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Convergent mechanisms in Wnt and Hedgehog signaling. [PDF]

Sci Signal
Myers BR, Zalatan JG, Virshup DM.
europepmc   +1 more source

Helping Wingless Take Flight: How WNT Proteins Are Secreted

Nature Reviews Molecular Cell Biology, 2007
How functional WNT proteins are made and how their secretion is regulated is becoming a focal point for the WNT-signalling field. Recently, lipoprotein particles, WNT lipid modifications, the conserved transmembrane protein Wntless (WLS; also known as ...
George Hausmann, Konrad Basler, Carla Bänziger   +2 more
exaly   +2 more sources

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Fatty acylation of Wnt proteins

Nature Chemical Biology, 2016
Wnt proteins are critical regulators of signaling networks during embryonic development and in adult tissue homeostasis. The generation of active Wnt proteins requires their regulated secretion into the extracellular space. Once secreted, Wnts signal through the cell surface via receptor binding on Wnt-receiving cells, a mechanism that is prevalent in ...
Aaron H, Nile, Rami N, Hannoush
openaire   +2 more sources