Results 211 to 220 of about 427,328 (297)

Wnt Signaling Downregulation Mediates T Cell Apoptosis Following OKT3-Induced T Cell Activation in Preclinical Models. [PDF]

FASEB J
Choi M, Park D, Lee DH, Choi CH, Jo M, Jeong SY, Lim SY, Park D, Moon KS.   +8 more
europepmc   +1 more source

Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Advanced Science, EarlyView.
This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu, Yujia Zhou, Zihan Zhang, Rong Ma, Luyi Ruan, Liqing Miao, Boxin Zhang, Huihui Ji, Tianfeng Chen, Xueqiong Zhu   +9 more
wiley   +1 more source

High-throughput screening of small molecule Wnt/β-catenin activators for hair and nail growth. [PDF]

Commun Biol
Abudureyimu G, Jang HS, Shim J, Kim M, Kang M, Lee D.   +5 more
europepmc   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

The m6Am methyltransferase PCIF1 promotes osteogenic differentiation of mesenchymal stem cells through stabilization of Wnt-related transcripts. [PDF]

PLoS Biol
Song W, Su KJ, Pan Z, Zhang Z, Yin Q, Lin W, Liu L, Gong Y, Liang B, Cai Y, Li Q, Shen H, Deng HW, Yuan Q.   +13 more
europepmc   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

The class A repeats of LRP5 are required for normal development of bone, retinal vasculature and mammary gland in vivo

Disease Models & Mechanisms
Cassandra R. Diegel, Megan N. Michalski, John L. Ubels, Gabrielle Foxa Wiartalla, Cheng-Mao Lin, Zhendong A. Zhong, Mitchell J. McDonald, Nicole J. Ethen, Madison Brookshire, Zachary B. Madaj, Mingxuan Xia, Paul R. Gavine, David A. Antonetti, Bart O. Williams   +13 more
doaj   +1 more source

Persistent Wnt/β-catenin signaling disables soft palatogenesis and palatal osteogenesis by inducing mesenchymal condensation. [PDF]

Front Cell Dev Biol
Wang B, Xue J, Bian Y, Deng J, Liu B, Li N, Zhu L, Xiao J, Liu C, Liu H.   +9 more
europepmc   +1 more source

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

Astaxanthin Therapy in Women with Advanced Endometriosis: A Randomized Controlled Trial with Exploratory Analysis of Endometrial Wnt/β-Catenin Signaling

Rostami S, Aleyasin A, Nekoonam S, Shafie A, Saedi M, Amidi F.   +5 more
europepmc   +1 more source