Results 191 to 200 of about 459,861 (330)

Adverse Outcome Pathway 298: Increase in Reactive Oxygen Species Leading to Human Treatment-Resistant Gastric Cancer. [PDF]

Cancers (Basel)
Tanabe S, Quader S, Ono R, Cabral H, Perkins EJ.   +4 more
europepmc   +1 more source

Wnt Pathway in Bone Repair and Regeneration – What Do We Know So Far [PDF]

, 2019
Khosrow Siamak Houschyar, Christian Tapking, Mimi R. Borrelli, Daniel Popp, Dominik Duscher, Zeshaan N. Maan, Malcolm P. Chelliah, Jingtao Li, Kamran Harati, Christoph Wallner, Susanne Rein, Dominik Pförringer, Georg Reumuth, Gerrit Grieb, Sylvain Mouraret, Mehran Dadras, Johannes Maximilian Wagner, Jung‐Yul Cha, Frank Siemers, Marcus Lehnhardt, Björn Behr   +20 more
openalex   +1 more source

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

TWEAK regulates the functions of hair follicle stem cells via the Fn14‐Wnt/β‐catenin‐ CXCR4 signalling axis [PDF]

Xiaoyan Zou, Yaning Tian, Lingling Peng, Mai Luo, Yan Zhu, Zihan Xue, Xiaoming Liu, Yumin Xia   +7 more
openalex   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Chemotherapy-Treated Breast Cancer Cells Activate the WNT Signaling Pathway to Enter a Diapause-Like Early Persister State. [PDF]

Cancer Res
El Laithy Y, Abreu De Oliveira WA, Pabba A, Qualizza A, Cosemans G, Garcia-Diaz P, Richard F, Athanasouli P, Rios Luci C, De Wispelaere W, Mourao L, Hamer S, Moens S, De Jaime-Soguero A, Baietti MF, Hutten SJ, Jonkers J, Sammut SJ, Soenen S, Scheele CLGJ, Bruna A, Desmedt C, Annibali D, Lluis F.   +23 more
europepmc   +1 more source

Targeting of wnt signalling pathway by small bioactive molecules for the treatment of Alzheimer’s disease [PDF]

Ankumoni Dutta, Pallab Bhattacharya, Pavitra Chutia, Anupom Borah   +3 more
openalex   +1 more source

Wnt Signaling in the Regulation of Immune Cell and Cancer Therapeutics [PDF]

, 2019
Muhammad Haseeb, Rameez Hassan Pirzada, Qurat Ul Ain, Sangdun Choi   +3 more
openalex   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

RNA-Binding Proteins: Modulators of Canonical Wnt Signaling Pathway. [PDF]

Int J Mol Sci
Czap MS, Singh V, Spiegelman VS.
europepmc   +1 more source