Results 211 to 220 of about 271,086 (305)

Combined impact of ROR2 and its ligands on the pathogenesis and prognosis of idiopathic pulmonary fibrosis. [PDF]

Sarcoidosis Vasc Diffuse Lung Dis
Park SL, Lee JU, Kim MK, Seo E, Kim MS, Hwang HG, Kim JH, Chang HS, Park CS.   +8 more
europepmc   +1 more source

Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays

Advanced Science, EarlyView.
ABSTRACT Evaluating the potential toxicity of pharmaceuticals and biomaterials to ectodermal epithelia, such as the oral mucosa and skin, is indispensable in pre‐clinical assessments. However, this remains a challenge primarily owing to the lack of physiologically relevant and accurate screening models.
Yiming Chen, Yuman Li, Chenyu Deng, Leran Li, Zhewen Hu, Boon Chin Heng, Yuting Niu, Shiyu Sun, Min Gao, Xiaopei Chi, Ying He, Mingming Xu, Ying Huang, Xuliang Deng   +13 more
wiley   +1 more source

Dose-resolved control of somatic reprogramming by Rora. [PDF]

Stem Cell Reports
Wang H, Li Y, Yin C, Zhang Z, Wang Y, Li Y, Li C, Lin R, Zhang X, Guo J, Luo R, Li S, Zhang L, Zhuang Y, Xu A, Wan J, Xiao L, Chen B, Yu S, Kumar M, Liu J.   +20 more
europepmc   +1 more source

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

A Double-Negative Prostate Cancer Subtype Is Vulnerable to SWI/SNF-Targeting Degrader Molecules. [PDF]

Cancer Res
Thienger P, Paassen I, Yao X, Rubin PD, Lehner M, Lillis N, Benjak A, Shah SR, Leung AK, de Brot S, Naveed A, Daniel B, Shi M, Tremblay J, Triscott J, Cassanmagnago GA, Bolis M, Mela L, Beltran H, Chen Y, Piscuoglio S, Yu H, Ng CKY, Quigley DA, Yauch RL, Rubin MA.   +25 more
europepmc   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

The role of extracellular vesicles in the context of (inter-)cellular communication contributing to adipose tissue dysfunction in lipedema. [PDF]

Front Cell Dev Biol
Morawitz KH, Gross JC.
europepmc   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Montelukast attenuates diclofenac sodium-induced cardiotoxicity in male rats via targeting Wnt/β-catenin pathway. [PDF]

Sci Rep
Alsanea S, Albuhayri S, Alkharashi L, Ali N, AlAsmari AF, Arafah M, Hasan I, Ali R, Attia H.   +8 more
europepmc   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, EarlyView.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source