Results 71 to 80 of about 1,755 (175)

Withametelin inhibits TGF-β induced Epithelial-to-Mesenchymal Transition and Programmed-Death Ligand-1 expression in vitro

Frontiers in Oncology
Withanolides are a group of naturally occurring plant-based small molecules known for their wide range of host cellular functions. The anticancer potential of withanolides has been explored in varying cancer cell lines in vitro.
Ashna Fathima, Mohammad Ali Farboodniay Jahromi, Sajeli A. Begum, Trinath Jamma   +3 more
doaj   +1 more source

Liquid chromatography-mass spectrometry quantification of phytochemicals in Withania somnifera using data-dependent acquisition, multiple-reaction-monitoring, and parallel-reaction-monitoring with an inclusion list

Frontiers in Chemistry
Characterization of botanical extracts by mass spectrometry-based metabolomics analysis helps in determining the phytochemical composition that underlies their bioactivity and potential health benefits, while also supporting reproducibility of effects in
Luke C. Marney, Luke C. Marney, Jaewoo Choi, Jaewoo Choi, Armando Alcazar Magana, Armando Alcazar Magana, Armando Alcazar Magana, Liping Yang, Liping Yang, Natascha Techen, Natascha Techen, Md Nure Alam, Md Nure Alam, Mikah Brandes, Mikah Brandes, Amala Soumyanath, Amala Soumyanath, Jan F. Stevens, Jan F. Stevens, Jan F. Stevens, Claudia S. Maier, Claudia S. Maier, Claudia S. Maier   +22 more
doaj   +1 more source

Chimpanzee-Guided Discovery of a Non-Native Bioactive Plant

Animals
Studies on chimpanzees suggest that some plants are consumed for their biological properties. Low frequency of consumption, small ingested quantities, complex food processing for a low nutritional value, and local ecological knowledge from human ...
Sabrina Krief, Hugo Magaldi, Myriam Kourdourli, Marc Jeanson, Raymond Katumba, Harold Rugonge, John Justice Tibesigwa, Marc Litaudon, Florent Olivon   +8 more
doaj   +1 more source

Bioactive metabolites from the leaves of Withania adpressa

Pharmaceutical Biology, 2018
Context: Withania (Solanaceae) species are known to be a rich source of withanolides, which have shown several biological properties. Objective: To identify the compounds responsible for Withania adpressa Coss.
Widad Ben Bakrim, Laila El Bouzidi, Jean-Marc Nuzillard, Sylvian Cretton, Noémie Saraux, Aymeric Monteillier, Philippe Christen, Muriel Cuendet, Khalid Bekkouche   +8 more
doaj   +1 more source

Molecular Modelling of Withanolides Against EP2 Receptor for Treatment of Endometrial Cancer: A Pharmacokinetic and Molecular Docking Study

Chemistry Proceedings
Endometrial cancer is one of the most common gynecological cancers, with new global cases of approximately 420,000 new cases and 98,000 global deaths annually.
Grace Adaji, Asmau Nasir Hamza
doaj   +1 more source

Withanolide glycosides from Physalis volubilis

Fitoterapia
The study of the acetone and methanol extracts of the stems, leaves, and flowers of Physalis volubilis led to obtain four withanolide glycosides (4, 6, 10, and 14). Compounds 1-3, 13, 15, and a sterol glycoside were also isolated. The structures were established by analysis of spectroscopic and spectrometric data, and by chemical transformations.
Ana-L, Pérez-Castorena, Tonantzin G, Anguheven L, M Azucena, Martínez R, Jesús, Morales-Jiménez, Emma, Maldonado, Mahinda, Martínez   +5 more
openaire   +2 more sources

Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review

Plants
Withania somnifera (L.) Dunal is a medicinal plant belonging to the traditional Indian medical system, showing various therapeutic effects such as anti-cancer, anti-inflammatory, anti-microbial, anti-diabetic, and hepatoprotective activity.
Valentina Lerose, Maria Ponticelli, Nadia Benedetto, Vittorio Carlucci, Ludovica Lela, Nikolay T. Tzvetkov, Luigi Milella   +6 more
doaj   +1 more source

Withanolides of Datura stramonium [PDF]

Chemistry of Natural Compounds, 1976
R. N. Tursunova, V. A. Maslennikova, N. K. Abubakirov   +2 more
openaire   +1 more source

Withanolides Are Detected in Human Urine Following Oral Administration of a <i>Withania somnifera</i> Product. [PDF]

Int J Mol Sci
Speers AB, Limoico ED, Lozano-Ortiz A, Marney L, Choi J, Barr SA, Williamson RT, Strangman WK, Maier CS, Soumyanath A.   +9 more
europepmc   +1 more source

Back to the Roots: Safety and Tolerability of Standardised Ashwagandha (<i>Withania somnifera</i>) Root Extract in Healthy Adults-A Systematic Review of Biomarkers and Adverse Events. [PDF]

Pharmaceuticals (Basel)
Coope OC, Willems MET, Levington A, Tallon MJ, Roman-Viñas B, Spurr TJ.   +5 more
europepmc   +1 more source