Results 91 to 100 of about 114,627,962 (212)

Transmission Electron Microscopic (TEM) studies to visualize alteration in HSA molecule topology in presence of withanolide and withanoside derivatives at 200 nM resolution.

, 2018
(A) Only HSA (B) HSA+withanolide A, (C) HSA+withanolide B, (D) HSA+withanolide IV and (E) HSA+withanolide V.
Arijit Sarkar (5942156), Monika Kallubai (618436), Shreya Dubey (3820303), Rajagopal Subramanyam (297691)   +3 more
core   +1 more source

Structure-based virtual screening methods for the identification of novel phytochemical inhibitors targeting furin protease for the management of COVID-19

Frontiers in Cellular and Infection Microbiology
The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, is a highly contagious respiratory disease with widespread societal impact.
Prashant Kumar Tiwari, Mandeep Chouhan, Richa Mishra, Saurabh Gupta, Anis Ahmad Chaudhary, Mohammed Al-Zharani, Ashraf Ahmed Qurtam, Fahd A. Nasr, Niraj Kumar Jha, Niraj Kumar Jha, Niraj Kumar Jha, Kumud Pant, Mukesh Kumar, Sanjay Kumar   +13 more
doaj   +1 more source

WsCAS transcript expression analysis and withanolide accumulation in Withania silencing and overexpressing lines.

, 2016
(A) RealTime PCR analysis of WsCAS silenced lines. (B) Withanolide content in silenced lines. (C) Real-Time PCR analysis of WsCAS overexpressing lines. (D) Withanolide content in WsCAS overexpressing lines.
Asha (2504188), Jyoti Singh Jadaun (2504191), Smrati Mishra (2504185), Shilpi Bansal (2504179), Neelam S. Sangwan (534505), Bhawana Mishra (2504182), Rajender Singh Sangwan (411130)   +6 more
core   +1 more source

Synergistic activity of nootropic herbs as potent therapeutics for Alzheimer's disease: A cheminformatics, pharmacokinetics, and system pharmacology approach

Journal of Alzheimer's Disease Reports
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which subdues over 55 million people and finding a cure, still remains disenchanting.
Reiya Bosco Don Bosco, Johnson Retnaraj Samuel Selvan Christyraj, Beryl Vedha Yesudhason   +2 more
doaj   +1 more source

Molecular Modeling, NOESY NMR, and the Structure of Nicandrenone Isolated from (Solanaceae)

Natural Product Communications, 2009
The configuration and conformation of nicandrenone, isolated from Nicandra physalodes , are described using molecular modeling and NMR NOESY techniques.
Patrick F. Jonas, Geoffrey A. Cordell
doaj   +1 more source

Evaluation of the bioavailability of major withanolides of Withania somnifera using an in vitro absorption model system

Journal of Advanced Pharmaceutical Technology & Research, 2015
Withania somnifera (L.) Dunal, shows several pharmacological properties which are attributed mainly to the withanolides present in the root. The efficacy of medicinally active withanolides constituents depends on the absorption and transportation through
Santosh T Devkar, Amit D Kandhare, Brian D Sloley, Suresh D Jagtap, James Lin, Yun K Tam, Surendra S Katyare, Subhash L Bodhankar, Mahabaleshwar V Hegde   +8 more
doaj   +1 more source

Antitumor effect of withanolide D: a scoping review protocol

This scoping review aims to identify studies that have investigated the antitumor effects of withanolide D and map the main ...
Karuza Maria Aves Pereira, Sthefane Gomes Feitosa, Denis Francisco Gonçalves de Oliveira   +2 more
core   +1 more source

Bioactive metabolites from the leaves of Withania adpressa

Pharmaceutical Biology, 2018
Context: Withania (Solanaceae) species are known to be a rich source of withanolides, which have shown several biological properties. Objective: To identify the compounds responsible for Withania adpressa Coss.
Widad Ben Bakrim, Laila El Bouzidi, Jean-Marc Nuzillard, Sylvian Cretton, Noémie Saraux, Aymeric Monteillier, Philippe Christen, Muriel Cuendet, Khalid Bekkouche   +8 more
doaj   +1 more source

Atomic Force Microscopic (AFM) studies to visualize alteration in HSA molecule topology in presence of withanolide and withanoside derivatives at 10 μM resolution.

, 2018
(A) Only HSA (B) HSA+withanolide A (C) HSA+withanolide B (D) HSA+withanolide IV and (E) HSA+withanolide V.
Arijit Sarkar (5942156), Monika Kallubai (618436), Shreya Dubey (3820303), Rajagopal Subramanyam (297691)   +3 more
core   +1 more source

Integrative Machine Learning, Virtual Screening, and Molecular Modeling for BacA-Targeted Anti-Biofilm Drug Discovery Against Staphylococcal Infections

Crystals
The rise in antibiotic-resistant Staphylococcal infections necessitates innovative approaches to identify new therapeutic agents. This study investigates the application of machine learning models to identify potential phytochemical inhibitors against ...
Ahmad Almatroudi
doaj   +1 more source