Results 131 to 140 of about 23,202,835 (216)

Molecular dynamics simulations reveal the inhibitory mechanism of Withanolide A against α-glucosidase and α-amylase

Journal of Biomolecular Structure and Dynamics, 2022
Diabetes mellitus (DM) is a global chronic disease characterized by hyperglycemia and insulin resistance. The unsavory severe gastrointestinal side-effects of synthetic drugs to regulate hyperglycemia have warranted the search for alternative treatments ...
H. Oyewusi, Y. Wu, S. Safi, R. Wahab, Mohd. Hatta, K. Batumalaie   +5 more
semanticscholar   +1 more source

Induction of stress resistance and extension of lifespan in Chaenorhabditis elegans serotonin-receptor knockout strains by withanolide A.

Phytomedicine, 2021
INTRODUCTION Approximately 300 million people worldwide suffer from depression. The COVID-19 crisis may dramatically increase these numbers. Severe side effects and resistance development limit the use of standard antidepressants.
Janine Naß, Sara Abdelfatah, T. Efferth
semanticscholar   +1 more source

Pharmacology of Withanolide A

, 2017
A. Saroya
semanticscholar   +2 more sources

Withanolides from Discopodium penninervium

Fitoterapia, 2023
Discopodium penninervium is a medicinal plant endemic to Ethiopia. Its twigs extract led to the isolation of three new withanolides, discopodinolides A - C, and four known analogues. The structures of the compounds were elucidated using NMR, HRMS data analyses, and literature data.
Kibrom Gebreheiwot, Bedane, Mekonnen Abebayehu, Desta, Peter, Spiteller   +2 more
openaire   +2 more sources

Computational Evidence to Inhibition of Human Acetyl Cholinesterase by Withanolide A for Alzheimer Treatment

Journal of Biomolecular Structure and Dynamics, 2012
Abhinav Grover, Durai Sundar, Ashutosh Shandilya   +2 more
exaly   +2 more sources

Withanolide-A treatment exerts a neuroprotective effect via inhibiting neuroinflammation in the hippocampus after pilocarpine-induced status epilepticus.

Epilepsy Research, 2020
Status epilepticus (SE) is a medical emergency with high mortality and a risk factor for the development of chronic epilepsy. Given that effective treatments for the pathophysiology following SE are still lacking, suppressing pathophysiological ...
J. Zhu, Soojin Park, K. H. Jeong, Won-Joo Kim   +3 more
semanticscholar   +1 more source

Synthesis of withanolide A depends on carbon source and medium pH in hairy root cultures of Withania somnifera

Industrial Crops and Products, 2012
N Praveen
exaly   +2 more sources

Natural withanolides: an overview

Natural Product Reports, 2011
Withanolides are a group of naturally occurring C28 steroids built on an ergostane skeleton functionalized at carbons 1, 22 and 26, commonly known as the withanolide skeleton. Over the period of August 1996 to March 2010, 360 new naturally occurring withanolides were isolated and identified.
Li-Xia, Chen, Hao, He, Feng, Qiu
openaire   +2 more sources

Trypanocidal Withanolides and Withanolide Glycosides from Dunalia brachyacantha

Journal of Natural Products, 2001
Two new withanolide glycosides, (20R,22R)-O-(3)-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl-1 alpha,12 beta-diacetoxy-20-hydroxywitha-5,24-dienolide (3) and (20R,22R)-O-(3)-beta-D-xylopyranosyl(1-->3)-[beta-D-xylopyranosyl(1-->4)]-beta-D-glucopyranosyl-1 alpha-acetoxy-12 beta,20-dihydroxywitha-5,24-dienolide (4), were isolated from the leaves ...
J A, Bravo B, M, Sauvain, A, Gimenez T, E, Balanza, L, Serani, O, Laprévote, G, Massiot, C, Lavaud   +7 more
openaire   +2 more sources

Withanolide C, A chlorinated withanolide from Withania somnifera

Phytochemistry, 1992
Abstract The structure of a new chlorinated withanolide isolated from Withania somnifera chemotype III has been elucidated as 5α-chloro,6β,14α,17β,2Oα F -tetrahydroxy-l-oxo-22R-witha-2,24-dienolide by 1 H and 13 CNMR and chemical ionization mass spectroscopy methods.
Roberto Bessalle, David Lavie
openaire   +1 more source