Results 111 to 120 of about 271,086 (305)

Modelling and analysis of biochemical signalling pathway cross-talk [PDF]

, 2010
Signalling pathways are abstractions that help life scientists structure the coordination of cellular activity. Cross-talk between pathways accounts for many of the complex behaviours exhibited by signalling pathways and is often critical in producing ...
Emanuela Merelli, Muffy Calder, Paola Quaglia, Robin Donaldson   +3 more
core   +5 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours [PDF]

, 2014
Primary liver tumours have a high incidence and mortality. The most important forms are hepatocellular carcinoma and intrahepatic cholangiocarcinoma, both can occur together in the mixed phenotype hepatocellular-cholangiocarcinoma. Liver progenitor cells
Bogaerts, Eliene, Heindryckx, Femke, Van Grunsven, Leo A, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul   +4 more
core   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer

Journal of Translational Medicine
Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators, including proteins, miRNAs, lncRNAs, and circRNAs, have been found to promote ...
Zixu Zhang, David Westover, Zhantong Tang, Yue Liu, Jinghan Sun, Yunxi Sun, Runqing Zhang, Xingyue Wang, Shihui Zhou, Nigaerayi Hesilaiti, Qi Xia, Zhenfang Du   +11 more
doaj   +1 more source

Dishevelled Paralogs in Vertebrate Development: Redundant or Distinct?

Frontiers in Cell and Developmental Biology, 2017
Dishevelled (DVL) proteins are highly conserved in the animal kingdom and are important key players in β-Catenin-dependent and -independent Wnt signaling pathways. Vertebrate genomes typically comprise three DVL genes, DVL1, DVL2, and DVL3.
Marc Gentzel, Alexandra Schambony
doaj   +1 more source

Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

Advanced Functional Materials, EarlyView.
Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong   +9 more
wiley   +1 more source

Mathematical and Statistical Techniques for Systems Medicine: The Wnt Signaling Pathway as a Case Study

, 2015
The last decade has seen an explosion in models that describe phenomena in systems medicine. Such models are especially useful for studying signaling pathways, such as the Wnt pathway.
A Gelman, A Saltelli, AC Babtie, AG Fletcher, AL MacLean, AL MacLean, AR Hernández, B Alberts, B Carlin, B Lloyd-Lewis, BR Henderson, CW Gardiner, CW Tan, CW Tan, CY Logan, D Brewer, D Cox, D Kim, E Feliu, E Lee, ER Barry, F Cong, G Craciun, G Craciun, G Craciun, GR Mirams, H Clevers, H Kitano, HA Harrington, I Ramis-Conde, IMM Leeuwen van, J Franca-Koh, J Heuberger, J Jost, J Liepe, J Liepe, J Neumann von, J Stark, J Stelling, J. Kevorkian, K Itoh, KH Cho, L Goentoro, L Vermeulen, M Basan, M Beguerisse-Díaz, M Feinberg, M Feinberg, M Kuhl, M Secrier, M Sunnåker, N Blüthgen, N Gershenfeld, N Gilbert, N Wiechens, O Ratmann, P Buske, P Glendinning, P Kirk, P Polakis, PJ Murray, PJ Murray, R Habas, R Krüger, RN Gutenkunst, S Wolfram, T Reya, T Toni, VSW Li, X Varelas, Y Kogan, Y Schmitz, Y Schmitz, Y Zhou   +73 more
core   +1 more source

Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. [PDF]

, 2016
1,25 dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, and calcium regulate epidermal differentiation. 1,25(OH)2D exerts its effects through the vitamin D receptor (VDR), a transcription factor in the nuclear hormone receptor family ...
Bikle, Daniel D, Jiang, Yan, Nguyen, Thai, Oda, Yuko, Tu, Chia-Ling   +4 more
core   +2 more sources

Self‐Assembled Nanoclay Gel With Spheroid MSC‐Derived Exosome Mimetics to Integrate Demineralized Bone Matrix and Noggin‐Targeting miRNA for Synergistic Osteogenesis

Advanced Functional Materials, EarlyView.
We report a versatile nanoclay gel carrier platform that enhances the osteogenic efficacy of demineralized bone matrix (DBM) by integrating nanoclay‐based self‐assembly with cell‐derived exosome mimetics loaded with noggin‐targeting miR‐200c. This design amplifies BMP signaling, thereby promoting DBM‐mediated osteogenesis and offering a promising ...
Changlu Xu, Zhi Li, Minjee Kang, Ruoyu Sheng, Bing Han, Yiqing Chen, Tara Aghaloo, Min Lee   +7 more
wiley   +1 more source