Results 71 to 80 of about 23,202,835 (216)

Withametelin: a biologically active withanolide in cancer, inflammation, pain and depression

Saudi Pharmaceutical Journal, 2020
Withanolides are natural medicinal agents whose safety and therapeutic profiles make them valuable to mankind. Among multiple withanolides, withametelin is underexplored.
Muhammad Waleed Baig, Bakht Nasir, Durdana Waseem, Muhammad Majid, Muhammad Zafar Irshad Khan, Ihsan-ul Haq   +5 more
doaj   +1 more source

Withanolide A: synthesis and structural requirements for neurite outgrowth

, 2013
The exploration of different routes leading to the stereoselective synthesis of the neuritogenic steroid withanolide A is reported in full detail. Notable features of the synthesis include a Corey–Seebach homologation, a vinylogous aldol reaction, a ...
Raphael Liffert, Johannes Hoecker, C. Jana, T. M. Woods, P. Burch, H. Jessen, M. Neuburger, K. Gademann   +7 more
semanticscholar   +1 more source

Simultaneous Determination of Withanolide A and Bacoside A in Spansules by High-Performance Thin-Layer Chromatography

Indian Journal of Pharmaceutical Sciences, 2011
The objective of this work was to develop and validate a simple, rapid, precise, and accurate high performance thin layer chromatography method for simultaneous determination of withanolide A and bacoside A in combined dosage form.
Fulzele Sv, Joshi Sb
semanticscholar   +1 more source

Structure-based virtual screening methods for the identification of novel phytochemical inhibitors targeting furin protease for the management of COVID-19

Frontiers in Cellular and Infection Microbiology
The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, is a highly contagious respiratory disease with widespread societal impact.
Prashant Kumar Tiwari, Mandeep Chouhan, Richa Mishra, Saurabh Gupta, Anis Ahmad Chaudhary, Mohammed Al-Zharani, Ashraf Ahmed Qurtam, Fahd A. Nasr, Niraj Kumar Jha, Niraj Kumar Jha, Niraj Kumar Jha, Kumud Pant, Mukesh Kumar, Sanjay Kumar   +13 more
doaj   +1 more source

Synergistic activity of nootropic herbs as potent therapeutics for Alzheimer's disease: A cheminformatics, pharmacokinetics, and system pharmacology approach

Journal of Alzheimer's Disease Reports
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which subdues over 55 million people and finding a cure, still remains disenchanting.
Reiya Bosco Don Bosco, Johnson Retnaraj Samuel Selvan Christyraj, Beryl Vedha Yesudhason   +2 more
doaj   +1 more source

Molecular Modeling, NOESY NMR, and the Structure of Nicandrenone Isolated from (Solanaceae)

Natural Product Communications, 2009
The configuration and conformation of nicandrenone, isolated from Nicandra physalodes , are described using molecular modeling and NMR NOESY techniques.
Patrick F. Jonas, Geoffrey A. Cordell
doaj   +1 more source

Evaluation of the bioavailability of major withanolides of Withania somnifera using an in vitro absorption model system

Journal of Advanced Pharmaceutical Technology & Research, 2015
Withania somnifera (L.) Dunal, shows several pharmacological properties which are attributed mainly to the withanolides present in the root. The efficacy of medicinally active withanolides constituents depends on the absorption and transportation through
Santosh T Devkar, Amit D Kandhare, Brian D Sloley, Suresh D Jagtap, James Lin, Yun K Tam, Surendra S Katyare, Subhash L Bodhankar, Mahabaleshwar V Hegde   +8 more
doaj   +1 more source

Withanolide A and Asiatic Acid Modulate Multiple Targets Associated with Amyloid-β Precursor Protein Processing and Amyloid-β Protein Clearance

Journal of Natural Products, 2010
Alzheimer’s disease (AD) is a progressive, neurodegenerative disease histochemically characterized by extracellular deposits of amyloid beta (Aβ) protein and intracellular neurofibrillary tangles of hyperphosphorylated tau protein. AD is considered to be
S. Patil, Sara Maki, Santosh A. Khedkar, A. C. Rigby, C. Chan   +4 more
semanticscholar   +1 more source

Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer

Drug Design, Development and Therapy, 2017
Dharmendra K Yadav,1 Surendra Kumar,2 Saloni,1 Harpreet Singh,3 Mi-hyun Kim,1 Praveen Sharma,4 Sanjeev Misra,4 Feroz Khan5 1Department of Pharmacy, College of Pharmacy, Gachon University, Yeonsu-gu, Incheon, Republic of Korea; 2Faculty of Pharmacy ...
Yadav DK, Kumar S, Saloni, Singh H, Kim M, Sharma P, Misra S, Khan F   +7 more
doaj  

Bioactive metabolites from the leaves of Withania adpressa

Pharmaceutical Biology, 2018
Context: Withania (Solanaceae) species are known to be a rich source of withanolides, which have shown several biological properties. Objective: To identify the compounds responsible for Withania adpressa Coss.
Widad Ben Bakrim, Laila El Bouzidi, Jean-Marc Nuzillard, Sylvian Cretton, Noémie Saraux, Aymeric Monteillier, Philippe Christen, Muriel Cuendet, Khalid Bekkouche   +8 more
doaj   +1 more source