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Frontiers in Plant Science, 2022 Ashwagandha (Withania somnifera L. Dunal) is a medicinally important plant with withanolides as its major bioactive compounds, abundant in the roots and leaves.
Sachin Ashok Thorat +9 more
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Withanolide A mediated transcriptional regulation of Nrf2 and GCLC expression depend on corticosterone signaling in hippocampus. [PDF]
, 2014 Withanolide A administration during hypoxic exposure upregulates Nrf2 and GCLC expression in hippocampus. Administration of Withanolide A alongwith exogenous corticosterone supplementation to the normoxic group decrease the Nrf2 as well as GCLC ...
Pradeep Kumar Naik (436805) +6 more
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Modulation of hippocampal endogenous glutathione level by Withanolide A reduces hypoxia induced neurodegeneration. [PDF]
, 2014 Withanolide A effectively decreases the number of degenerating neurons caused by hypoxic exposure. However, depletion of glutathione using buthionine sulfoximine during hypoxic exposure increases the number degenerating cells in hippocampus.
Pradeep Kumar Naik (436805) +6 more
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Pharmacological Effects of Withanolides [PDF]
Biomedical Journal of Scientific & Technical Research, 2020 Withanolides is a class of active compounds widely found in Solanaceae plants. In traditional applications, it has a long history and a wide range of functions. With the progress of drug structure and pharmacological research, more and more reports point to its excellent anticancer effect.
openaire +1 more source
Modulatory effects of Withanolide A and β-Amyloid1-42 on human neuronal cells. [PDF]
, 2014 A. Dose-response of Withanolide A showing growth-stimulatory effects in terms of % viability. B. MTT assay showing the inhibition of cell viability by β-Amyloid1-42 and its reversal by Withanolide A at two concentrations on SK-N-MC cells. The values were
Thangavel Samikkannu (471645) +5 more
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مجلة مركز بحوث التقنيات الاحيائيةBackground: Withania somnifera L. is a famous medicinal plant that has been utilized in Global folk medicine for a long time. The leaves and roots of the plant are rich in withanolide constituents, which are primarily responsible for their therapeutic ...
Ashwaq S. Abed +2 more
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Molecules, 2023 Cancer is characterized by the abnormal development of cells that divide in an uncontrolled manner and further take over the body and destroy the normal cells of the body.
Sanjay H. Deshpande +9 more
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Pubescenol, a new withanolide from Physalis pubescence [PDF]
, 1985 The isolation from Physalis pubescence of a new withanolide (now named pubescenol) and physalin E and its acetate is reported. The structure of pubescenol was shown to be 2,3-dihydro-4α ,7α -dihydroxy-1-oxo-24α ,25α -epoxywithanolide on the basis of its ...
Sambi Reddy, K. +2 more
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Effect of heavy metals on germination, biochemical, antioxidant and withanolide content in Withania somnifera (L.) Dunal [PDF]
, 2023 Withania somnifera (L.) Dunal., commonly referred to as Ashwagandha, is a medicinal plant from the solanaceae family with a wide range of pharmacological properties. W.
Akshatha Banadka +3 more
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NADPH-cytochrome P450 reductase: molecular cloning and functional characterization of two paralogs from Withania somnifera (L.) dunal. [PDF]
PLoS ONE, 2013 Withania somnifera (L.) Dunal, a highly reputed medicinal plant, synthesizes a large array of steroidal lactone triterpenoids called withanolides. Although its chemical profile and pharmacological activities have been studied extensively during the last ...
Satiander Rana +6 more
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