Withanolide A: synthesis and structural requirements for neurite outgrowth [PDF]
, 2013 The exploration of different routes leading to the stereoselective synthesis of the neuritogenic steroid withanolide A is reported in full detail. Notable features of the synthesis include a Corey–Seebach homologation, a vinylogous aldol reaction, a ...
Jessen, Henning J. +12 more
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Integrative Medicine Research, 2013 Background: Ashwagandharishtha is a liquid polyherbal formulation traditionally prepared by fermentation process using the flowers of Woodfordia fruticosa. It contains roots of Withania somnifera as a major crude drug.
Jagdish Manwar +4 more
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Molecular dynamics simulations reveal the inhibitory mechanism of Withanolide A against α-glucosidase and α-amylase [PDF]
, 2023 Diabetes mellitus (DM) is a global chronic disease characterized by hyperglycemia and insulin resistance. The unsavory severe gastrointestinal side-effects of synthetic drugs to regulate hyperglycemia have warranted the search for alternative treatments ...
Mohd Hayrie, Mohd Hatta +5 more
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ANN Based Virtual Classification Model for Discriminating Active and Inactive Withanolide E Analogs against Human Breast Cancer Cell Line MCF-7 [PDF]
, 2011 Withanolides are a group of natural C-28 steroids built on an ergostane skeleton and classified into two major groups according to their structural skeleton: (a) compounds with a beta-oriented side chain and (b) compounds with an alpha-oriented side ...
Feroz Khan, Om Prakash, R.S. Sangwan
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Biologia Plantarum, 2011 Squalene synthase (SS) dimerizes two molecules of farnesyl diphosphate to synthesize squalene, a shared precursor in steroid and triterpenoid biosynthesis in plants.
M. H. Mirjalili +4 more
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RNAi and Homologous Over-Expression Based Functional Approaches Reveal Triterpenoid Synthase Gene-Cycloartenol Synthase Is Involved in Downstream Withanolide Biosynthesis in Withania somnifera. [PDF]
PLoS ONE, 2016 Withania somnifera Dunal, is one of the most commonly used medicinal plant in Ayurvedic and indigenous medicine traditionally owing to its therapeutic potential, because of major chemical constituents, withanolides.
Smrati Mishra +6 more
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Chemical structure of Withanolide A. [PDF]
, 2014 Chemical structure of Withanolide A.
Thangavel Samikkannu (471645) +5 more
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Elucidating the active interaction mechanism of phytochemicals withanolide and withanoside derivatives with human serum albumin. [PDF]
PLoS ONE, 2018 Withania somnifera (Ashwagandha) is an efficient medicinal plant known in Ayurveda and Chinese medicine since ancient times, whose extracts are consumed orally as food supplement or as a health tonic owing to its several restorative properties for ...
Shreya Dubey +3 more
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Pubescenol, a withanolide from Physalis pubescence [PDF]
, 1984 A new withanolide, named pubescenol, and also physalin E and physalin E acetate have been isolated from Physalis pubescence. The structure of pubescenol is assigned as 4α,7α-dihydroxy-l-oxo-24α,25α-epoxy-2,3 ...
Dhaveji, K. +3 more
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A new withanolide from the roots of Withania somnifera [PDF]
, 2004 2001-2003Phytochemical studies on the roots of Withania somnifera (Solanaceae) resulted in the isolation of a new withanolide glycoside, glucosomniferanolide, characterized as (20R, 22S)- 1-oxo-witha-2, 5, 24-trienolide-20-β-ol-20-D-glucopyranoside by
M. Ali +5 more
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