Results 21 to 30 of about 1,755 (175)

Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway

Molecules, 2019
Psoriasis is an immune-mediated inflammatory dermatosis characterized by epidermal hyperplasia and excessive infiltration of inflammatory cells. Withanolides, extracted from Datura metel L.; are the main effective components for the treatment of ...
Tingting Li, Zheng Wei, Yanping Sun, Qiuhong Wang, Haixue Kuang   +4 more
doaj   +1 more source

UPLC-MS/MS Identification and Quantification of Withanolides from Six Parts of the Medicinal Plant Datura Metel L.

Molecules, 2020
Withanolides from six parts (flower, leaf, stem, root, seed, and peel) of Datura metel L. (D metel L.) obtained from ten production areas in China were identified and quantified by UPLC-MS/MS.
Shi Hui Yang, Yan Liu, Qi Wang, Yan Ping Sun, Wei Guan, Yuan Liu, Bing You Yang, Hai Xue Kuang   +7 more
doaj   +1 more source

Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera)

Journal of Ginseng Research, 2022
Background: Withania somnifera (Solanaceae), generally known as Indian ginseng, is a medicinal plant that is used in Ayurvedic practice for promoting health and longevity.
Seoung Rak Lee, Bum Soo Lee, Jae Sik Yu, Heesun Kang, Min Jeong Yoo, Sang Ah Yi, Jeung-Whan Han, Sil Kim, Jung Kyu Kim, Jin-Chul Kim, Ki Hyun Kim   +10 more
doaj   +1 more source

Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically Grown Physalis coztomatl

Molecules, 2022
Withanolides constitute one of the most interesting classes of natural products due to their diversity of structures and biological activities. Our recent studies on withanolides obtained from plants of Solanaceae including Withania somnifera and a ...
Ya-Ming Xu, E. M. Kithsiri Wijeratne, Manping X. Liu, Lijiang Xuan, Wenqiong Wang, A. A. Leslie Gunatilaka   +5 more
doaj   +1 more source

Withanolide Metabolites Inhibit PI3K/AKT and MAPK Pro-Survival Pathways and Induce Apoptosis in Acute Myeloid Leukemia Cells

Biomedicines, 2020
Acute myeloid leukemia (AML) is an aggressive disease and, despite advances, its treatment remains challenging. Therefore, it remains important to identify new agents for the management of this disease.
Nosheen Akhtar, Muhammad Waleed Baig, Ihsan-ul Haq, Vinothini Rajeeve, Pedro Rodriguez Cutillas   +4 more
doaj   +1 more source

Evaluating anticancer properties of Withaferin A—a potent phytochemical

Frontiers in Pharmacology, 2022
Withaferin A is a C28 steroidal lactone derived from the plant Withania somnifera, commonly known as Ashwagandha. Withaferin A has received great attention for its anticancer properties noted in cancer cells of various origins.
Maushma Atteeq
doaj   +1 more source

Oxidative Stress and AKT-Associated Angiogenesis in a Zebrafish Model and Its Potential Application for Withanolides

Cells, 2022
Oxidative stress and the AKT serine/threonine kinase (AKT) signaling pathway are essential regulators in cellular migration, metastasis, and angiogenesis.
Jen-Yang Tang, Yuan-Bin Cheng, Ya-Ting Chuang, Kun-Han Yang, Fang-Rong Chang, Wangta Liu, Hsueh-Wei Chang   +6 more
doaj   +1 more source

Induction of Quinone Reductase by Withanolides

Journal of Natural Products, 2002
Thirty-seven naturally occurring withanolides (1-37), previously isolated in our laboratories, were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells (Hepa 1c1c7). Spiranoid (29, 32) and 18-functionalized withanolides (2-5, 7-9, 24) were found to be potent inducers of the enzyme, while 5alpha-substituted ...
Misico, Rosana Isabel, Song, Lynda L., Veleiro, Adriana Silvia, Cirigliano, Adriana Monica, Tettamanzi, María C., Burton, Gerardo, Bonetto, Gloria Maria, Nicotra, Viviana Estela, Silva, Gloria L., Gil, Roberto Ricardo, Oberti, Juan Carlos María, Kinghorn, A. Douglas, Pezzuto, John   +12 more
openaire   +3 more sources

Evaluation of the bioavailability of major withanolides of Withania somnifera using an in vitro absorption model system

Journal of Advanced Pharmaceutical Technology & Research, 2015
Withania somnifera (L.) Dunal, shows several pharmacological properties which are attributed mainly to the withanolides present in the root. The efficacy of medicinally active withanolides constituents depends on the absorption and transportation through
Santosh T Devkar, Amit D Kandhare, Brian D Sloley, Suresh D Jagtap, James Lin, Yun K Tam, Surendra S Katyare, Subhash L Bodhankar, Mahabaleshwar V Hegde   +8 more
doaj   +1 more source

Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L.

Beilstein Journal of Organic Chemistry, 2019
Withanolides are steroidal lactones widespread in Nightshade plants with often potent antiproliferative activities. Additionally, the structural diversity of this compound class holds much potential for the discovery of novel biological activity.
Annika Stein, Dave Compera, Bianka Karge, Mark Brönstrup, Jakob Franke   +4 more
doaj   +1 more source