Results 71 to 80 of about 2,611 (169)

Ashwagandha: Is It Safe? Part 1: A Regulatory Review

Phytotherapy Research, Volume 40, Issue 8, Page 4845-4857, August 2026.
ABSTRACT Over the last decade, ashwagandha ( Withania somnifera (L.) Dunal, AS) has been brought under increasing scrutiny by EU regulators regarding its safety for the use in food supplements, culminating in a recent recommendation for an Article 8 procedure according to Regulation (EC) No. 1925/2006 in the European Union (EU).
T. Brendler, R. Al‐Mondhiry, L. Lang, R. Marles, M. Tallon, A. Raghu   +5 more
wiley   +1 more source

Chlorinated Withanolides from Withania somnifera [PDF]

, 2011
A chlorinated withanolide, 6α-chloro-5β,17α-dihydroxywithaferin A (1), and nine known withanolides, 6α-chloro-5β-hydroxywithaferin A (2), (22R)-5β-formyl-6β,27-dihydroxy-1-oxo-4-norwith-24-enolide, withaferin A, 2,3-dihydrowithaferin A, 3-methoxy-2,3 ...
Timmermann, Barbara N., Tong, Xiaoqin, Zhang, Huaping, Huaping Zhang, Xiaoqin Tong, Barbara N. Timmermann   +5 more
core   +1 more source

Cytotoxic Withanolides From Acnistus Arborescens.

, 2015
Three cytotoxic withanolides, two with new structures, were isolated from the leaves of Acnistus arborescens and their structures determined by a combination of 1D and 2D NMR, mass spectral, and molecular modeling studies.
Cordell, Geoffrey A, Pezzuto, John M, Jonas, Patrick F, Minguzzi, Sandro, Shin, Young Geun, Chai, Hee Byung, Barata, Lauro E S, Park, Eun Jung   +7 more
core   +2 more sources

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, Volume 40, Issue 8, Page 4880-4897, August 2026.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Parameters affecting microwave-assisted extraction of withanolides

, 2001
Focused microwave-assisted extraction was applied to the extraction of three main withanolides from airdried leaves of Iochroma gesnerioides, namely, withaferin A, iochromolide and withacnistin. Six extraction variables, i.e.
Christen, Philippe, Kaufmann, Béatrice, Veuthey, Jean-Luc   +2 more
core   +1 more source

Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha ( Withania somnifera )

Phytotherapy Research, Volume 40, Issue 8, Page 5030-5047, August 2026.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan, Candace L. Doepker, Gregory P. Brorby   +2 more
wiley   +1 more source

Withanolides from Physalis hispida

, 2016
Nine new withanolides (1–9), withahisolides A–I, were isolated along with nine known compounds (10–18) from the aerial parts of Physalis hispida. The structures of 1–9 were elucidated through a variety of spectroscopic techniques, while the structures of
Robert J. Gallagher (1828222), Mark S. Cohen (258897), Victor W. Day (1312500), Barbara N. Timmermann (1502962), Patrick Grogan (1828216), Huaping Zhang (1828219), Cong-Mei Cao (228099), Kelly Kindscher (1502965)   +7 more
core   +1 more source

Influence of Drying on the quality of Ashwagandha (Withania somnifera)

Journal of Food and Pharmaceutical Sciences, 2014
An experiment was carried out to adjudge the effect of different drying techniques on colour and withanolides content of Withania somnifera. Withania somnifera (Ashwagandha) is a plant used in medicine from the time of Ayurveda, the ancient system of ...
A Agrawal
doaj  

Safety of 8‐Week Administration With Ashwagandha (Withania somnifera) Root Extract in Adults With Stress and Anxiety: Findings From a Prospective, Randomized, Multi‐Center, Double‐Blinded, Placebo‐Controlled Study

Phytotherapy Research, Volume 40, Issue 8, Page 5005-5015, August 2026.
ABSTRACT Ashwagandha ( Withania somnifera ) has been recognized for enhancing physical strength, mental well‐being, and overall vitality. Despite its long‐standing use across generations, some clinical reports have noted occasional adverse events. This study compared the safety and tolerability of Ashwagandha Root Extract (ARE) in healthy adults.
Ketan Pakhale, Jaising Salve, John Ademola, Jose Parraca, Deepak Langade   +4 more
wiley   +1 more source

Laser‐Enabled Biotechnology Platforms for Climate‐Resilient Crop Production: Mechanistic Insights and Future Prospects

Food and Energy Security, Volume 15, Issue 4, July/August 2026.
ABSTRACT Climate change poses a major threat to global food security through extreme weather events, expanding pathogen ranges, and increased agrochemical dependency. This review highlights the emerging role of laser biotechnology as a sustainable and precise strategy to enhance crop resilience and productivity under climate stress.
Temoor Ahmed, Yumeng Lei, Muhammad Noman, Zhitao Li, Gabrijel Ondrasek, Muhammad Shafiq Shahid, Branko Petrinec, Xingjiang Qi, Bin Li, Yetong Qi   +9 more
wiley   +1 more source