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AMBP gene activation promotes cholangiocarcinoma progression through the WNT/β-catenin signaling pathway: Regulatory effect of polysaccharides from Auricularia auricula-judae. [PDF]

Medicine (Baltimore)
Yang C, Liu Y, Zhang Y, Yang Y, Wu X, Wang Y, Sun F, Zhao Z.   +7 more
europepmc   +1 more source

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LDL-receptor-related proteins in Wnt signal transduction

Nature, 2000
The Wnt family of secreted signalling molecules are essential in embryo development and tumour formation. The Frizzled (Fz) family of serpentine receptors function as Wnt receptors, but how Fz proteins transduce signalling is not understood. In Drosophila, arrow phenocopies the wingless (DWnt-1) phenotype, and encodes a transmembrane protein that is ...
K, Tamai, M, Semenov, Y, Kato, R, Spokony, C, Liu, Y, Katsuyama, F, Hess, J P, Saint-Jeannet, X, He   +8 more
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Fatty acylation of Wnt proteins

Nature Chemical Biology, 2016
Wnt proteins are critical regulators of signaling networks during embryonic development and in adult tissue homeostasis. The generation of active Wnt proteins requires their regulated secretion into the extracellular space. Once secreted, Wnts signal through the cell surface via receptor binding on Wnt-receiving cells, a mechanism that is prevalent in ...
Aaron H, Nile, Rami N, Hannoush
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Wnt Proteins Promote Bone Regeneration

Science Translational Medicine, 2010
A liposome-encased ligand for the Wnt signaling pathway can accelerate bone regeneration after injury.
Minear, Steven, Leucht, Philipp, Jiang, Jie, Liu, Bo, Zeng, Yi Arial, Fuerer, Christophe, Nusse, Roel, Helms, Jill A.   +7 more
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WNT-mediated relocalization of dishevelled proteins

In Vitro Cellular & Developmental Biology - Animal, 1996
The Wnt family of proto-oncogenes encodes secreted signaling proteins that are required for mouse development. The Drosophila Wnt homolog, the wingless (Wg) segment polarity gene, mediates a signal transduction pathway in which the downstream elements appear to be conserved through evolution.
S A, Steitz, M, Tsang, D J, Sussman
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Wnt Proteins in Mammary Development and Cancer

Journal of Mammary Gland Biology and Neoplasia, 2004
Secreted proteins of the Wnt family play widespread roles in the regulation of embryonic development, and aberrant activation of the canonical Wnt/beta-catenin pathway is one of the most frequent signaling abnormalities known in human cancer. While the consequences of Wnt signaling in development are diverse at the cellular level, they are often ...
Brennan, Keith R., Brown, Anthony M C
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Active Wnt proteins are secreted on exosomes

Nature Cell Biology, 2012
Wnt signalling has important roles during development and in many diseases. As morphogens, hydrophobic Wnt proteins exert their function over a distance to induce patterning and cell differentiation decisions. Recent studies have identified several factors that are required for the secretion of Wnt proteins; however, how Wnts travel in the ...
Julia Christina, Gross, Varun, Chaudhary, Kerstin, Bartscherer, Michael, Boutros   +3 more
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The role of Wnt proteins in arthritis

Nature Clinical Practice Rheumatology, 2008
Wnt proteins regulate organ development, tumorigenesis and bone homeostasis, among other functions. The binding of Wnt proteins to plasma membrane receptors on mesenchymal cells induces the differentiation of these cells into the osteoblast lineage and thereby supports bone formation.
Georg, Schett, Jochen, Zwerina, Jean-Pierre, David   +2 more
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