Results 21 to 30 of about 2,412 (209)

QUANTITIVE EVOLUTION OF WITHANOLIDES CONTENT OF EGYPTIAN WITHANIA SOMNIFERA (L.) ROOTS. [PDF]

open access: yesAl-Azhar Journal of Pharmaceutical Sciences, 2013
Withanolides are important secondary metabolite in Withania somnifera (L.), which have high medicinal values and possess potent anti-tumor and antioxidant properties.
Said Ismail
doaj   +1 more source

Safety and Tolerability of <i>Withania somnifera</i> Root Extract in Healthy Male Participants: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial. [PDF]

open access: yesFood Sci Nutr
Withania somnifera (WS) or Ashwagandha is valued for its anti‐inflammatory, antioxidant, adaptogenic, and memory‐enhancing properties. This randomized, placebo‐controlled and double‐blind study assessed the safety of standardized WS root extract in healthy adult participants over 180 days. The study concluded that WS root extract (200 mg capsules twice
Vaidya N   +7 more
europepmc   +2 more sources

Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. [PDF]

open access: yesPLoS ONE, 2014
The present study investigated the biosynthesis of major and minor withanolides of Withania somnifera in cell suspension culture using shake-flask culture and bioreactor by exploiting elicitation and precursor feeding strategies.
Ganeshan Sivanandhan   +3 more
doaj   +1 more source

Genetic analysis for yield and quality contributing parameters in ashwagandha [Withania somnifera (L.) Dunal]

open access: yesElectronic Journal of Plant Breeding, 2023
Fourty-eight ashwagandha [Withania somnifera (L.) Dunal] genotypes were studied for the genetic variability, heritability and trait association during 2018-19 based on 13 yield and quality traits. For all the 13 characters studied, highly significant
Venna Santhosh1,3*, B. Prem Kumar2 , B. Pratibha3 , L. Sampath4 and Akarsh Parihar3
doaj   +1 more source

Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2020
Withania somnifera L. is a multipurpose medicinal plant of family Solanaceae occurring abundantly in sub-tropical regions of the world. The folk healers used the plant to treat several diseases such as fever, cancer, asthma, diabetes, ulcer, hepatitis ...
Sumaira Saleem   +4 more
doaj   +1 more source

Quantifying Withanolides in Plasma: Pharmacokinetic Studies and Analytical Methods. [PDF]

open access: yesNutrients
Withania somnifera (common name: ashwagandha; WS) is an Ayurvedic botanical that has become popular for its reputed effects on stress and insomnia. Research into the bioactive compounds responsible for the biological effects of WS has largely focused on ...
Speers AB, Lozano-Ortiz A, Soumyanath A.
europepmc   +2 more sources

Divergent synthesis of complex withanolides enabled by a scalable route and late-stage functionalization.

open access: yes, 2023
Withanolides are a group of naturally occurring C28 steroids based on an ergostane skeleton. They possess a high degree of polyoxygenation, and the abundance of O-functional groups has enabled various natural alterations to both the carbocyclic skeleton ...
Wen, Che   +3 more
core   +1 more source

Withanolides: Elucidating steroidal lactone biosynthesis in Nightshades

open access: yes, 2022
Withania somnifera (Solanaceae) is well known in ayurvedic medicine as a strengthening tonic for various medical purposes. Its effects are mainly due to withanolides, a class of steroidal lactones with diverse oxidation patterns present in various ...
Stein, Annika
core   +1 more source

Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway

open access: yesMolecules, 2019
Psoriasis is an immune-mediated inflammatory dermatosis characterized by epidermal hyperplasia and excessive infiltration of inflammatory cells. Withanolides, extracted from Datura metel L.; are the main effective components for the treatment of ...
Tingting Li   +4 more
doaj   +1 more source

UPLC-MS/MS Identification and Quantification of Withanolides from Six Parts of the Medicinal Plant Datura Metel L.

open access: yesMolecules, 2020
Withanolides from six parts (flower, leaf, stem, root, seed, and peel) of Datura metel L. (D metel L.) obtained from ten production areas in China were identified and quantified by UPLC-MS/MS.
Shi Hui Yang   +7 more
doaj   +1 more source

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