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Fatty acylation of Wnt proteins
Nature Chemical Biology, 2016Wnt proteins are critical regulators of signaling networks during embryonic development and in adult tissue homeostasis. The generation of active Wnt proteins requires their regulated secretion into the extracellular space. Once secreted, Wnts signal through the cell surface via receptor binding on Wnt-receiving cells, a mechanism that is prevalent in ...
Aaron H, Nile, Rami N, Hannoush
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The role of Wnt proteins in arthritis
Nature Clinical Practice Rheumatology, 2008Wnt proteins regulate organ development, tumorigenesis and bone homeostasis, among other functions. The binding of Wnt proteins to plasma membrane receptors on mesenchymal cells induces the differentiation of these cells into the osteoblast lineage and thereby supports bone formation.
Georg, Schett +2 more
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WNT-mediated relocalization of dishevelled proteins
In Vitro Cellular & Developmental Biology - Animal, 1996The Wnt family of proto-oncogenes encodes secreted signaling proteins that are required for mouse development. The Drosophila Wnt homolog, the wingless (Wg) segment polarity gene, mediates a signal transduction pathway in which the downstream elements appear to be conserved through evolution.
S A, Steitz, M, Tsang, D J, Sussman
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Multiplicity of the interactions of Wnt proteins and their receptors
Cellular Signalling, 2007Wnts are secreted proteins that are essential for a wide array of developmental and physiological processes. They signal across the plasma membranes by interacting with serpentine receptors of the Frizzled (Fz) family and members of the low-density-lipoprotein receptor-related protein (LRP) family.
Akira, Kikuchi +2 more
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Active Wnt proteins are secreted on exosomes
Nature Cell Biology, 2012Wnt signalling has important roles during development and in many diseases. As morphogens, hydrophobic Wnt proteins exert their function over a distance to induce patterning and cell differentiation decisions. Recent studies have identified several factors that are required for the secretion of Wnt proteins; however, how Wnts travel in the ...
Julia Christina, Gross +3 more
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Wnt Proteins Promote Bone Regeneration
Science Translational Medicine, 2010A liposome-encased ligand for the Wnt signaling pathway can accelerate bone regeneration after injury.
Minear, Steven +7 more
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Acta Physiologica, 2011
AbstractThe Wnt family of signalling proteins has essential functions in development and adult tissue homoeostasis throughout the animal kingdom. Although signalling cascades triggered by Wnt proteins have been extensively studied, much remains to be learned about how Wnts are produced and secreted. Over the past few years, it has become clear that the
Harterink, M., Korswagen, H.C.
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AbstractThe Wnt family of signalling proteins has essential functions in development and adult tissue homoeostasis throughout the animal kingdom. Although signalling cascades triggered by Wnt proteins have been extensively studied, much remains to be learned about how Wnts are produced and secreted. Over the past few years, it has become clear that the
Harterink, M., Korswagen, H.C.
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The Informational Content of Gradients of Wnt Proteins
Science's STKE, 2000This perspective tackles the issues facing developmental biologists and cell biologists regarding how the molecular mechanisms for specifying cell fate are defined. This Perspective focuses on members of the Wnt family. The author proposes that Wnt proteins may act as stabilizing signals for earlier inductive events in certain systems, for
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Secretion and extracellular space travel of Wnt proteins
Current Opinion in Genetics & Development, 2013Wnt signaling pathways control many processes during development, stem cell maintenance and homeostasis, and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Wnts are hydrophobic proteins, however, quite paradoxically, they can travel over distances to induce cell-type specific responses ...
Julia Christina, Gross, Michael, Boutros
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NMR structure of the Wnt modulator protein Sclerostin
Biochemical and Biophysical Research Communications, 2009Sclerostin has been identified as a negative regulator of bone growth. Initially it was considered that Sclerostin performs its regulatory function via acting as a modulator of bone morphogenetic proteins (BMPs) similar to known examples such as Noggin, Chordin, and members of the DAN family.
Stella E, Weidauer +5 more
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