Results 111 to 120 of about 3,164 (224)

Fluorescence spectroscopic studies of HSA with withanolide and withanoside molecules, indicating the interaction of the drug with plasma protein. [PDF]

, 2018
The association constant (KS) and free energy change along with stern-volmer plots showing fluorescence quenching constant (kq) and plot of Fo/F against [Q] at λex = 285 nm and λem = 360 nm for (A) withanolide A, (B) withanolide B, (C) withanoside IV and
Arijit Sarkar (5942156), Monika Kallubai (618436), Shreya Dubey (3820303), Rajagopal Subramanyam (297691)   +3 more
core   +1 more source

Withaferin A and Withanolide D Analogues with Dual Heat-Shock-Inducing and Cytotoxic Activities: Semisynthesis and Biological Evaluation [PDF]

, 2018
Withanolides constitute a valuable class of bioactive natural products because some members of the class are known to exhibit cytotoxic activity and also induce a cytoprotective heat-shock response.
Luke Whitesell (477573), Pedro H. J. Batista (4960816), Maria C. F. Oliveira (4960813), Ya-Ming Xu (1344258), E. M. Kithsiri Wijeratne (1324608), Otília D. L. Pessoa (2100214), A. A. Leslie Gunatilaka (243119), Sandro Minguzzi (4960810), Jair Mafezoli (678372)   +8 more
core   +1 more source

Bioactive metabolites from the leaves of Withania adpressa

Pharmaceutical Biology, 2018
Context: Withania (Solanaceae) species are known to be a rich source of withanolides, which have shown several biological properties. Objective: To identify the compounds responsible for Withania adpressa Coss.
Widad Ben Bakrim, Laila El Bouzidi, Jean-Marc Nuzillard, Sylvian Cretton, Noémie Saraux, Aymeric Monteillier, Philippe Christen, Muriel Cuendet, Khalid Bekkouche   +8 more
doaj   +1 more source

Integrative Machine Learning, Virtual Screening, and Molecular Modeling for BacA-Targeted Anti-Biofilm Drug Discovery Against Staphylococcal Infections

Crystals
The rise in antibiotic-resistant Staphylococcal infections necessitates innovative approaches to identify new therapeutic agents. This study investigates the application of machine learning models to identify potential phytochemical inhibitors against ...
Ahmad Almatroudi
doaj   +1 more source

Estimation of withanolide A in diverse genotypes of Ashwagandha Withania somnifera (L.) Dunal [PDF]

, 2019
212-217Withania somnifera (L.) Dunal (Fam. Solanaceae) commonly known as Ashwagandha has been used in traditional Indian medicine system from ancient times. Roots of the plant are being used in the preparation of many Ayurvedic medicines for treatment of
Joshi, Arunabh, Jain, Rohit, Jain, Devendra, Chauhan, Surya   +3 more
core  

Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L.

Beilstein Journal of Organic Chemistry, 2019
Withanolides are steroidal lactones widespread in Nightshade plants with often potent antiproliferative activities. Additionally, the structural diversity of this compound class holds much potential for the discovery of novel biological activity.
Annika Stein, Dave Compera, Bianka Karge, Mark Brönstrup, Jakob Franke   +4 more
doaj   +1 more source

Shoden promotes Relief from stress and anxiety: A randomized, double-blind, placebo-controlled study on healthy subjects with high stress levels

Heliyon
Background: This randomized placebo-controlled study examined the effect of ashwagandha root and leaf extract 60 mg (AE60) and 120 mg (AE120) (35 % withanolide glycosides, Shoden) in physically healthy subjects with higher stress and anxiety.
Deo Nidhi Mishra, Manoj Kumar
doaj   +1 more source

Withanolide glycosides from Physalis volubilis

Fitoterapia
The study of the acetone and methanol extracts of the stems, leaves, and flowers of Physalis volubilis led to obtain four withanolide glycosides (4, 6, 10, and 14). Compounds 1-3, 13, 15, and a sterol glycoside were also isolated. The structures were established by analysis of spectroscopic and spectrometric data, and by chemical transformations.
Ana-L, Pérez-Castorena, Tonantzin G, Anguheven L, M Azucena, Martínez R, Jesús, Morales-Jiménez, Emma, Maldonado, Mahinda, Martínez   +5 more
openaire   +2 more sources

Finding potential inhibitors from phytochemicals against nucleoprotein of crimean congo fever virus using in silico approach

Scientific Reports
The Crimean Congo virus has been reported to be a part of the spherical RNA-enveloped viruses from the Bunyaviridae family. Crimean Congo fever (CCHF) is a fatal disease with having fatality rate of up to 40%.
Muhammad Ramzan, Sajid Mahmood, Adnan Amjad, Mohsin Javed, Ammar Zidan, Ali Bahadur, Shahid Iqbal, Muhammad Saad, Namrah Zaka, Shazia Khurshid, Nasser S. Awwad, Hala A. Ibrahium, Toheed Akhter   +12 more
doaj   +1 more source

Withanolide Compounds as Inhibitors of Fibrosis and Identification of Molecular Targets for Anti-Fibrotic Drug Development [PDF]

, 2012
Provided are methods for screening for drugs effective for treating fibrotic conditions. One screening method comprises exposing a cell to a test compound, monitoring the effect of the test compound on the amount or form of a cell molecule, comparing the
Mohan, Royce, Bargagna-Mohan, Paola
core   +1 more source