Results 221 to 230 of about 313,995 (297)

Wnt/Notch Crosstalk Promotes Epithelial-Mesenchymal Transition During <i>Chlamydia trachomatis</i> Infection Under IFN-γ Treatment. [PDF]

Microorganisms
Yang Y, Fang C, Wu H, Chen L, Wen Y, Li Z.   +5 more
europepmc   +1 more source

ELF5‐Mediated Enhancer–Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland

Advanced Science, EarlyView.
In the study, we systematically investigate the epigenetic mechanisms underlying lactation traits in sheep by integrating transcriptomic, chromatin accessibility, histone modification, and functional analyses. We identify a super‐enhancer at the LALBA locus and demonstrate that enhancer E4 functions as its core regulatory element.
Xinmiao Wu, Jiqing Wang, Zhiyun Hao, Mingna Li, Huimin Zhen, Yuan Liu, Guoyong Zhao, Chunyan Ren, Xuelan Zhou, Haixiong Hu, Mingjie Li, Nan Shi   +11 more
wiley   +1 more source

DPP4 Substrate Supplementation Protects From WNT-Induced Lipid Depletion in Dermal Adipocytes. [PDF]

Exp Dermatol
Madhavan SR, Moore P, Ma Q, Atit RP.
europepmc   +1 more source

Bioengineered Stroma‐Camouflaged Nanovesicles Disrupt the IDO1/CD276 Immunosuppressive Circuit to Reinvigorate Antitumor Immunity

Advanced Science, EarlyView.
Bioengineered stroma‐camouflaged nanovesicles (AM@UIO‐BMS/DOX) convert the immunosuppressive tumor niche into an immunoresponsive milieu by disrupting the IDO1/CD276 circuit. Anti‐CD276 membrane camouflage guides tumor accumulation and deep penetration, enabling controlled co‐delivery of DOX and the IDO1 inhibitor BMS‐986205.
Ziqi Zhang, Jing Luo, Mengdi Zhang, Jingying Zhuang, Yating Zheng, Yang Zhang, Zhihong Huang, Xinhua Lin, Shuzhen Xu, Hong Yao, Gang Liu, Bing Chen   +11 more
wiley   +1 more source

Mechanisms of Neural Stem Cell Mediated Neurogenesis and Therapeutic Prospects Following Ischemic Stroke: A Review. [PDF]

Stem Cells Int
Wang S, Zhang J, Wang P, Ye P, Wu J, Shi L, Jiang X, Lu Y, Ge H, Yu A.   +9 more
europepmc   +1 more source

Engineering Spatially Localized Bioactive Microenvironments in Assembly Implants for Spatially Extended Bone Ingrowth

Advanced Science, EarlyView.
An assembly porous titanium/β‐TCP implant is developed to establish a spatially programmable osteogenic microenvironment for enhanced osseointegration. By decoupling mechanical support from bioactive ion release, localized ionic gradients generated from the β‐TCP module direct osteogenic activity and bone ingrowth toward the porous titanium framework ...
Heng Zhang, Jingjing Diao, Junhua Ke, Naru Zhao, Yudi Kuang, Yingjun Wang   +5 more
wiley   +1 more source

The class A repeats of LRP5 are required for normal development of bone, retinal vasculature and mammary gland in vivo

Disease Models & Mechanisms
Cassandra R. Diegel, Megan N. Michalski, John L. Ubels, Gabrielle Foxa Wiartalla, Cheng-Mao Lin, Zhendong A. Zhong, Mitchell J. McDonald, Nicole J. Ethen, Madison Brookshire, Zachary B. Madaj, Mingxuan Xia, Paul R. Gavine, David A. Antonetti, Bart O. Williams   +13 more
doaj   +1 more source

Tumor‐Intrinsic HEXB Drives Endothelial‐To‐Mesenchymal Transition and Confers Resistance to Anti‐Angiogenic Therapy in Glioblastoma

Advanced Science, EarlyView.
This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu, Xin Chen, Tao Sun, Jianqi Wu, Haixu Yan, Xing Liu, Hongda Lin, Xiangyu Wang, Ziao Xiao, Yang Xu, Qiang Fu, Peng Cheng, Wen Cheng, Anhua Wu   +13 more
wiley   +1 more source

Sharp cell type boundaries emerge from coordinated morphogen signaling. [PDF]

Genes Dev
Li R, Jiang Y, Platt S, Xin T, Lukkad S, Van S, Peterson KA, Driskell R, Zhu J, Lam H, Barber EL, Wang DH, Lim CH, Taketo MM, Kluger Y, Myung P.   +15 more
europepmc   +1 more source