Advanced Science, EarlyView.Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang +10 more
wiley +1 more source
Research Progress on Anti-Inflammatory Adipokine SFRP5-Mediated Lipid Metabolism and Its Potential Role in Neural Development. [PDF]
Immun Inflamm DisJia Q, Li Z, Yang T, Yang W, Chi W.
europepmc +1 more source
CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning
Advanced Science, EarlyView.CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang +11 more
wiley +1 more source
Engineered microtissue systems for identifying the roles of Wnt and YAP signaling in hepatoblast differentiation and organization. [PDF]
Mater Today BioGrenci B, Tsai A, Zobus K, Underhill GH.
europepmc +1 more source
Advanced Science, EarlyView.Both SVF and CD31+ SVF improve spontaneous osteoarthritis, but CD31+ enrichment refines the therapeutic profile rather than broadly enhancing all effects. More distinct benefits are observed in extracellular matrix remodeling, osteochondral integrity, and subchondral/trabecular bone preservation, supporting CD31+‐enriched SVF as a biologically enhanced
Sijia Zhou +16 more
wiley +1 more source
麻醉药布比卡因对卵巢癌干细胞样细胞中Wnt/β-catenin信号通路关键分子的影响
Zhongguo shiyan zhenduanxue目的观察麻醉药布比卡因对卵巢癌干细胞样细胞（Ovarian cancer stem-like cells,OCSLCs）中Wnt/β-连环蛋白（β-catenin）信号通路关键分子的影响。方法取SKOV3细胞系细胞进行体外培养，通过悬浮培养法获得OCSLCs，采用不同浓度（1 μM、10 μM、100 μM、1 mM）布比卡因处理OCSLCs，分为1 μM组、10 μM组、100 μM组及1 mM组，并设置空白对照组与安慰剂对照组（同等剂量浓度0.9%生理盐水处理），采用免疫组化法检测各组Wnt3a、β-
李梅, 赵建华, 赵石磊
doaj
Pharmacological Targeting of PI3K/Akt/mTOR and Wnt/GSK-3β Signaling in Oligodendrocyte Differentiation and Remyelination. [PDF]
CellsKim ME, Lee JS.
europepmc +1 more source
Optical Windows for Transcranial Brain Imaging in Living Mice: Skull Thinning, Clearing, and Beyond
Advanced Science, EarlyView.Longitudinal, noninvasive in vivo imaging is crucial for studying brain physiology. Advances in transcranial optical windows and multiphoton microscopy have improved imaging depth, but their performance often deteriorates over time. This work investigated various transcranial window approaches and found that skull regrowth limits image quality.
Yiming Fu +5 more
wiley +1 more source
Wnt/β-Catenin Pathway and Hydraulic Calcium Silicate-Based Cements: A Narrative Review. [PDF]
Dent J (Basel)Del Giudice C +6 more
europepmc +1 more source
Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature
Advanced Science, EarlyView.A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo +14 more
wiley +1 more source