Results 151 to 160 of about 23,202,835 (216)

Assessing Digestive Transformations of Withania somnifera Extracts via LC-MS/MS Profiling with a Focus on Bioactive Compounds Withaferin A, Withanolide A, Withanoside IV, and Untargeted Metabolomics.

Journal of Agricultural and Food Chemistry
Botanical extracts are widely employed as health care agents but lack the rigorous vetting required for FDA-approved pharmaceuticals. Research on phytochemical bioavailability and transformation has mainly focused on liver metabolism and plasma binding ...
Sarah A. Barr, Lydia J. Davis, Warren S. Vidar, R. T. Williamson, W. Strangman   +4 more
semanticscholar   +1 more source

Withanolides of Acnistus breviflorus

Phytochemistry, 1981
The chemical examination of Acnistus breviflorus afforded nine withanolides, four of which are new and were established as 2,3,24,25-tetrahydro-27-desoxywithaferin A (4β-hydroxy-5β,6β-epoxy-1-oxo-22 R-withanolide), 2,3-dihydro-27-desoxywithaferin A (4β-hydroxy-5β,6β-epoxy-22 R-witha-24-enolide), 5,6-desoxywithaferin A (4β,27-dihydroxy-1-oxo-22 R-witha ...
S. Sarma Nittala, David Lavie
openaire   +1 more source

Biosynthesis of the triterpenoid withanolides in Withania somnifera

Current Opinion in Plant Biology
Ashwagandha (Withania somnifera L. Dunal) is a versatile medicinal plant of Solanaceae family, renowned for its potent therapeutic properties, due to which it is extensively used in Indian traditional systems of medicine such as Ayurveda. The medicinal properties are attributed to specialized metabolites known as withanolides, which are chemically ...
Ananth Krishna Narayanan, Dinesh A. Nagegowda   +1 more
openaire   +2 more sources

New withanolides from Mandragora officinarum: First report of withanolides from the Genus Mandragora

Fitoterapia, 2010
Two new withanolides named mandragorolide A (1) and mandragorolide B (2) were isolated from the MeOH extract of the whole plant of Mandragora officinarum of Jordanian origin, along with five known withanolides namely larnaxolide A (3), withanolide B (4), datura lactone 2 (5), withanicandrin (6) and salpichrolide C (7). Compound 3 has been reported only
Rami K, Suleiman, Musa Abu, Zarga, Salim S, Sabri   +2 more
openaire   +2 more sources

Withanolides from Physalis hispida

Journal of Natural Products, 2014
Nine new withanolides (1-9), withahisolides A-I, were isolated along with nine known compounds (10-18) from the aerial parts of Physalis hispida. The structures of 1-9 were elucidated through a variety of spectroscopic techniques, while the structures of 1 and 2 were confirmed by X-ray crystallographic analysis. Compounds 1-3 are the first withanolides
Cong-Mei, Cao, Huaping, Zhang, Robert J, Gallagher, Victor W, Day, Kelly, Kindscher, Patrick, Grogan, Mark S, Cohen, Barbara N, Timmermann   +7 more
openaire   +2 more sources

Withanolides of Datura metel

Phytochemistry, 1992
Abstract The leaves of Datura metel yielded three new withanolides in addition to lycium substance B, previously reported from other Datura species. The structures of the withanolides, clarified by comprehensive spectral analysis, showed features of typical daturalactones as well as of the withanolides of D. metel. p -Hydroxy cinnamic acid amide
Mohini Gupta, M. Manickam, Subhash C. Sinha, Anjana Sinha-Bagchi, Anil B. Ray   +4 more
openaire   +1 more source

Antiproliferative Withanolides from Jaborosa Riojana

Fitoterapia
Six previously undescribed withanolides, of which three had a normal glycosylated skeleton (Jaborosalactones 49-51) and three had a sativolide skeleton (12-O-methyl jaborosalactone 52, jaborosalactone 53, and 12-O-methyl jaborosalactone 53), were isolated from the aerial parts of Jaborosa riojana.
Lobatto, Virginia Laura, Casero, Carina Noelia, González Bakker, Aday, Padrón, José M., Nicotra, Viviana Estela   +4 more
openaire   +3 more sources

Withanolides from Ajuga parviflora

Journal of Natural Products, 1999
Two new withanolides named ajugin A [14alpha,20, 28-trihydroxy-1-oxo-(20R,22R)-witha-3,5,24-trienolide] (1) and ajugin B [14alpha,20,27-trihydroxy-1-oxo-(20R,22R)-witha-5, 24-dienolide] (2) were isolated from the whole plant of Ajuga parviflora, and their structures were deduced by NMR and MS analyses.
, Khan, , Malik, , Ahmad, , Nawaz
openaire   +2 more sources

Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing nitric oxide generation.

Journal of Ethnopharmacology, 2021
Priya Pathak, P. Shukla, J. Kanshana, Kumaravelu Jagavelu, N. Sangwan, A. Dwivedi, M. Dikshit   +6 more
semanticscholar   +1 more source

Cytotoxic withanolides from Acnistus arborescens

Phytochemistry, 2002
Three cytotoxic withanolides, two with new structures, were isolated from the leaves of Acnistus arborescens and their structures determined by a combination of 1D and 2D NMR, mass spectral, and molecular modeling studies. Dereplication analysis of the ethyl ether extract was useful for evaluating the components showing significant cytotoxic activity.
Sandro, Minguzzi, Lauro E S, Barata, Young Geun, Shin, Patrick F, Jonas, Hee Byung, Chai, Eun Jung, Park, John M, Pezzuto, Geoffrey A, Cordell   +7 more
openaire   +2 more sources