Results 81 to 90 of about 2,611 (169)

Biological Activity of Withanolides

, 2000
904-911A large number of withanolides are isolated from solanaceous plants and some derivatives are also prepared. Some of the withanolides, mainly Withaferin A(WA),Withanolide D(WD), Withanolide E(WE), 3β- hydroxy-2,3-dihydrowithanolide F, and ...
Budhiraja, R D, Krishan, Pawan, Sudhir, S   +2 more
core  

Ashwagandha Root Extract and Its Potential Modulation of CCN1‐Associated Pathways in Sensitive‐Skin Aging

Journal of Cosmetic Dermatology, Volume 25, Issue 7, July 2026.
ABSTRACT Background Cellular Communication Network Factor 1 (CCN1) has been identified as a key regulator of oxidative stress‐induced skin aging and sensitivity. Ashwagandha root extract (ARE) is a promising candidate for modulating CCN1‐associated pathways. Aims To investigate whether ARE can mitigate sensitive‐skin aging by modulating CCN1 expression
Liying Kang, Yanhong Liu, Yuchen Xin, Lin Geng, Shaochun Cai, Jianfang Luo, Shaojie Gu, Shuangyan Wang, Zhiting Zhang, Yan Huang, Guixuan Zhou, Li Ye, Dongcui Li, Naisheng Jiang   +13 more
wiley   +1 more source

The Effect of Colchicine on Profiles and Contents of Withanolides of Ciplukan (Physalis angulata) In vitro

, 2022
This study aimed to determine the effect of in vitro polyploid induction using colchicine on the content of withanolides in Physalis angulata shoots.
Mastuti, Retno, Munawarti, Aminatun, Afiyanti, Mufidah   +2 more
core   +1 more source

Evaluation of Withaferin A Content in Withania somnifera Using NMR and HPLC: A Comparative Assessment of Traditional and PCSL Extraction Methods

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
A comparative evaluation of traditional aqueous extractions and innovative pressurised cyclic solid–liquid extraction is presented for Withania somnifera leaves. Quantitative NMR, validated by HPLC, reveals a markedly enhanced preservation and recovery of withaferin A using PCSL.
Silvana Pedatella, Maria Chiara Di Meo, Daniele Naviglio, Gionata De Vico, Armando Zarrelli   +4 more
wiley   +1 more source

Antiproliferative Withanolides from Datura wrightii

, 2016
A new withanolide, named withawrightolide (1), and four known withanolides (2–5) were isolated from the aerial parts of Datura wrightii. The structure of compound 1 was elucidated through 2D NMR and other spectroscopic techniques.
Robert J. Gallagher (1828222), Mark S. Cohen (258897), Joseph Bazzill (1884874), Barbara N. Timmermann (1502962), Patrick T. Grogan (1978375), Chitra Subramanian (1978378), Huaping Zhang (1828219), Victor W. Day (1978381), Kelly Kindscher (1502965)   +8 more
core   +1 more source

Callus induction and withanolides production through cell suspension culture of Withania coagulans (Stocks) Dunal

Journal of Medicinal Plants, 2022
Background: Withania coagulans (Stocks) Dunal is a well-known medicinal plant due to its many healing properties. Objective: The aim of the present study was to induce friable callus and subsequently establish the plant cell suspension cultures for the ...
Mohammad Hossein Mirjalili, Hassan Esmaeili   +1 more
doaj  

Deciphering Antidiabetic, Anti‐Inflammatory, and Anti‐Cholinergic Bioactivities of Withania somnifera (L) Dunal Root Extract: An In Vitro and In Silico Investigation

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
In this investigation, Withania somnifera root ethanol extract displays anti‐inflammatory and antidiabetic properties. Though compounds including withasomniferolide B and sitoindoside IX have been previously identified as phytoconstituents in the plant, in silico analysis from this study revealed them as new lead compounds that could act as potential ...
Lufuno Mulelu, Jacqueline N. Manjia, Kolawole A. Olofinsan, Londiwe Xulu, Motlalepula G. Matsabisa   +4 more
wiley   +1 more source

Effect of Ashwagandha Withanolides on Muscle Cell Differentiation

, 2021
Withania somnifera (Ashwagandha) is used in Indian traditional medicine, Ayurveda, and is believed to have a variety of health-promoting effects. The molecular mechanisms and pathways underlying these effects have not yet been sufficiently explored.
Renu Wadhwa, Kejuan Li, Jia Wang, Huayue Zhang, Ashish Kaul, Sunil C. Kaul, Didik Priyandoko   +6 more
core   +1 more source

Metabolites Identification of Bioactive Compounds Daturataturin A, Daturametelin I, N-Trans-Feruloyltyramine, and Cannabisin F From the Seeds of Datura metel in Rats

Frontiers in Pharmacology, 2018
Datura metel L. is a widely used traditional herbal medicine, and withanolides and amides are the two groups of main bioactive constituents in Datura metel seeds.
Silun Xu, Yan Liu, Ling Xiang, Fan Zhou, Hongyu Li, Yongjian Su, Xinyi Xu, Qi Wang   +7 more
doaj   +1 more source

Quantifying Withanolides in Plasma: Pharmacokinetic Studies and Analytical Methods

Withania somnifera (common name: ashwagandha; WS) is an Ayurvedic botanical that has become popular for its reputed effects on stress and insomnia. Research into the bioactive compounds responsible for the biological effects of WS has largely focused on ...
Alex B Speers, Axel Lozano-Ortiz, Amala Soumyanath   +2 more
core   +1 more source