Results 61 to 70 of about 3,164 (224)

A Novel Withanolide Glucoside from the Rhizomes of Dioscorea panthaica [PDF]

, 2013
A novel withanolide type C-28-steroid saponin, named dioscolide glucoside, was isolated from the rhizomes of Dioscorea panthaica Prain et Buckill. The structure was elucidated as (20S,22R,24R,25S)-1-oxo-2 alpha,3 alpha;6 alpha,7 alpha-diepoxy-5 alpha,16 ...
Wang Xiaoling, Liang Jian, Shan Xiaoqing, Ding Lisheng, Peng Shulin   +4 more
core  

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan, Candace L. Doepker, Gregory P. Brorby   +2 more
wiley   +1 more source

A decade of molecular understanding of withanolide biosynthesis and in vitro studies in Withania somnifera (L.) Dunal: Prospects and perspectives for pathway engineering

Frontiers in Plant Science, 2015
Withania somnifera, a multipurpose medicinal plant is a rich reservoir of pharmaceutically active triterpenoids that are steroidal lactones known as withanolides.
Niha eDhar, Sumeer eRazdan, Satiander eRana, Wajid Waheed Bhat, Ram eVishwakarma, Surrinder K. Lattoo   +5 more
doaj   +1 more source

Chlorinated withanolides from Withania somnifera [PDF]

Phytochemistry Letters, 2011
A chlorinated withanolide, 6α-chloro-5β,17α-dihydroxywithaferin A (1), and nine known withanolides, 6α-chloro-5β-hydroxywithaferin A (2), (22R)-5β-formyl-6β,27-dihydroxy-1-oxo-4-norwith-24-enolide, withaferin A, 2,3-dihydrowithaferin A, 3-methoxy-2,3-dihydrowithaferin A, 2,3-didehydrosomnifericin, withanone, withanoside IV and withanoside X, were ...
Tong, Xiaoqin, Zhang, Huaping, Timmermann, Barbara N.   +2 more
openaire   +3 more sources

Effect of Withanolide A on oxidative stress markers. [PDF]

, 2014
Administration of Withanolide A decreases the hypoxia induced elevated level of reactive oxygen species, lipid peroxidation and GSH in hippocampus. Data expressed as percentage change taking normoxic value as 100% and represents Mean ± SEM. ‘a’ denotes p≤
Pradeep Kumar Naik (436805), Jayanta Kumar Sahu (643672), Vishal Jain (14349), Govindasamy Ilavazhagan (414361), Iswar Baitharu (414359), Satya Narayan Deep (643670), Sabita Shroff (643671)   +6 more
core   +1 more source

Safety of 8‐Week Administration With Ashwagandha (Withania somnifera) Root Extract in Adults With Stress and Anxiety: Findings From a Prospective, Randomized, Multi‐Center, Double‐Blinded, Placebo‐Controlled Study

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha (Withania somnifera) has been recognized for enhancing physical strength, mental well‐being, and overall vitality. Despite its long‐standing use across generations, some clinical reports have noted occasional adverse events. This study compared the safety and tolerability of Ashwagandha Root Extract (ARE) in healthy adults.
Ketan Pakhale, Jaising Salve, John Ademola, Jose Parraca, Deepak Langade   +4 more
wiley   +1 more source

Data for: Profiling Withanolide A for Therapeutic Targets in Neurodegenerative Diseases [PDF]

, 2019
This is the supporting information for the article by Crane et al, (2019) "Profiling Withanolide A for Therapeutic Targets in Neurodegenerative Diseases "
Gademann, K
core   +3 more sources

WsCAS transcript expression analysis and withanolide accumulation in Withania silencing and overexpressing lines. [PDF]

, 2016
(A) RealTime PCR analysis of WsCAS silenced lines. (B) Withanolide content in silenced lines. (C) Real-Time PCR analysis of WsCAS overexpressing lines. (D) Withanolide content in WsCAS overexpressing lines.
Asha (2504188), Jyoti Singh Jadaun (2504191), Smrati Mishra (2504185), Shilpi Bansal (2504179), Neelam S. Sangwan (534505), Bhawana Mishra (2504182), Rajender Singh Sangwan (411130)   +6 more
core   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source