Results 71 to 80 of about 1,445,344 (302)

Progress toward pharmacotherapies for cannabis-use disorder: an evidence-based review

Substance Abuse and Rehabilitation, 2016
Jan Copeland, Izabella Pokorski UNSW Medicine, University of New South Wales, Sydney, NSW, Australia Abstract: Cannabis is the most widely used and variably regulated drug in the world, with increasing trends of use being reported in the US, Australia ...
Copel, J, Pokorski I
doaj  

Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes

Frontiers in Pharmacology, 2018
Ibogaine may be effective for transitioning opioid and cocaine dependent individuals to sobriety. American and European self-help groups provided public testimonials that ibogaine alleviated drug craving and opioid withdrawal symptoms after only a single
Deborah C. Mash, Deborah C. Mash, Linda Duque, Bryan Page, Kathleen Allen-Ferdinand   +4 more
doaj   +1 more source

WITHDRAWAL SYNDROMES

Emergency Medicine Clinics of North America, 2000
The pathophysiology of substance withdrawal is elucidated by a review of classic and cutting-edge research. The manifestation and evaluation of the associated withdrawal syndromes from ethanol, sedative-hypnotics, opioids, and baclofen, are compared. The general management of and pharmacotherapy for these patients are discussed.
R, Olmedo, R S, Hoffman
openaire   +2 more sources

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Neonatal Drug Withdrawal [PDF]

Pediatrics, 2012
Maternal use of certain drugs during pregnancy can result in transient neonatal signs consistent with withdrawal or acute toxicity or cause sustained signs consistent with a lasting drug effect. In addition, hospitalized infants who are treated with opioids or benzodiazepines to provide analgesia or sedation may be at risk for manifesting signs of ...
Hudak, Mark L., Tan, Rosemarie C., Frattarelli, Daniel A.C., Galinkin, Jeffrey L., Green, Thomas P., Neville, Kathleen A., Paul, Ian M., Van Den Anker, John N., Hegenbarth, Mary, Knight, Matthew, Shaddy, Robert E., Snodgrass, Wayne R., Alexander, John J., Chescheir, Nancy C., Cragan, Janet D., Rieder, Michael J., Robb, Adelaide, Sachs, Hari C., Zajicek, Anne, Giacoia, George P., Del Monte, Mark, Koteras, Raymond J., Papile, Lu Ann, Baley, Jill E., Bhutani, Vinod K., Carlo, Waldemar A.   +25 more
openaire   +4 more sources

Variable Annuity with GMWB: surrender or not, that is the question

, 2015
Under the optimal withdrawal strategy of a policyholder, the pricing of variable annuities with Guaranteed Minimum Withdrawal Benefit (GMWB) is an optimal stochastic control problem. The surrender feature available in marketed products allows termination
Luo, Xiaolin, Shevchenko, Pavel
core   +1 more source

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source

Turtle Flexion Reflex Motor Patterns Show Windup, Mediated Partly by L-type Calcium Channels

Frontiers in Neural Circuits, 2017
Windup is a form of multisecond temporal summation in which identical stimuli, delivered seconds apart, trigger increasingly strong neuronal responses. L-type Ca2+ channels have been shown to play an important role in the production of windup of spinal ...
Keith P. Johnson, Stephen M. Tran, Emily A. Siegrist, Krishna B. Paidimarri, Matthew S. Elson, Ari Berkowitz, Ari Berkowitz   +6 more
doaj   +1 more source

Liquid interfaces in viscous straining flows: Numerical studies of the selective withdrawal transition [PDF]

, 2007
This paper presents a numerical analysis of the transition from selective withdrawal to viscous entrainment. In our model problem, an interface between two immiscible layers of equal viscosity is deformed by an axisymmetric withdrawal flow, which is ...
Berkenbusch, Marko Kleine, Cohen, Itai, Zhang, Wendy W.   +2 more
core   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source