Results 41 to 50 of about 1,445,344 (302)

Brexit and the EU Constitutional Order: A Three Act Tragedy

open access: yesCroatian Yearbook of European Law and Policy, 2016
This paper reflects upon the consequences of Brexit for the EU constitutional order. It joins many analyses that followed the referendum by which the UK citizens decided that their country should leave the EU.
Tamara Ćapeta
doaj   +1 more source

Value withdrawal explanations: a theoretical tool for programming environments [PDF]

open access: yes, 2002
Constraint logic programming combines declarativity and efficiency thanks to constraint solvers implemented for specific domains. Value withdrawal explanations have been efficiently used in several constraints programming environments but there does not ...
Lesaint, Willy
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Is It Me or You?—How Reactions to Abusive Supervision Are Shaped by Leader Behavior and Follower Perceptions

open access: yesFrontiers in Psychology, 2018
There is a growing interest in understanding how follower reactions toward abusive leadership are shaped by followers' perceptions and attributions.
Birgit Schyns   +2 more
doaj   +1 more source

Nicotine Addiction: Neurobiology and Mechanism

open access: yesJournal of Pharmacopuncture, 2020
Nicotine, primary component of tobaco produces craving and withdrawal effect both in humans and animals. Nicotine shows a close resemblance to other addictive drugs in molecular, neuroanatomical and pharmacological, particularly the drugs which enhances ...
Raj Kumar Tiwari   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Assessment of the possible health risks associated with the consumption of botanical preparations of Mitragyna speciosa (kratom)

open access: yesEFSA Journal, 2022
The current report summarises the work performed in the context of the European Food Risk Assessment Fellowship Programme (EU‐FORA), which included the evaluation of health risks associated with the consumption of botanical preparations of Mitragyna ...
Georgia Papadi   +2 more
doaj   +1 more source

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. [PDF]

open access: yes, 2012
The altered metabolism of cancer can render cells dependent on the availability of metabolic substrates for viability. Investigating the signaling mechanisms underlying cell death in cells dependent upon glucose for survival, we demonstrate that glucose ...
Graeber, Thomas G   +12 more
core  

Behavioural inhibition and valuation of gain/loss are neurally distinct from approach/withdrawal [PDF]

open access: yes, 2019
Gain or omission/termination of loss produces approach; while loss or omission/termination of gain produces withdrawal. Control of approach/withdrawal motivation is distinct from valuation of gain/loss and does not entail learning – making “reward” and ...
Corr, P. J., McNaughton, N.
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

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