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WNT-mediated relocalization of dishevelled proteins
In Vitro Cellular & Developmental Biology - Animal, 1996The Wnt family of proto-oncogenes encodes secreted signaling proteins that are required for mouse development. The Drosophila Wnt homolog, the wingless (Wg) segment polarity gene, mediates a signal transduction pathway in which the downstream elements appear to be conserved through evolution.
S A, Steitz, M, Tsang, D J, Sussman
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Wnt Proteins Promote Bone Regeneration
Science Translational Medicine, 2010A liposome-encased ligand for the Wnt signaling pathway can accelerate bone regeneration after injury.
Minear, Steven +7 more
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The Informational Content of Gradients of Wnt Proteins
Science's STKE, 2000This perspective tackles the issues facing developmental biologists and cell biologists regarding how the molecular mechanisms for specifying cell fate are defined. This Perspective focuses on members of the Wnt family. The author proposes that Wnt proteins may act as stabilizing signals for earlier inductive events in certain systems, for
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Acta Physiologica, 2011
AbstractThe Wnt family of signalling proteins has essential functions in development and adult tissue homoeostasis throughout the animal kingdom. Although signalling cascades triggered by Wnt proteins have been extensively studied, much remains to be learned about how Wnts are produced and secreted. Over the past few years, it has become clear that the
Harterink, M., Korswagen, H.C.
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AbstractThe Wnt family of signalling proteins has essential functions in development and adult tissue homoeostasis throughout the animal kingdom. Although signalling cascades triggered by Wnt proteins have been extensively studied, much remains to be learned about how Wnts are produced and secreted. Over the past few years, it has become clear that the
Harterink, M., Korswagen, H.C.
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Secretion and extracellular space travel of Wnt proteins
Current Opinion in Genetics & Development, 2013Wnt signaling pathways control many processes during development, stem cell maintenance and homeostasis, and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Wnts are hydrophobic proteins, however, quite paradoxically, they can travel over distances to induce cell-type specific responses ...
Julia Christina, Gross, Michael, Boutros
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Isolation and Application of Bioactive Wnt Proteins
2008Wnt proteins and their signaling cascades are involved in a wide variety of developmental processes, and deregulation of this pathway is frequently associated with tumorigenesis. Unlike many other growth factors, Wnts long eluded biochemical purification, in large part because of their hydrophobic nature, which is imparted by one or more lipid ...
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Wnt signalling: the case of the ‘missing’ G-protein
Biochemical Journal, 2011Wnt signalling remains a hot topic for cell signalling sleuthhounds. The trail of signalling downstream of the seven-transmembrane segment Frizzleds, which bind Wnt ligands, is replete of clues [e.g. LPR5/6 (lipoprotein receptor-related protein 5/6), G-proteins or Dishevelled] and yet remains the ‘final problem’.
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Helping Wingless take flight: how WNT proteins are secreted
Nature Reviews Molecular Cell Biology, 2007George Hausmann +2 more
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