Results 31 to 40 of about 23,202,835 (216)

Differential Gene Expression and Withanolides Biosynthesis During in vitro and ex vitro Growth of Withania somnifera (L.) Dunal

Frontiers in Plant Science, 2022
Ashwagandha (Withania somnifera L. Dunal) is a medicinally important plant with withanolides as its major bioactive compounds, abundant in the roots and leaves.
Sachin Ashok Thorat, Arya Kaniyassery, Poornima Poojari, Melissa Rangel, Shashikala Tantry, Kodsara Ramachandra Kiran, Manjunath B. Joshi, Padmalatha S. Rai, Anna-Maria Botha, Annamalai Muthusamy   +9 more
doaj   +1 more source

Profiling withanolide A for therapeutic targets in neurodegenerative diseases.

Bioorganic & Medicinal Chemistry, 2019
To identify new potential therapeutic targets for neurodegenerative diseases, we initiated activity-based protein profiling studies with withanolide A (WitA), a known neuritogenic constituent of Withania somnifera root with unknown mechanism of action ...
E. A. Crane, Wolfgang Heydenreuter, Katharina R. Beck, Petra Strajhar, Jan Vomacka, M. Smieško, Elma Mons, L. Barth, M. Neuburger, A. Vedani, A. Odermatt, S. Sieber, K. Gademann   +12 more
semanticscholar   +1 more source

Pharmacological Effects of Withanolides [PDF]

Biomedical Journal of Scientific & Technical Research, 2020
Withanolides is a class of active compounds widely found in Solanaceae plants. In traditional applications, it has a long history and a wide range of functions. With the progress of drug structure and pharmacological research, more and more reports point to its excellent anticancer effect.
openaire   +1 more source

Using silver nanoparticles to increase the accumulation of withanolide compounds in cultured callus of Withania somnifera L.

مجلة مركز بحوث التقنيات الاحيائية
Background: Withania somnifera L. is a famous medicinal plant that has been utilized in Global folk medicine for a long time. The leaves and roots of the plant are rich in withanolide constituents, which are primarily responsible for their therapeutic ...
Ashwaq S. Abed, Alaa J. Taha , Abedaljasim M. J. Al Jibouri   +2 more
doaj   +1 more source

In Silico Study on the Interactions, Molecular Docking, Dynamics and Simulation of Potential Compounds from Withania somnifera (L.) Dunal Root against Cancer by Targeting KAT6A

Molecules, 2023
Cancer is characterized by the abnormal development of cells that divide in an uncontrolled manner and further take over the body and destroy the normal cells of the body.
Sanjay H. Deshpande, Abdullatif Bin Muhsinah, Zabin K. Bagewadi, Gireesh M. Ankad, Mater H. Mahnashi, Deepak A. Yaraguppi, Ibrahim Ahmed Shaikh, Aejaz Abdullatif Khan, Harsha V. Hegde, Subarna Roy   +9 more
doaj   +1 more source

NADPH-cytochrome P450 reductase: molecular cloning and functional characterization of two paralogs from Withania somnifera (L.) dunal. [PDF]

PLoS ONE, 2013
Withania somnifera (L.) Dunal, a highly reputed medicinal plant, synthesizes a large array of steroidal lactone triterpenoids called withanolides. Although its chemical profile and pharmacological activities have been studied extensively during the last ...
Satiander Rana, Surrinder K Lattoo, Niha Dhar, Sumeer Razdan, Wajid Waheed Bhat, Rekha S Dhar, Ram Vishwakarma   +6 more
doaj   +1 more source

Ashwagandha (Withania somnifera (L.) Dunal) root extract containing withanolide A alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic factor pathway under unexpected chronic mild stress.

Journal of Ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE Ashwagandha (Withania somnifera (L.) Dunal) root or whole-plant extracts are used to treat anxiety, insomnia, and other nervous system disturbances.
Hyeongyeong Kim, Hyeon-Son Choi, K. Han, Wansup Sim, Hyung Joo Suh, Yejin Ahn   +5 more
semanticscholar   +1 more source

Long-Lasting WNT-TCF Response Blocking and Epigenetic Modifying Activities of Withanolide F in Human Cancer Cells. [PDF]

PLoS ONE, 2016
The WNT-TCF signaling pathway participates in adult tissue homeostasis and repair, and is hyperactive in a number of human diseases including cancers of the colon. Whereas to date there are no antagonists approved for patient use, a potential problem for
Chandan Seth, Christophe Mas, Arwen Conod, Jens Mueller, Karsten Siems, Monika Kuciak, Isabel Borges, Ariel Ruiz I Altaba   +7 more
doaj   +1 more source

Influence of Glomus intraradices on growth, biochemical changes and withanolides content of Withania somnifera L Dunal (Ashwagandha)

Environment Conservation Journal, 2013
Withania somnifera L. Dunal (Ashwagandha) also known as Indian ginseng, of the family Solanaceae is an important ancient medicinal plant, used in the Indian traditional system of medicine. The medicinal importance of W.
Neelima Ratti, Avinash Upadhyay
doaj   +1 more source

Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. [PDF]

PLoS ONE, 2014
The present study investigated the biosynthesis of major and minor withanolides of Withania somnifera in cell suspension culture using shake-flask culture and bioreactor by exploiting elicitation and precursor feeding strategies.
Ganeshan Sivanandhan, Natesan Selvaraj, Andy Ganapathi, Markandan Manickavasagam   +3 more
doaj   +1 more source