Results 21 to 30 of about 114,627,962 (212)
Withanolide-Type Steroids from Physalis nicandroides Inhibit HIV Transcription
, 2021 The aim of the present study is to report the isolation, structural elucidation, and antiviral evaluation of four new withanolide-type steroids, named nicansteroidins A–D (1–4), together with nine related known compounds (5–13) isolated from the aerial ...
Manuela Beltrán (1673608) +8 more
core +1 more source
Withanolides and Related Steroids [PDF]
, 2011 Since the isolation of the first withanolides in the mid-1960s, over 600 new members of this group of compounds have been described, with most from genera of the plant family Solanaceae. The basic structure of withaferin A, a C28 ergostane with a modified side chain forming a δ-lactone between carbons 22 and 26, was considered for many years the basic ...
Misico, Rosana Isabel +5 more
openaire +3 more sources
The Total Synthesis of Analogues of Withanolide F [PDF]
, 2014 The total synthesis of analogues of withanolide F I, a highly oxygenated C-28 steroidal lactone natural product isolated from the leaves of the plant Withania adpressa is discussed herein. Chapter 1 describes the classification of the withanolides, their
Manicassamy, Laura
core +6 more sources
Withanolide A: synthesis and structural requirements for neurite outgrowth [PDF]
, 2013 The exploration of different routes leading to the stereoselective synthesis of the neuritogenic steroid withanolide A is reported in full detail. Notable features of the synthesis include a Corey–Seebach homologation, a vinylogous aldol reaction, a ...
Jessen, Henning J. +12 more
core +1 more source
Integrative Medicine Research, 2013 Background: Ashwagandharishtha is a liquid polyherbal formulation traditionally prepared by fermentation process using the flowers of Woodfordia fruticosa. It contains roots of Withania somnifera as a major crude drug.
Jagdish Manwar +4 more
doaj +1 more source
Biologia Plantarum, 2011 Squalene synthase (SS) dimerizes two molecules of farnesyl diphosphate to synthesize squalene, a shared precursor in steroid and triterpenoid biosynthesis in plants.
M. H. Mirjalili +4 more
doaj +1 more source
ANN Based Virtual Classification Model for Discriminating Active and Inactive Withanolide E Analogs against Human Breast Cancer Cell Line MCF-7 [PDF]
, 2011 Withanolides are a group of natural C-28 steroids built on an ergostane skeleton and classified into two major groups according to their structural skeleton: (a) compounds with a beta-oriented side chain and (b) compounds with an alpha-oriented side ...
Feroz Khan, Om Prakash, R.S. Sangwan
core +1 more source
Withanolide-Type Steroids from Physalis nicandroides Inhibit HIV Transcription
, 2021 The aim of the present study is to report the isolation, structural elucidation, and antiviral evaluation of four new withanolide-type steroids, named nicansteroidins A-D (1-4), together with nine related known compounds (5-13) isolated from the aerial ...
Alcamí, José +8 more
core +1 more source
RNAi and Homologous Over-Expression Based Functional Approaches Reveal Triterpenoid Synthase Gene-Cycloartenol Synthase Is Involved in Downstream Withanolide Biosynthesis in Withania somnifera. [PDF]
PLoS ONE, 2016 Withania somnifera Dunal, is one of the most commonly used medicinal plant in Ayurvedic and indigenous medicine traditionally owing to its therapeutic potential, because of major chemical constituents, withanolides.
Smrati Mishra +6 more
doaj +1 more source
Induction of Quinone Reductase by Withanolides
Journal of Natural Products, 2002 Thirty-seven naturally occurring withanolides (1-37), previously isolated in our laboratories, were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells (Hepa 1c1c7). Spiranoid (29, 32) and 18-functionalized withanolides (2-5, 7-9, 24) were found to be potent inducers of the enzyme, while 5alpha-substituted ...
Misico, Rosana Isabel +12 more
openaire +3 more sources