Results 61 to 70 of about 692,535 (307)
Uso de metadona para el destete de sedación en paciente pediátrico
Revista Electrónica de AnestesiaR, 2019 Los opioides usados durante más de cinco días, para sedación en paciente pediátrico, deben ser retirado de forma progresiva con el objetivo de prevenir abstinencia.
Rubén Ferreras Vega +3 more
doaj +1 more source
From consumption to withdrawal: A broad synopsis of the effects of alcohol
Medicine Advances, 2023 The consumption of alcohol reflects both societal norms and personal choices and has major clinical implications. Long‐term excess alcohol consumption leads to a domino effect of pathological outcomes and onset of chronic illness.
Jun Zhu +6 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
lanec-unifesspa/etoh-withdrawal: Data on NOS-2
, 2020 Data packages for the research project "Behavioral and biochemical effects of ethanol withdrawal in ...
Laboratório de Neurociências e Comportamento "Frederico Guilherme Graeff"
core +1 more source
Über die Brunnentiefe eines Rätsels. Anmerkungen zur Frage nach der Tiefe des menschlichen Daseins im Denken Martin Heideggers [PDF]
PhainomenaOn the Well Depth of an Enigma. Notes on the Question of the Depth of Human Existence in Martin Heidegger’s Thought - Heidegger did not conceive a “theory” of depth, but his ways of thinking may be characterized by his own withdrawal into the ...
Johannes Vorlaufer
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Acta Dermato-Venereologica, 2022 In clinical practice, interruption of treatment may not result in immediate cessation of disease control, and some patients even experience sustained treatment response following treatment interruption.
Kim Papp +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular and long-term behavioral consequences of neonatal opioid exposure and withdrawal in mice
Frontiers in Behavioral Neuroscience, 2023 IntroductionInfants exposed to opioids in utero are at high risk of exhibiting Neonatal Opioid Withdrawal Syndrome (NOWS), a combination of somatic withdrawal symptoms including high pitched crying, sleeplessness, irritability, gastrointestinal distress,
Amelia D. Dunn +15 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source