A Withanolide-rich Fraction of Athenaea velutina Induces Apoptosis and Cell Cycle Arrest in Melanoma B16F10 Cells [PDF]
, 2021 Athenaea velutina is a promising Brazilian shrub with cytotoxic and antimigratory properties against cancer cells. However, the mechanism of induction of cancer cell death and the compounds involved remain unknown. To ascertain these bioactive compounds,
Lima, Graziela D. A. +8 more
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Environment Conservation Journal, 2010 Ashwagandha [Withania somnifera (L.) Dunal] is an important medicinal plant and its medicinal properties have been attributed to various classes of withanolide compounds.
H. Punetha, Shiv Om Singh, A. K. Gaur
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Cells, 2022 Oxidative stress and the AKT serine/threonine kinase (AKT) signaling pathway are essential regulators in cellular migration, metastasis, and angiogenesis.
Jen-Yang Tang +6 more
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Induction of Quinone Reductase by Withanolides
Journal of Natural Products, 2002 Thirty-seven naturally occurring withanolides (1-37), previously isolated in our laboratories, were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells (Hepa 1c1c7). Spiranoid (29, 32) and 18-functionalized withanolides (2-5, 7-9, 24) were found to be potent inducers of the enzyme, while 5alpha-substituted ...
Misico, Rosana Isabel +12 more
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Withanolide A mediated restoration of endogenous glutathione level reverses hypoxia induced neuronal apoptosis in hippocampus. [PDF]
, 2014 Administration of withanolide A prior to and during hypoxic exposure decreases number of apoptotic cells in CA3 region of hippocampus while glutathione depletion using buthionine sulfoximine elevates hypoxic neuronal apoptosis.
Pradeep Kumar Naik (436805) +6 more
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Withanolides from Withania coagulans
Phytochemistry, 2003 Two withanolides, 20beta-hydroxy-1-oxo-(22R)-witha-2,5,24-trienolide (1) and withacoagulin (2), along with a known withanolide, 17beta-hydroxy-14alpha, 20alpha-epoxy-1-oxo-(22R)-witha-3,5,24-trienolide (3) were isolated from Withania coagulans. Their structures were elucidated with the help of different spectroscopic techniques.
Atta, ur-Rahman +3 more
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De novo assembly, functional annotation and comparative analysis of Withania somnifera leaf and root transcriptomes to identify putative genes involved in the withanolides biosynthesis. [PDF]
PLoS ONE, 2013 Withania somnifera is one of the most valuable medicinal plants used in Ayurvedic and other indigenous medicine systems due to bioactive molecules known as withanolides.
Parul Gupta +7 more
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Orizabolide, a New Withanolide from Physalis orizabae [PDF]
, 2017 A new withanolide, orizabolide (<strong>1</strong>), together with the known flavonoid rutin (<strong>2</strong>) were isolated from the aerial parts of <em>Physalis orizabae</em>.
Mahinda Martínez +3 more
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Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine
Molecules, 2009 Withania somnifera, commonly known as Ashwagandha, is an important medicinal plant that has been used in Ayurvedic and indigenous medicine for over 3,000 years.
Javier Palazón +4 more
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Withanolide A mediated elevation of hippocampal glutathione during hypoxia is corticosterone dependent. [PDF]
, 2014 Withanolide A administration during hypoxic exposure upregulates Nrf2 and GCLC expression in hippocampus. Administration of Withanolide A alongwith exogenous corticosterone supplementation to the normoxic group decrease the Nrf2 as well as GCLC ...
Pradeep Kumar Naik (436805) +6 more
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