Results 151 to 160 of about 114,627,962 (212)

Dual targeting of IGF-1R and K-RAS with natural phytochemicals for lung cancer therapy: an in-silico study. [PDF]

J Genet Eng Biotechnol
Ahmed SF, Hossen Z, Chakraborty I, Rahman Munna MM, Chowdhury S, Zaheen A, Tasmin J, Ashraful ABM, Jahin MA, Ahmed MH.   +9 more
europepmc   +1 more source

Subfunctionalization and epigenetic regulation of a biosynthetic gene cluster in <i>Solanaceae</i>. [PDF]

Proc Natl Acad Sci U S A
Priego-Cubero S, Knoch E, Wang Z, Alseekh S, Braun KH, Chapman P, Fernie AR, Liu C, Becker C.   +8 more
europepmc   +1 more source

Withanolide Z, a New Chlorinated Withanolide from Withania somnifera

Planta Medica, 2008
Reverse-phase preparative HPLC analysis of the n-butanol fraction of the methanolic extract of Withania somnifera Dunal (leaves) afforded a novel chlorinated withanolide, namely withanolide Z (1), along with four known withanolides, withanolide B (2 ...
Hemanta K Majumder, Sibabrata Mukhopadhyay   +1 more
exaly   +4 more sources

Some of the next articles are maybe not open access.

Related searches:

Natural withanolides, an update

Natural Product Reports, 2022
This review summarizes the research progress on the structural classification, biological activities and mechanisms, metabolism and pharmacokinetic investigations, biosynthesis, and synthesis and structural modifications of the withanolides.
Gui-yang Xia, Shi-jie Cao, Li-xia Chen, Feng Qiu   +3 more
openaire   +2 more sources

Withanolides from Discopodium penninervium

Fitoterapia, 2023
Discopodium penninervium is a medicinal plant endemic to Ethiopia. Its twigs extract led to the isolation of three new withanolides, discopodinolides A - C, and four known analogues. The structures of the compounds were elucidated using NMR, HRMS data analyses, and literature data.
Kibrom Gebreheiwot, Bedane, Mekonnen Abebayehu, Desta, Peter, Spiteller   +2 more
openaire   +2 more sources

Natural withanolides: an overview

Natural Product Reports, 2011
Withanolides are a group of naturally occurring C28 steroids built on an ergostane skeleton functionalized at carbons 1, 22 and 26, commonly known as the withanolide skeleton. Over the period of August 1996 to March 2010, 360 new naturally occurring withanolides were isolated and identified.
Li-Xia, Chen, Hao, He, Feng, Qiu
openaire   +2 more sources

Trypanocidal Withanolides and Withanolide Glycosides from Dunalia brachyacantha

Journal of Natural Products, 2001
Two new withanolide glycosides, (20R,22R)-O-(3)-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl-1 alpha,12 beta-diacetoxy-20-hydroxywitha-5,24-dienolide (3) and (20R,22R)-O-(3)-beta-D-xylopyranosyl(1-->3)-[beta-D-xylopyranosyl(1-->4)]-beta-D-glucopyranosyl-1 alpha-acetoxy-12 beta,20-dihydroxywitha-5,24-dienolide (4), were isolated from the leaves ...
J A, Bravo B, M, Sauvain, A, Gimenez T, E, Balanza, L, Serani, O, Laprévote, G, Massiot, C, Lavaud   +7 more
openaire   +2 more sources

Natural Bioactive New Withanolides

Mini-Reviews in Medicinal Chemistry, 2020
Withanolides are a group of highly oxygenated steroids derived from a C28 ergostane skeleton, and have attracted significant scientific interest due to their complex structural features and multiple bioactivities. More than 170 new natural withanolides were isolated and identified in the last 5 years.
Qian-Qian, Xu, Kui-Wu, Wang
openaire   +2 more sources

Withanolide C, A chlorinated withanolide from Withania somnifera

Phytochemistry, 1992
Abstract The structure of a new chlorinated withanolide isolated from Withania somnifera chemotype III has been elucidated as 5α-chloro,6β,14α,17β,2Oα F -tetrahydroxy-l-oxo-22R-witha-2,24-dienolide by 1 H and 13 CNMR and chemical ionization mass spectroscopy methods.
Roberto Bessalle, David Lavie
openaire   +1 more source

Withanolide Y, a withanolide from a hybrid of Withania somnifera

Phytochemistry, 1987
Abstract The structure of a withanolide isolated from the hybrid of Withania somnifera chemotype III (Israel) by Indian I (Delhi) has been elucidated as (20R,22R)-5α,6α-epoxy-7α-17α,20-trihydroxy-1-oxo-witha-2,24-dienolide by X-ray single crystal analysis.
Roberto Bessalle, David Lavie, Felix Frolow   +2 more
openaire   +1 more source