Results 61 to 70 of about 114,627,962 (212)

Chlorinated withanolides from Withania somnifera [PDF]

Phytochemistry Letters, 2011
A chlorinated withanolide, 6α-chloro-5β,17α-dihydroxywithaferin A (1), and nine known withanolides, 6α-chloro-5β-hydroxywithaferin A (2), (22R)-5β-formyl-6β,27-dihydroxy-1-oxo-4-norwith-24-enolide, withaferin A, 2,3-dihydrowithaferin A, 3-methoxy-2,3-dihydrowithaferin A, 2,3-didehydrosomnifericin, withanone, withanoside IV and withanoside X, were ...
Tong, Xiaoqin, Zhang, Huaping, Timmermann, Barbara N.   +2 more
openaire   +3 more sources

A Withanolide-rich Fraction of Athenaea velutina Induces Apoptosis and Cell Cycle Arrest in Melanoma B16F10 Cells

, 2021
Athenaea velutina is a promising Brazilian shrub with cytotoxic and antimigratory properties against cancer cells. However, the mechanism of induction of cancer cell death and the compounds involved remain unknown. To ascertain these bioactive compounds,
Lima, Graziela D. A., Leite, João P. V., Rodrigues, Laís A., De Oliveira, Leandro L., Almeida, Alisson A., A. Do Vale, Juliana, Bressan, Gustavo C., Eiterer, Marinês, Zanatta, Ana C. [UNESP]   +8 more
core   +1 more source

Screening of phytochemicals from Withania somnifera, Rauwolfia serpentina, Curcuma longa, and Camellia sinensis for potential maltase-glucoamylase (MGAM) inhibition using molecular docking, molecular dynamics simulation, and ADMET analysis

In Silico Research in Biomedicine
Postprandial hyperglycemia is a major concern in type 2 diabetes, and inhibition of intestinal α-glucosidases [maltase-glucoamylase (MGAM)] is an established approach for controlling postprandial glucose excursions.
Ashim Chandra Roy, Ilora Ghosh
doaj   +1 more source

A decade of molecular understanding of withanolide biosynthesis and in vitro studies in Withania somnifera (L.) Dunal: Prospects and perspectives for pathway engineering

Frontiers in Plant Science, 2015
Withania somnifera, a multipurpose medicinal plant is a rich reservoir of pharmaceutically active triterpenoids that are steroidal lactones known as withanolides.
Niha eDhar, Sumeer eRazdan, Satiander eRana, Wajid Waheed Bhat, Ram eVishwakarma, Surrinder K. Lattoo   +5 more
doaj   +1 more source

Burmannic Acid With Normal Cell Safety Exhibits ROS‐Mediated X‐Ray‐Sensitizing Effects on Oral Cancer Cells

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
Burmannic acid (BURA) boosts radiosensitivity in oral cancer: combined with x‐rays, it suppresses tumor growth while sparing normal cells by increasing reactive oxygen species (ROS, MitoSOX), causing G2/M arrest, sub‐G1 accumulation, mitochondrial dysfunction, DNA damage, and apoptosis; these effects are reversed by N‐acetylcysteine. Therefore, BURA is
Kun‐Han Yang, Chung‐Yi Chen, Ching‐Yu Yen, Hsin‐I Lu, Jen‐Yang Tang, Tsu‐Ming Chien, Fang‐Rong Chang, Jiiang‐Huei Jeng, Ming‐Yii Huang, Hsueh‐Wei Chang   +9 more
wiley   +1 more source

Chemical structures of the withanolide compounds.

, 2013
Chemical structures of the withanolide compounds.
Wen-Ying Chen (320786), Chin-Chung Wu (208863), Fang-Rong Chang (161357), Yi-Ling Tsai (320782), Yang-Chang Wu (4607), Hui-Chun Wang (208862), Mei-Hsin Liu (320785)   +6 more
core   +1 more source

Physapubescin B From Physalis: A Food‐Derived Withanolide for Cancer Chemoprevention and Nutraceutical Development

eFood, Volume 7, Issue 4, August 2026.
Physapubescin B may interfere with multiple cancer‐associated signaling pathways by inhibiting Ras/Raf/mitogen‐activated protein kinase kinase/extracellular signal‐regulated kinase (Ras/Raf/MEK/ERK) signaling and vascular endothelial growth factor (VEGF)‐dependent angiogenesis.
Wojciech Koch, Katarzyna Stępnik, Anna Wawruszak, Estera Okoń, Agata Jarząb, Katarzyna Gaweł‐Bęben, Magdalena Michalak‐Tomczyk, Jacek Jachuła, Magdalena Zdziebło, Paweł Helon, Javad Sharifi‐Rad, Daniela Calina   +11 more
wiley   +1 more source

A New Rearranged Non-Aromatic Salpichrolide from Salpichroa Origanifolia

Molecules, 2000
From the aerial parts of Salpichroa origanifolia a new withanolide in which the C-13 angular methyl has migrated to C-17, was isolated and characterized by spectroscopic methods.
M. C. Tettamanzi, J. R. De La Fuente, A. S. Veleiro, G. Burton   +3 more
doaj   +1 more source

Sonication, Vacuum Infiltration and Thiol Compounds Enhance the Agrobacterium-Mediated Transformation Frequency of Withania somnifera (L.) Dunal. [PDF]

PLoS ONE, 2015
In the present study, we have established a stable transformation protocol via Agrobacterium tumafacines for the pharmaceutically important Withania somnifera.
Ganeshan Sivanandhan, Gnajothi Kapil Dev, Jeevaraj Theboral, Natesan Selvaraj, Andy Ganapathi, Markandan Manickavasagam   +5 more
doaj   +1 more source

Antitumor Potential of Withanolide Glycosides from Ashwagandha (Withania somnifera) on Apoptosis of Human Hepatocellular Carcinoma Cells and Tube Formation in Human Umbilical Vein Endothelial Cells

Antioxidants, 2022
Hepatocellular carcinoma (HCC) is the fastest-growing tumor capable of spreading to other organs via blood vessels formed by endothelial cells. Apoptosis and angiogenesis-targeting therapies are attractive for cancer treatment. In this study, we aimed to
Dahae Lee, Jae Sik Yu, Ji Won Ha, Seoung Rak Lee, Bum Soo Lee, Jin-Chul Kim, Jung Kyu Kim, Ki Sung Kang, Ki Hyun Kim   +8 more
doaj   +1 more source