Results 141 to 150 of about 23,202,835 (216)

Natural Bioactive New Withanolides

Mini-Reviews in Medicinal Chemistry, 2020
Withanolides are a group of highly oxygenated steroids derived from a C28 ergostane skeleton, and have attracted significant scientific interest due to their complex structural features and multiple bioactivities. More than 170 new natural withanolides were isolated and identified in the last 5 years.
Qian-Qian, Xu, Kui-Wu, Wang
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Withanolide Y, a withanolide from a hybrid of Withania somnifera

Phytochemistry, 1987
Abstract The structure of a withanolide isolated from the hybrid of Withania somnifera chemotype III (Israel) by Indian I (Delhi) has been elucidated as (20R,22R)-5α,6α-epoxy-7α-17α,20-trihydroxy-1-oxo-witha-2,24-dienolide by X-ray single crystal analysis.
Roberto Bessalle, David Lavie, Felix Frolow   +2 more
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Withanolide Z, a New Chlorinated Withanolide fromWithania somnifera

Planta Medica, 2008
Reverse-phase preparative HPLC analysis of the n-butanol fraction of the methanolic extract of Withania somnifera Dunal (leaves) afforded a novel chlorinated withanolide, namely withanolide Z (1), along with four known withanolides, withanolide B (2), withanolide A (3), 27-hydroxywithanolide B (4) and withaferin A (5).
Swapan, Pramanick, Amit, Roy, Shekher, Ghosh, Hemanta K, Majumder, Sibabrata, Mukhopadhyay   +4 more
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Withanolide a penetrates brain via intra-nasal administration and exerts neuroprotection in cerebral ischemia reperfusion injury in mice

Xenobiotica; the fate of foreign compounds in biological systems, 2019
1. Withanolide A (WA), a major constituent phytochemical of the Ayurvedic herb Withania somnifera reportedly combats neurodegeneration in Alzheimer’s disease and Parkinson’s disease.
S. Mukherjee, Gaurav Kumar, R. Patnaik
semanticscholar   +1 more source

Withanolides from Jaborosa kurtzii

Journal of Natural Products, 2007
Two new withanolides were isolated and characterized from the aerial parts of Jaborosa kurtzii, namely, jaborosalactone 43 (1), with a spiranoid delta-lactone at C-22, and jaborosalactone 44 (2), a 12-oxowithanolide, which may function as a biosynthetic precursor to 1.
Natalia S, Ramacciotti, Viviana E, Nicotra   +1 more
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Withanolide Artifacts Formed in Methanol

Journal of Natural Products, 2013
Methanol solutions of the main withanolides (6-8) naturally present in Physalis longifolia yielded five artificial withanolides (1-5), including three new compounds (1-3). Withanolides 1 and 2 were identified as intramolecular Michael addition derivatives, while withanolides 3-5 were the result of intermolecular Michael addition.
Cong-Mei, Cao, Huaping, Zhang, Robert J, Gallagher, Barbara N, Timmermann   +3 more
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Withanolides from Physalis coztomatl

Phytochemistry, 2015
Six withanolides (1-6), as well as two known withanolides (physachenolide D 7 and withanoside VI 8), were isolated from the aerial parts of Physalis coztomatl (Solanaceae). Structural elucidations of 1-6 were achieved through 2D NMR and other spectroscopic techniques, while the structure of 1 was confirmed by X-ray crystallographic analysis.
Zhang, Huaping, Cao, Cong-Mei, Gallagher, Robert J., Day, Victor W., Kindscher, Kelly, Timmermann, Barbara N.   +5 more
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Extraction Optimization for Phenolic- and Withanolide-Rich Fractions from Withania somnifera Roots: Identification and Quantification of Withaferin A, 12-Deoxywithastromonolide, and Withanolide A in Plant Materials and Marketed Formulations Using a Reversed-Phase HPLC-Photodiode Array Detection Meth

Journal of AOAC International, 2018
Background: Both the roots and leaves of Withania somnifera are products of commerce. They contain active compounds of therapeutic value and mostly different withanolides. Several pharmacological activities of W.
Satyanshu Kumar, Raghuraj Singh, N. Gajbhiye, Tushar Dhanani   +3 more
semanticscholar   +1 more source

Determination of permeability, plasma protein binding, blood partitioning, pharmacokinetics and tissue distribution of Withanolide A in rats: A neuroprotective steroidal lactone

Drug development research (Print), 2018
Preclinical Research ...
Sandeep K. Singh, G. Valicherla, P. Joshi, Sudhir Shahi, A. A. Syed, A. Gupta, Zakir Hossain, K. Italiya, Vishal S. Makadia, Shio Kumar Singh, M. Wahajuddin, J. Gayen   +11 more
semanticscholar   +1 more source

Biosynthesis of withanolides in Acnistus breviflorus: biogenetic relationships among the main withanolides

Phytochemistry, 1985
Abstract To excised leaves and 15-day-old seedlings of Acnistus breviflorus sodium [1- 14 C]acetate, [2- 14 C]mevalonolactone and [ 14 C-methyl]methionine were administered in separate experiments. From the absolute incorporation values of withaferin A (1), jaborosalactone A (2) and jaborosalactone D (3) isolated at different times after ...
Adriana S. Veleiro, Gerardo Burton, Eduardo G. Gros   +2 more
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