Results 71 to 80 of about 114,627,962 (212)
, 2014 Withanolide A administration during hypoxic exposure upregulates Nrf2 and GCLC expression in hippocampus. Administration of Withanolide A alongwith exogenous corticosterone supplementation to the normoxic group decrease the Nrf2 as well as GCLC ...
Pradeep Kumar Naik (436805) +6 more
core +1 more source
Toxicology Reports, 2014 The present study investigated the possible protective role of Withania somnifera (Linn.) Dunal (Solanaceae) root powder against bromobenzene-induced oxidative damage in rat liver mitochondria.
Mahima Vedi +2 more
doaj +1 more source
Phytotherapy Research, Volume 40, Issue 8, Page 4802-4812, August 2026.ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve +6 more
wiley +1 more source
, 2014 Withanolide A administration during hypoxic exposure upregulates Nrf2 and GCLC expression in hippocampus. Administration of Withanolide A alongwith exogenous corticosterone supplementation to the normoxic group decrease the Nrf2 as well as GCLC ...
Pradeep Kumar Naik (436805) +6 more
core +1 more source
Tackling Chronic Inflammation with Withanolide Phytochemicals—A Withaferin A Perspective
Antioxidants, 2020 Chronic inflammatory diseases are considered to be one of the biggest threats to human health. Most prescribed pharmaceutical drugs aiming to treat these diseases are characterized by side-effects and negatively affect therapy adherence.
Emilie Logie, Wim Vanden Berghe
doaj +1 more source
Ashwagandha: Is It Safe? Part 1: A Regulatory Review
Phytotherapy Research, Volume 40, Issue 8, Page 4845-4857, August 2026.ABSTRACT Over the last decade, ashwagandha ( Withania somnifera (L.) Dunal, AS) has been brought under increasing scrutiny by EU regulators regarding its safety for the use in food supplements, culminating in a recent recommendation for an Article 8 procedure according to Regulation (EC) No. 1925/2006 in the European Union (EU).
T. Brendler +5 more
wiley +1 more source
, 2014 Withanolide A effectively decreases the number of degenerating neurons caused by hypoxic exposure. However, depletion of glutathione using buthionine sulfoximine during hypoxic exposure increases the number degenerating cells in hippocampus.
Pradeep Kumar Naik (436805) +6 more
core +1 more source
Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)
Phytotherapy Research, Volume 40, Issue 8, Page 4880-4897, August 2026.ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley +1 more source
Modulatory effects of Withanolide A and β-Amyloid1-42 on human neuronal cells.
, 2014 A. Dose-response of Withanolide A showing growth-stimulatory effects in terms of % viability. B. MTT assay showing the inhibition of cell viability by β-Amyloid1-42 and its reversal by Withanolide A at two concentrations on SK-N-MC cells. The values were
Thangavel Samikkannu (471645) +5 more
core +1 more source
Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha ( Withania somnifera )
Phytotherapy Research, Volume 40, Issue 8, Page 5030-5047, August 2026.Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan +2 more
wiley +1 more source