Pharmaceuticals, 2022 Despite increasing reports, antidepressant (AD) misuse and dependence remain underestimated issues, possibly due to limited epidemiological and pharmacovigilance evidence.
Stefania Chiappini +5 more
doaj +1 more source
A students' perspective of the effect of withdrawal programming in New Zealand primary schools : a thesis presented in partial fulfillment of the requirements for the degree of Masters in Education at Massey University [PDF]
, 2006 Gifted and talented students have a voice and their own perceptions of their involvement in programmes aimed at catering for their unique abilities.
Walsh, Corinne Louise
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Uso de metadona para el destete de sedación en paciente pediátrico
Revista Electrónica de AnestesiaR, 2019 Los opioides usados durante más de cinco días, para sedación en paciente pediátrico, deben ser retirado de forma progresiva con el objetivo de prevenir abstinencia.
Rubén Ferreras Vega +3 more
doaj +1 more source
From consumption to withdrawal: A broad synopsis of the effects of alcohol
Medicine Advances, 2023 The consumption of alcohol reflects both societal norms and personal choices and has major clinical implications. Long‐term excess alcohol consumption leads to a domino effect of pathological outcomes and onset of chronic illness.
Jun Zhu +6 more
doaj +1 more source
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]
, 2017 Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe +10 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Über die Brunnentiefe eines Rätsels. Anmerkungen zur Frage nach der Tiefe des menschlichen Daseins im Denken Martin Heideggers [PDF]
PhainomenaOn the Well Depth of an Enigma. Notes on the Question of the Depth of Human Existence in Martin Heidegger’s Thought - Heidegger did not conceive a “theory” of depth, but his ways of thinking may be characterized by his own withdrawal into the ...
Johannes Vorlaufer
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Acta Dermato-Venereologica, 2022 In clinical practice, interruption of treatment may not result in immediate cessation of disease control, and some patients even experience sustained treatment response following treatment interruption.
Kim Papp +9 more
doaj +1 more source