Results 201 to 210 of about 1,874,468 (294)

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Piezo1 mediates stretch-induced Wnt/β-catenin signaling and extracellular matrix remodeling in aging asthmatic airway smooth muscle. [PDF]

Am J Respir Cell Mol Biol
Borkar NA, Pfeffer-Kleemann DA, Hamrick SK, Koloko Ngassie ML, Thompson MA, Pabelick CM, Prakash YS.   +6 more
europepmc   +1 more source

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source

The Role of Viral Pathogens in the Promotion of Epithelial-Mesenchymal Transition and Neoplastic Cell Invasion. [PDF]

Viruses
Tugizov S.
europepmc   +1 more source

ELF5‐Mediated Enhancer–Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland

Advanced Science, EarlyView.
In the study, we systematically investigate the epigenetic mechanisms underlying lactation traits in sheep by integrating transcriptomic, chromatin accessibility, histone modification, and functional analyses. We identify a super‐enhancer at the LALBA locus and demonstrate that enhancer E4 functions as its core regulatory element.
Xinmiao Wu, Jiqing Wang, Zhiyun Hao, Mingna Li, Huimin Zhen, Yuan Liu, Guoyong Zhao, Chunyan Ren, Xuelan Zhou, Haixiong Hu, Mingjie Li, Nan Shi   +11 more
wiley   +1 more source

SOX2 Inhibits Cuproptosis to Affect Cisplatin Resistance in Non-Small Cell Lung Cancer by Activating the Wnt/ATP7B Signaling Pathway. [PDF]

Kaohsiung J Med Sci
Chen K, He FM, Huang YH, Fang T, Zheng YP, Cai JF.   +5 more
europepmc   +1 more source

Bioengineered Stroma‐Camouflaged Nanovesicles Disrupt the IDO1/CD276 Immunosuppressive Circuit to Reinvigorate Antitumor Immunity

Advanced Science, EarlyView.
Bioengineered stroma‐camouflaged nanovesicles (AM@UIO‐BMS/DOX) convert the immunosuppressive tumor niche into an immunoresponsive milieu by disrupting the IDO1/CD276 circuit. Anti‐CD276 membrane camouflage guides tumor accumulation and deep penetration, enabling controlled co‐delivery of DOX and the IDO1 inhibitor BMS‐986205.
Ziqi Zhang, Jing Luo, Mengdi Zhang, Jingying Zhuang, Yating Zheng, Yang Zhang, Zhihong Huang, Xinhua Lin, Shuzhen Xu, Hong Yao, Gang Liu, Bing Chen   +11 more
wiley   +1 more source

Osteoporosis and Alzheimer's Disease: The Role of Sclerostin. [PDF]

Curr Osteoporos Rep
Gagiano L, Chen Z, Blakeney WG, Jones C, Mastaglia F, Zheng M, Yuan J.   +6 more
europepmc   +1 more source

Engineering Spatially Localized Bioactive Microenvironments in Assembly Implants for Spatially Extended Bone Ingrowth

Advanced Science, EarlyView.
An assembly porous titanium/β‐TCP implant is developed to establish a spatially programmable osteogenic microenvironment for enhanced osseointegration. By decoupling mechanical support from bioactive ion release, localized ionic gradients generated from the β‐TCP module direct osteogenic activity and bone ingrowth toward the porous titanium framework ...
Heng Zhang, Jingjing Diao, Junhua Ke, Naru Zhao, Yudi Kuang, Yingjun Wang   +5 more
wiley   +1 more source

Tumor‐Intrinsic HEXB Drives Endothelial‐To‐Mesenchymal Transition and Confers Resistance to Anti‐Angiogenic Therapy in Glioblastoma

Advanced Science, EarlyView.
This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu, Xin Chen, Tao Sun, Jianqi Wu, Haixu Yan, Xing Liu, Hongda Lin, Xiangyu Wang, Ziao Xiao, Yang Xu, Qiang Fu, Peng Cheng, Wen Cheng, Anhua Wu   +13 more
wiley   +1 more source