Results 21 to 30 of about 2,611 (169)
Leishmanicidal Activity of Withanolides from Aureliana Fasciculata var. Fasciculata
Molecules, 2018 Leishmaniasis is the generic denomination to the neglected diseases caused by more than 20 species of protozoa belonging to the genus Leishmania. The toxic and parenteral-delivered pentavalent antimonials remain to be the first-line treatment.
Simone Cristina de M. Lima +7 more
doaj +2 more sources
Cytotoxic Withanolides from the Whole Herb of Physalis angulata L.
Molecules, 2019 Physalis angulata L. is a medicinal plant of the Solanaceae family, which is used to produce a variety of steroids. The present study reports on the cytotoxic withanolides of this plant. The species of Physalis angulata L. was identified by DNA barcoding
Qinghong Meng +9 more
doaj +2 more sources
Randomized, Double-Blind, Crossover Study Comparing the Bioavailability of 4 Ashwagandha (Withania somnifera (L.) Dunal) Extracts in Healthy Adults Under Fasting Condition [PDF]
Current Therapeutic ResearchBackground: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is a well-known plant in ayurvedic medicine, widely valued for its therapeutic potential. Although numerous clinical studies have explored its diverse health benefits, limited data
Priyank Rathi, MD, Se-Kwon Kim, PhD
doaj +2 more sources
Divergent synthesis of complex withanolides enabled by a scalable route and late-stage functionalization. [PDF]
, 2023 Withanolides are a group of naturally occurring C28 steroids based on an ergostane skeleton. They possess a high degree of polyoxygenation, and the abundance of O-functional groups has enabled various natural alterations to both the carbocyclic skeleton ...
Wen, Che +3 more
core +2 more sources
Withanolides: Elucidating steroidal lactone biosynthesis in Nightshades [PDF]
, 2022 Withania somnifera (Solanaceae) is well known in ayurvedic medicine as a strengthening tonic for various medical purposes. Its effects are mainly due to withanolides, a class of steroidal lactones with diverse oxidation patterns present in various ...
Stein, Annika
core +1 more source
Molecules, 2020 Withanolides from six parts (flower, leaf, stem, root, seed, and peel) of Datura metel L. (D metel L.) obtained from ten production areas in China were identified and quantified by UPLC-MS/MS.
Shi Hui Yang +7 more
doaj +1 more source
Biomedicines, 2020 Acute myeloid leukemia (AML) is an aggressive disease and, despite advances, its treatment remains challenging. Therefore, it remains important to identify new agents for the management of this disease.
Nosheen Akhtar +4 more
doaj +1 more source
Evaluating anticancer properties of Withaferin A—a potent phytochemical
Frontiers in Pharmacology, 2022 Withaferin A is a C28 steroidal lactone derived from the plant Withania somnifera, commonly known as Ashwagandha. Withaferin A has received great attention for its anticancer properties noted in cancer cells of various origins.
Maushma Atteeq
doaj +1 more source
Cells, 2022 Oxidative stress and the AKT serine/threonine kinase (AKT) signaling pathway are essential regulators in cellular migration, metastasis, and angiogenesis.
Jen-Yang Tang +6 more
doaj +1 more source
Withanolides from Jaborosa caulescens var. bipinnatifida [PDF]
, 2013 Two new withanolides 2,3-dihydrotrechonolide A (1) and 2,3-dihydro-21-hydroxytrechonolide A (2) were isolated along with two known withanolides trechonolide A (3) and jaborosalactone 39 (4) from Jaborosa caulescens var. bipinnatifida (Solanaceae).
Timmermann, Barbara N. +6 more
core +1 more source