide B and sitoindoside IX have been previously identified as phytoconstituents in the plant, in silico analysis from this study revealed them as new lead compounds that could act as potential ...
Mulelu L, Manjia JN, Olofinsan KA, Xulu L, Matsabisa MG.   +4 more
europepmc   +2 more sources

Withanolide-Type Steroids from Physalis nicandroides Inhibit HIV Transcription [PDF]

, 2021
The aim of the present study is to report the isolation, structural elucidation, and antiviral evaluation of four new withanolide-type steroids, named nicansteroidins A–D (1–4), together with nine related known compounds (5–13) isolated from the aerial ...
Manuela Beltrán (1673608), Vito A. Taddeo (11466755), Luis M. Bedoya (1673611), Ulises G. Castillo (11466758), Marvin J. Núñez (3225402), Ignacio A. Jiménez (1673614), Isabel L. Bazzocchi (1421170), José Alcamí (1618549), Jenny Menjívar (11466761)   +8 more
core   +1 more source

An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha)

Frontiers in Pharmacology, 2023
Withania somnifera (L.) Dunal belongs to the nightshade family Solanaceae and is commonly known as Ashwagandha. It is pharmacologically a significant medicinal plant of the Indian sub-continent, used in Ayurvedic and indigenous systems of medicine for ...
Arsalan Bashir, Masarat Nabi, Nahida Tabassum, Suhaib Afzal, Mehrose Ayoub   +4 more
doaj   +1 more source

Benefits of Withania somnifera (Ashwagandha) supplementation in obesity

Journal of Education, Health and Sport, 2023
Introduction and purpose: Ashwagandha (fam. Solanaceae) also known as Withania somnifera, is an herb commonly used in traditional Ayurvedic medicine. It is sometimes called Indian ginseng or winter cherry and it is used for its extensive health benefits
Alicja Nowak, Klaudia Bogusz, Natalia Baran, Marcela Maksymowicz, Adriana Bielak, Aleksandra Nowak, Łucja Cywka, Weronika Szwed, Piotr Machowiec   +8 more
doaj   +1 more source

Study of Drug Target Identification and Associated Molecular Mechanisms for the Therapeutic Activity and Hair Follicle Induction of Two Ashwagandha Extracts Having Differential Withanolide Constitutions

Journal of Nutrition and Metabolism, 2023
Background. Ashwagandha extracts play a significant role in traditional Indian medicine to help treat a wide range of disorders from amnesia, erectile dysfunction, neurodegenerative and cardiovascular diseases, cancer, stress, anxiety, and many more ...
Franco Cavaleri, Sukalpa Chattopadhyay, Vrushalee Palsule, Pradip Kumar Kar, Ritam Chatterjee   +4 more
doaj   +1 more source

Estimating the production of withaferin A and withanolide A in Withania somnifera (L.) dunal using aquaponics for sustainable development in hill agriculture

Frontiers in Plant Science, 2023
IntroductionHumanity is suffering from huge and severe difficulties, including changes in climate, soil degradation, scarcity of water and the security of food and medicines, among others.
Manali Singh, Shivani Bhutani, Nisha Dinkar, Anita Mishra, Kahkashan Perveen, Alanoud T. Alfagham, Mehrun Nisha Khanam, Santosh Chandra Bhatt, Deep Chandra Suyal   +8 more
doaj   +1 more source

Withanolides and Related Steroids [PDF]

, 2011
Since the isolation of the first withanolides in the mid-1960s, over 600 new members of this group of compounds have been described, with most from genera of the plant family Solanaceae. The basic structure of withaferin A, a C28 ergostane with a modified side chain forming a δ-lactone between carbons 22 and 26, was considered for many years the basic ...
Misico, Rosana Isabel, Nicotra, Viviana Estela, Oberti, Juan Carlos María, Barboza, Gloria Estela, Gil, Roberto Ricardo, Burton, Gerardo   +5 more
openaire   +3 more sources