Results 51 to 60 of about 1,362,016 (348)

Is It Me or You?—How Reactions to Abusive Supervision Are Shaped by Leader Behavior and Follower Perceptions

open access: yesFrontiers in Psychology, 2018
There is a growing interest in understanding how follower reactions toward abusive leadership are shaped by followers' perceptions and attributions.
Birgit Schyns   +2 more
doaj   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

Molecular and long-term behavioral consequences of neonatal opioid exposure and withdrawal in mice

open access: yesFrontiers in Behavioral Neuroscience, 2023
IntroductionInfants exposed to opioids in utero are at high risk of exhibiting Neonatal Opioid Withdrawal Syndrome (NOWS), a combination of somatic withdrawal symptoms including high pitched crying, sleeplessness, irritability, gastrointestinal distress,
Amelia D. Dunn   +15 more
doaj   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Brain Metal Distribution and Neuro-Inflammatory Profiles after Chronic Vanadium Administration and Withdrawal in Mice

open access: yesFrontiers in Neuroanatomy, 2017
Vanadium is a potentially toxic environmental pollutant and induces oxidative damage in biological systems including the central nervous system (CNS). Its deposition in brain tissue may be involved in the pathogenesis of certain neurological disorders ...
Oluwabusayo R. Folarin   +5 more
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Withdrawal Symptoms Following Discontinuation of Vortioxetine—Retrospective Chart Review

open access: yesPharmaceuticals, 2021
The efficacy of vortioxetine has been proven in many studies, but data concerning discontinuation symptoms (DS) after vortioxetine withdrawal is scarce.
Marcin Siwek   +4 more
doaj   +1 more source

Towards better understanding of factors contributing to medical physicist well‐being in academic medical centers: A systems‐analysis approach

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract The well‐being of medical physicists can impact overall system performance, patient safety, and quality of patient care. There are limited formal assessments of factors contributing to physicists well‐being. Nine medical physicists at a US academic medical center were surveyed on 21 workplace factors, drawn from the National Academy of ...
Elizabeth Kwong   +13 more
wiley   +1 more source

Uso de metadona para el destete de sedación en paciente pediátrico

open access: yesRevista Electrónica de AnestesiaR, 2019
Los opioides usados  durante más de cinco días, para sedación en paciente pediátrico, deben ser retirado de forma progresiva con el objetivo de prevenir abstinencia.
Rubén Ferreras Vega   +3 more
doaj   +1 more source

A Focus on Abuse/Misuse and Withdrawal Issues with Selective Serotonin Reuptake Inhibitors (SSRIs): Analysis of Both the European EMA and the US FAERS Pharmacovigilance Databases

open access: yesPharmaceuticals, 2022
Despite increasing reports, antidepressant (AD) misuse and dependence remain underestimated issues, possibly due to limited epidemiological and pharmacovigilance evidence.
Stefania Chiappini   +5 more
doaj   +1 more source

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