Results 81 to 90 of about 23,202,835 (216)

Integrative Machine Learning, Virtual Screening, and Molecular Modeling for BacA-Targeted Anti-Biofilm Drug Discovery Against Staphylococcal Infections

Crystals
The rise in antibiotic-resistant Staphylococcal infections necessitates innovative approaches to identify new therapeutic agents. This study investigates the application of machine learning models to identify potential phytochemical inhibitors against ...
Ahmad Almatroudi
doaj   +1 more source

Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L.

Beilstein Journal of Organic Chemistry, 2019
Withanolides are steroidal lactones widespread in Nightshade plants with often potent antiproliferative activities. Additionally, the structural diversity of this compound class holds much potential for the discovery of novel biological activity.
Annika Stein, Dave Compera, Bianka Karge, Mark Brönstrup, Jakob Franke   +4 more
doaj   +1 more source

Shoden promotes Relief from stress and anxiety: A randomized, double-blind, placebo-controlled study on healthy subjects with high stress levels

Heliyon
Background: This randomized placebo-controlled study examined the effect of ashwagandha root and leaf extract 60 mg (AE60) and 120 mg (AE120) (35 % withanolide glycosides, Shoden) in physically healthy subjects with higher stress and anxiety.
Deo Nidhi Mishra, Manoj Kumar
doaj   +1 more source

Withanolide glycosides from Physalis volubilis

Fitoterapia
The study of the acetone and methanol extracts of the stems, leaves, and flowers of Physalis volubilis led to obtain four withanolide glycosides (4, 6, 10, and 14). Compounds 1-3, 13, 15, and a sterol glycoside were also isolated. The structures were established by analysis of spectroscopic and spectrometric data, and by chemical transformations.
Ana-L, Pérez-Castorena, Tonantzin G, Anguheven L, M Azucena, Martínez R, Jesús, Morales-Jiménez, Emma, Maldonado, Mahinda, Martínez   +5 more
openaire   +2 more sources

Finding potential inhibitors from phytochemicals against nucleoprotein of crimean congo fever virus using in silico approach

Scientific Reports
The Crimean Congo virus has been reported to be a part of the spherical RNA-enveloped viruses from the Bunyaviridae family. Crimean Congo fever (CCHF) is a fatal disease with having fatality rate of up to 40%.
Muhammad Ramzan, Sajid Mahmood, Adnan Amjad, Mohsin Javed, Ammar Zidan, Ali Bahadur, Shahid Iqbal, Muhammad Saad, Namrah Zaka, Shazia Khurshid, Nasser S. Awwad, Hala A. Ibrahium, Toheed Akhter   +12 more
doaj   +1 more source

Withanolides of Datura stramonium [PDF]

Chemistry of Natural Compounds, 1976
R. N. Tursunova, V. A. Maslennikova, N. K. Abubakirov   +2 more
openaire   +1 more source

Nutraceutical Applications of <i>Withania somnifera</i>: The Scientific Knowledge for Rational Modern Use of the "Ayurvedic Adaptogen". [PDF]

Foods
Pandey S, Pant P, Corbioli G, Bonazzi E, Cisneros-Yupanqui M, Salmaso P, Dall'Acqua S.   +6 more
europepmc   +1 more source

Withanolides Are Detected in Human Urine Following Oral Administration of a <i>Withania somnifera</i> Product. [PDF]

Int J Mol Sci
Speers AB, Limoico ED, Lozano-Ortiz A, Marney L, Choi J, Barr SA, Williamson RT, Strangman WK, Maier CS, Soumyanath A.   +9 more
europepmc   +1 more source

Computational evaluation of <i>Withania somnifera</i> phytocompounds targeting SARS-CoV-2 ORF9b Protein: Insights from molecular docking, ADMET and MD simulations. [PDF]

Curr Res Struct Biol
Patel MS, Singh M, Solanki MB.
europepmc   +1 more source

Molecular docking analysis of DprE1 from <i>M. tuberculosis</i> with phytochemicals. [PDF]

Bioinformation
Raja J, Blessy JJ.
europepmc   +1 more source