Results 101 to 110 of about 427,328 (297)

La vía Wnt/β-catenina disminuye la cantidad de osteoclastos en el hueso y favorece su apoptosis

Revista de Osteoporosis y Metabolismo Mineral, 2019
La activación de la señalización de Wnt/β-catenina en células del linaje osteoblástico conduce a un aumento en la masa ósea a través de un mecanismo dual: por una parte, aumentando la osteoblastogénesis, y por otra, disminuyendo la osteoclastogénesis. El
Martín-Millán M, Gónzalez-Martín MC, Ruíz P, Almeida M, Ros MA, González-Macías J   +5 more
doaj   +1 more source

Sequential Wnt Agonist then Antagonist Treatment Accelerates Tissue Repair and Minimizes Fibrosis [PDF]

, 2019
Tissue fibrosis compromises organ function and occurs as a potential long-term outcome in response to acute tissue injuries. Currently, lack of mechanistic understanding prevents effective prevention and treatment of the progression from acute injury to ...
Fu, Haiyan, Huang, Sui, Liu, Youhua, Tian, Xiao-Jun, Wang, Xiaojie, Xing, Jianhua, Zhang, Rong, Zhou, Dong   +7 more
core   +2 more sources

Convergence of Wnt signalling on the HNF4a-driven transcription in controlling liver zonation [PDF]

, 2009
BACKGROUND & AIMS: In each hepatocyte, the specific repertoire of gene expression is influenced by its exact location along the portocentrovenular axis of the hepatic lobule and provides a reason for the liver functions compartmentalization defined ...
Alonzi, T, Amicone, Laura, Cicchini, Carla, Colletti, M, Conigliaro, Alice, Pasquini, E, Santangelo, L, Tripodi, Marco   +7 more
core   +1 more source

Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

Advanced Functional Materials, EarlyView.
Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong   +9 more
wiley   +1 more source

Synaptic Wnt/GSK3β Signaling Hub in Autism [PDF]

, 2016
Indexación: ScopusHundreds of genes have been associated with autism spectrum disorders (ASDs) and the interaction of weak and de novo variants derive from distinct autistic phenotypes thus making up the "spectrum." The convergence of these variants in ...
Avila, M.E., Caracci, M.O., De Ferrari, G.V.   +2 more
core   +1 more source

Self‐Assembled Nanoclay Gel With Spheroid MSC‐Derived Exosome Mimetics to Integrate Demineralized Bone Matrix and Noggin‐Targeting miRNA for Synergistic Osteogenesis

Advanced Functional Materials, EarlyView.
We report a versatile nanoclay gel carrier platform that enhances the osteogenic efficacy of demineralized bone matrix (DBM) by integrating nanoclay‐based self‐assembly with cell‐derived exosome mimetics loaded with noggin‐targeting miR‐200c. This design amplifies BMP signaling, thereby promoting DBM‐mediated osteogenesis and offering a promising ...
Changlu Xu, Zhi Li, Minjee Kang, Ruoyu Sheng, Bing Han, Yiqing Chen, Tara Aghaloo, Min Lee   +7 more
wiley   +1 more source

EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. [PDF]

, 2019
Wnt signalling drives many processes in development, homeostasis and disease; however, the role and mechanism of individual ligand-receptor (Wnt-Frizzled (Fzd)) interactions in specific biological processes remain poorly understood. Wnt9a is specifically
Barahona, Rocio, Carrillo-Terrazas, Marvic, Drummond, Iain A, Gonzalez, David, Grainger, Stephanie, Houston, Jack, Kamei, Caramai N, Lonquich, Brianna, Nguyen, Nicole, Oon, Chet Huan, Richter, Jenna, Setayesh, Jordan, Traver, David, Willert, Karl, Wozniak, Jacob M   +14 more
core  

Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma. [PDF]

, 2015
Adamantinomatous craniopharyngiomas (ACPs) are the most common pituitary tumours in children. Although histologically benign, these are clinically aggressive tumours, difficult to manage and associated with poor quality of life for the patients.
Martinez-Barbera, JP
core   +1 more source

Chamber‐Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function

Advanced Healthcare Materials, EarlyView.
Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang, Myungji Kim, Hwanyong Choi, Jinseon Park, Minji Kim, Donghwan Kim, Bo Ram Lee, Jinah Jang   +7 more
wiley   +1 more source

Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? [PDF]

, 2017
BackgroundBlood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Boucher, Yves, Couraud, Pierre-Olivier, Mauborgne, Annie, Moreau, Nathan, Pohl, Michel, Romero, Ignacio A, Villanueva, Luis, Weksler, Babette B   +7 more
core   +4 more sources