Results 61 to 70 of about 259,205 (374)

Anti-inflammatory activity of Wnt signaling in enteric nervous system: in vitro preliminary evidences in rat primary cultures [PDF]

, 2015
Background: In the last years, Wnt signaling was demonstrated to regulate inflammatory processes. In particular, an increased expression of Wnts and Frizzled receptors was reported in inflammatory bowel disease (IBD) and ulcerative colitis to exert both ...
Anne, Schuster, Bertalot, Thomas, Conconi, MARIA TERESA, DI LIDDO, Rosa, Ilenia, Zanusso, Karl Herbert, Sch\ue4fer, Schrenk, Sandra, Tasso, Alessia   +7 more
core   +2 more sources

HDAC1 regulates inflammation and osteogenic differentiation of ankylosing spondylitis fibroblasts through the Wnt-Smad signaling pathway

Journal of Orthopaedic Surgery and Research, 2022
Ankylosing spondylitis (AS) is a refractory autoimmune disease, whose typical pathology is the development of inflammation to ossification and ankylosis.
Yong Zeng, Rui He, Yong Liu, Ting Luo, Qing Li, Yu He, Miao Fang, Taiping Wang   +7 more
doaj   +1 more source

Exact short-time height distribution in 1D KPZ equation with Brownian initial condition [PDF]

Phys. Rev. E 96, 020102 (2017), 2017
The early time regime of the Kardar-Parisi-Zhang (KPZ) equation in $1+1$ dimension, starting from a Brownian initial condition with a drift $w$, is studied using the exact Fredholm determinant representation. For large drift we recover the exact results for the droplet initial condition, whereas a vanishingly small drift describes the stationary KPZ ...
arxiv   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled. [PDF]

, 2015
Frizzled is the earliest discovered glycosylated Wnt protein receptor and is critical for the initiation of Wnt signaling. Antagonizing Frizzled is effective in inhibiting the growth of multiple tumor types.
Baday, Yiressy C, Bao, Ju, Guibao, Cristina, Lee, Ho-Jin, Li, Lin, Miller, Ami, Wu, Dianqing, Wu, Jibo, Zhang, Chi, Zheng, Jie J   +9 more
core   +2 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Soluble Frizzled-related proteins promote exosome-mediated Wnt re-secretion

Communications Biology
Wnt proteins are thought to be transported in several ways in the extracellular space. For instance, they are known to be carried by exosomes and by Wnt-carrier proteins, such as sFRP proteins.
Thi Hong Nguyen Tran, Ritsuko Takada, Elena Krayukhina, Takahiro Maruno, Yusuke Mii, Susumu Uchiyama, Shinji Takada   +6 more
doaj   +1 more source

Alternative splicing of the Wnt trafficking protein, Wntless and its effects on protein-protein interactions

BMC Molecular and Cell Biology, 2019
Background Wntless (Wls) is a protein that regulates secretion of Wnt signaling molecules from Wnt-producing cells. Wnt signaling is known to be critical for several developmental and homeostatic processes.
Jessica Petko, Mathura Thileepan, Molly Sargen, Victor Canfield, Robert Levenson   +4 more
doaj   +1 more source

The Wnt/β-catenin signalling pathway in Haematological Neoplasms

Biomarker Research, 2022
Leukaemia and lymphoma are common malignancies. The Wnt pathway is a complex network of proteins regulating cell proliferation and differentiation, as well as cancer development, and is divided into the Wnt/β-catenin signalling pathway (the canonical Wnt
Siwei Yu, Ruyue Han, Runliang Gan
doaj   +1 more source

WISP genes are members of the connective tissue growth factor family that are up-regulated in Wnt-1-transformed cells and aberrantly expressed in human colon tumors [PDF]

, 1998
Wnt family members are critical to many developmental processes, and components of the Wnt signaling pathway have been linked to tumorigenesis in familial and sporadic colon carcinomas.
Botstein, D., Brush, J., Cohen, R.L., Deuel, B., Finley, G.G., Goddard, A.D., Gurney, A.L., Hillan, K.J., Lawrence, D.A., Lee, J., Levine, A.J., Lew, M., Melhem, M.F., Pennica, D., Quirke, P., Roy, M.A., Swanson, T.A., Taneyhill, L.A., Watanabe, C., Welsh, J.W.   +19 more
core