Results 251 to 260 of about 291,899 (358)

Effects of Hepatic or Renal Impairment on Pharmacokinetics of Fruquintinib

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Fruquintinib (FRUZAQLATM) is a highly selective tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3). Two Phase 1, open‐label, single‐dose studies investigated the impact of hepatic or renal impairment on the pharmacokinetics and tolerability of fruquintinib.
Martha Gonzalez   +8 more
wiley   +1 more source

Utilization of Proteomic Measures for Early Detection of Drug Benefits and Adverse Effects

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Recognition of benefits and adverse effects of therapies in earlier clinical trial phases could improve the safety, efficiency, and cost of clinical trials. Using four clinical trials representing a diverse set of diseases and drug classes (EXSCEL: exenatide/GLP‐1 RA, SUGAR‐DM‐HF: empagliflozin/SGLT2i, PRADA: epirubicin/anthracycline, and ...
Jessica Chadwick   +17 more
wiley   +1 more source

Emotion and peer problems in autistic adolescents: The role of puberty, school adjustment and bullying

open access: yesJCPP Advances, EarlyView.
Abstract Background Emotion and peer problems tend to increase in autistic young people during adolescence. However, the extent to which endogenous (e.g., pubertal maturation) and exogenous (e.g., school adjustment, bullying) factors contribute to trajectories of emotion and peer problems in autistic young people is unclear. Methods Using data from the
Erin O. Dawe‐Lane   +3 more
wiley   +1 more source

Systematic review: Safety and efficacy of atomoxetine in children and adolescents with autism spectrum disorder

open access: yesJCPP Advances, EarlyView.
This systematic review aimed to assess the current evidence on the efficacy and safety of Atomoxetine in common clinical symptoms of autism spectrum disorder (ASD) for children and adolescents. With limited studies available, there is a need for more high‐power studies for the use of Atomoxetine in children and adolescents with autism spectrum disorder.
Nihit Gupta   +3 more
wiley   +1 more source

Characterization of alcohol-related seizures in withdrawal syndrome. [PDF]

open access: yesEpilepsia Open
Kádár BK   +4 more
europepmc   +1 more source

Mentalizing difficulties are transdiagnostic and explain links between mental health and neurodevelopmental symptoms and social adjustment in school‐aged children

open access: yesJCPP Advances, EarlyView.
Growing evidence suggests that difficulties reasoning about others' thoughts, feelings and desires (called ‘mentalizing’ or ‘theory of mind’) cut across many mental health and neurodevelopmental conditions but studies have yet to test this claim directly.
Rory T. Devine   +2 more
wiley   +1 more source

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