Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. [PDF]
PLoS ONE, 2014 The present study investigated the biosynthesis of major and minor withanolides of Withania somnifera in cell suspension culture using shake-flask culture and bioreactor by exploiting elicitation and precursor feeding strategies.
Ganeshan Sivanandhan +3 more
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International Journal of Nanomedicine, 2020 Qudsia Tabassam,1 Tahir Mehmood,1,2 Abdul Rauf Raza,1 Azmat Ullah,3 Farhan Saeed,4 Faqir Muhammad Anjum5 1Department of Chemistry, University of Sargodha, Sargodha, Pakistan; 2Institute of Biochemistry and Biotechnology, University of Veterinary and ...
Tabassam Q +5 more
doaj
Environment Conservation Journal, 2013 Withania somnifera L. Dunal (Ashwagandha) also known as Indian ginseng, of the family Solanaceae is an important ancient medicinal plant, used in the Indian traditional system of medicine. The medicinal importance of W.
Neelima Ratti, Avinash Upadhyay
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Long-Lasting WNT-TCF Response Blocking and Epigenetic Modifying Activities of Withanolide F in Human Cancer Cells. [PDF]
PLoS ONE, 2016 The WNT-TCF signaling pathway participates in adult tissue homeostasis and repair, and is hyperactive in a number of human diseases including cancers of the colon. Whereas to date there are no antagonists approved for patient use, a potential problem for
Chandan Seth +7 more
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Engineering of Saccharomyces cerevisiae for 24-Methylene-Cholesterol Production
Biomolecules, 2021 24-Methylene-cholesterol is a necessary substrate for the biosynthesis of physalin and withanolide, which show promising anticancer activities. It is difficult and costly to prepare 24-methylene-cholesterol via total chemical synthesis. In this study, we
Jiao Yang, Changfu Li, Yansheng Zhang
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Elucidating the active interaction mechanism of phytochemicals withanolide and withanoside derivatives with human serum albumin - Fig 7 [PDF]
, 2018 Molecular docking studies between HSA and withanolide A, withanolide B, withanoside IV and withanoside V showed that the minimum binding energy conformer is very close to the experimentally determined values.
Arijit Sarkar (5942156) +3 more
core +1 more source
Transmission Electron Microscopic (TEM) studies to visualize alteration in HSA molecule topology in presence of withanolide and withanoside derivatives at 200 nM resolution. [PDF]
, 2018 (A) Only HSA (B) HSA+withanolide A, (C) HSA+withanolide B, (D) HSA+withanolide IV and (E) HSA+withanolide V.
Arijit Sarkar (5942156) +3 more
core +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve +6 more
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Talasteroid, a new withanolide from the marine-derived fungus Talaromyces stollii [PDF]
, 2022 A new withanolide, talasteroid (1), and a known steroid (2), along with eight meroterpenoids (3–10), were obtained from the rice culture of the marine-derived fungus Talaromyces stollii HBU-115. The structure of 1 including its absolute configuration was
Hui-Fang Du (12469260) +5 more
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Ashwagandha: Is It Safe? Part 1: A Regulatory Review
Phytotherapy Research, EarlyView.ABSTRACT Over the last decade, ashwagandha (Withania somnifera (L.) Dunal, AS) has been brought under increasing scrutiny by EU regulators regarding its safety for the use in food supplements, culminating in a recent recommendation for an Article 8 procedure according to Regulation (EC) No. 1925/2006 in the European Union (EU).
T. Brendler +5 more
wiley +1 more source