Results 271 to 280 of about 176,136 (293)
Some of the next articles are maybe not open access.
Fatty acylation of Wnt proteins
Nature Chemical Biology, 2016Wnt proteins are critical regulators of signaling networks during embryonic development and in adult tissue homeostasis. The generation of active Wnt proteins requires their regulated secretion into the extracellular space. Once secreted, Wnts signal through the cell surface via receptor binding on Wnt-receiving cells, a mechanism that is prevalent in ...
Aaron H, Nile, Rami N, Hannoush
openaire +2 more sources
Wnt Proteins Promote Bone Regeneration
Science Translational Medicine, 2010A liposome-encased ligand for the Wnt signaling pathway can accelerate bone regeneration after injury.
Minear, Steven +7 more
openaire +3 more sources
WNT-mediated relocalization of dishevelled proteins
In Vitro Cellular & Developmental Biology - Animal, 1996The Wnt family of proto-oncogenes encodes secreted signaling proteins that are required for mouse development. The Drosophila Wnt homolog, the wingless (Wg) segment polarity gene, mediates a signal transduction pathway in which the downstream elements appear to be conserved through evolution.
S A, Steitz, M, Tsang, D J, Sussman
openaire +2 more sources
Wnt Proteins in Mammary Development and Cancer
Journal of Mammary Gland Biology and Neoplasia, 2004Secreted proteins of the Wnt family play widespread roles in the regulation of embryonic development, and aberrant activation of the canonical Wnt/beta-catenin pathway is one of the most frequent signaling abnormalities known in human cancer. While the consequences of Wnt signaling in development are diverse at the cellular level, they are often ...
Brennan, Keith R., Brown, Anthony M C
openaire +3 more sources
Active Wnt proteins are secreted on exosomes
Nature Cell Biology, 2012Wnt signalling has important roles during development and in many diseases. As morphogens, hydrophobic Wnt proteins exert their function over a distance to induce patterning and cell differentiation decisions. Recent studies have identified several factors that are required for the secretion of Wnt proteins; however, how Wnts travel in the ...
Julia Christina, Gross +3 more
openaire +2 more sources
The role of Wnt proteins in arthritis
Nature Clinical Practice Rheumatology, 2008Wnt proteins regulate organ development, tumorigenesis and bone homeostasis, among other functions. The binding of Wnt proteins to plasma membrane receptors on mesenchymal cells induces the differentiation of these cells into the osteoblast lineage and thereby supports bone formation.
Georg, Schett +2 more
openaire +2 more sources
Journal of Cell Science, 1999
ABSTRACT The Wnt gene family encodes proteins that serve key roles in differentiation and development. Wnt proteins interact with seven transmembrane receptors of the Frizzled family and activate a signaling pathway leading to the nucleus. A primary biochemical effect of Wnt-1 signaling is the stabilization of cytoplasmic β-catenin which,
S, Dennis +4 more
openaire +2 more sources
ABSTRACT The Wnt gene family encodes proteins that serve key roles in differentiation and development. Wnt proteins interact with seven transmembrane receptors of the Frizzled family and activate a signaling pathway leading to the nucleus. A primary biochemical effect of Wnt-1 signaling is the stabilization of cytoplasmic β-catenin which,
S, Dennis +4 more
openaire +2 more sources
Wnt-frizzled signaling to G-protein-coupled effectors
Cellular and Molecular Life Sciences (CMLS), 2004Wnt proteins signal via cell surface receptors termed Frizzleds. Frizzleds display many properties characteristic of members of the superfamily of G-protein-coupled receptors, including heptihelical hydropathy plots; an exofacial N-terminal region that is glycosylated; a cytoplasmic C-terminal region that includes canonical motifs for phosphorylation ...
H-Y, Wang, C C, Malbon
openaire +2 more sources
NMR structure of the Wnt modulator protein Sclerostin
Biochemical and Biophysical Research Communications, 2009Sclerostin has been identified as a negative regulator of bone growth. Initially it was considered that Sclerostin performs its regulatory function via acting as a modulator of bone morphogenetic proteins (BMPs) similar to known examples such as Noggin, Chordin, and members of the DAN family.
Stella E, Weidauer +5 more
openaire +2 more sources
Secretion and extracellular space travel of Wnt proteins
Current Opinion in Genetics & Development, 2013Wnt signaling pathways control many processes during development, stem cell maintenance and homeostasis, and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Wnts are hydrophobic proteins, however, quite paradoxically, they can travel over distances to induce cell-type specific responses ...
Julia Christina, Gross, Michael, Boutros
openaire +2 more sources