Results 271 to 280 of about 271,086 (305)
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Journal of Cell Science, 1999
ABSTRACT The Wnt gene family encodes proteins that serve key roles in differentiation and development. Wnt proteins interact with seven transmembrane receptors of the Frizzled family and activate a signaling pathway leading to the nucleus. A primary biochemical effect of Wnt-1 signaling is the stabilization of cytoplasmic β-catenin which,
S, Dennis +4 more
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ABSTRACT The Wnt gene family encodes proteins that serve key roles in differentiation and development. Wnt proteins interact with seven transmembrane receptors of the Frizzled family and activate a signaling pathway leading to the nucleus. A primary biochemical effect of Wnt-1 signaling is the stabilization of cytoplasmic β-catenin which,
S, Dennis +4 more
openaire +2 more sources
Wnt-frizzled signaling to G-protein-coupled effectors
Cellular and Molecular Life Sciences (CMLS), 2004Wnt proteins signal via cell surface receptors termed Frizzleds. Frizzleds display many properties characteristic of members of the superfamily of G-protein-coupled receptors, including heptihelical hydropathy plots; an exofacial N-terminal region that is glycosylated; a cytoplasmic C-terminal region that includes canonical motifs for phosphorylation ...
H-Y, Wang, C C, Malbon
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NMR structure of the Wnt modulator protein Sclerostin
Biochemical and Biophysical Research Communications, 2009Sclerostin has been identified as a negative regulator of bone growth. Initially it was considered that Sclerostin performs its regulatory function via acting as a modulator of bone morphogenetic proteins (BMPs) similar to known examples such as Noggin, Chordin, and members of the DAN family.
Stella E, Weidauer +5 more
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Secretion and extracellular space travel of Wnt proteins
Current Opinion in Genetics & Development, 2013Wnt signaling pathways control many processes during development, stem cell maintenance and homeostasis, and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Wnts are hydrophobic proteins, however, quite paradoxically, they can travel over distances to induce cell-type specific responses ...
Julia Christina, Gross, Michael, Boutros
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The Informational Content of Gradients of Wnt Proteins
Science's STKE, 2000This perspective tackles the issues facing developmental biologists and cell biologists regarding how the molecular mechanisms for specifying cell fate are defined. This Perspective focuses on members of the Wnt family. The author proposes that Wnt proteins may act as stabilizing signals for earlier inductive events in certain systems, for
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Isolation and Application of Bioactive Wnt Proteins
2008Wnt proteins and their signaling cascades are involved in a wide variety of developmental processes, and deregulation of this pathway is frequently associated with tumorigenesis. Unlike many other growth factors, Wnts long eluded biochemical purification, in large part because of their hydrophobic nature, which is imparted by one or more lipid ...
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Wnt Proteins in Mineralized Tissue Development and Homeostasis
Connective Tissue Research, 2011The past decade has seen rapid advancement in the dissection of the molecular events and players in the development and homeostasis of mineralized tissues, that is, teeth and bones. Much of this is due to research efforts toward the regeneration of these organs and also to develop treatments for pathologies of bone, especially osteoporosis.
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Mutations and mechanisms of WNT pathway tumour suppressors in cancer
Nature Reviews Cancer, 2020Jeroen M Bugter +2 more
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