Results 91 to 100 of about 1,026,340 (233)

Wnt signaling pathways in urological cancers: past decades and still growing

Molecular Cancer, 2012
The Wnt signaling pathway is involved in a wide range of embryonic patterning events and maintenance of homeostasis in adult tissues. The pathological role of the Wnt pathway has emerged from studies showing a high frequency of specific human cancers ...
Majid Shahana, Saini Sharanjot, Dahiya Rajvir   +2 more
doaj   +1 more source

Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signaling pathway

International Journal of Molecular Medicine, 2015
It is known that prolonged glucocorticoid (GC) treatment results in osteoporosis. This study aimed to evaluate the protective effects of curcumin on the bones of rats with dexamethasone (DXM)-induced osteoporosis.
Zhiguang Chen, Jinqi Xue, T. Shen, Shuai Mu, Q. Fu   +4 more
semanticscholar   +1 more source

A Novel Positive Feedback Loop Between NTSR1 and Wnt/β-Catenin Contributes to Tumor Growth of Glioblastoma

Cellular Physiology and Biochemistry, 2017
Background/Aims: Neurotensin (NTS), an intestinal hormone, is profoundly implicated in cancer progression through binding its primary receptor NTSR1. The conserved Wnt/β-Catenin pathway regulates cell proliferation and differentiation via activation of ...
Hualiang Xiao, Ying Zeng, Qiushi Wang, Shirong Wei, Xiangfeng Zhu   +4 more
doaj   +1 more source

miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway

eLife, 2014
MicroRNAs (miRNAs) are important regulators of stem and progenitor cell functions. We previously reported that miR-142 and miR-150 are upregulated in human breast cancer stem cells (BCSCs) as compared to the non-tumorigenic breast cancer cells.
Taichi Isobe, S. Hisamori, Daniel J. Hogan, M. Zabala, David G Hendrickson, P. Dalerba, S. Cai, F. Scheeren, Angera H. Kuo, Shaheen S. Sikandar, Jessica S. Lam, D. Qian, F. Dirbas, G. Somlo, K. Lao, P. Brown, M. Clarke, Y. Shimono   +17 more
semanticscholar   +1 more source

Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy. [PDF]

, 2019
The Wnt/β-catenin signaling pathway is an evolutionarily conserved developmental signaling event that plays a critical role in regulating tissue development and maintaining homeostasis, the dysregulation of which contributes to various diseases.
Chen, Lin, Liu, Dan, Ma, Shuang-Cheng, Vaziri, Nosratola D, Zhao, Hui, Zhao, Ying-Yong   +5 more
core  

Epigenetic silencing of SFRP1 and SFRP5 by hepatitis B virus X protein enhances hepatoma cell tumorigenicity through Wnt signaling pathway

International Journal of Cancer, 2014
Secreted frizzled‐related proteins (SFRPs) are antagonists of the Wnt signaling pathway whose epigenetic downregulation have been shown to be involved in hepatocarcinogenesis.
Qing Xie, Linlin Chen, X. Shan, X. Shan, Jia Tang, Fan Zhou, Qing-mei Chen, Hui-qin Quan, D. Nie, Wen‐lu Zhang, A. Huang, N. Tang   +11 more
semanticscholar   +1 more source

In vivo Activation of Wnt Signaling Pathway Enhances Cognitive Function of Adult Mice and Reverses Cognitive Deficits in an Alzheimer's Disease Model

Journal of Neuroscience, 2014
The role of the Wnt signaling pathway during synaptic development has been well established. In the adult brain, different components of Wnt signaling are expressed, but little is known about its role in mature synapses.
Jessica Y. Vargas, Marco Fuenzalida, N. Inestrosa   +2 more
semanticscholar   +1 more source

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

Genes and Diseases
The evolutionarily conserved Wnt signaling pathway plays a central role in development and adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling molecules that activate the canonical (β-catenin dependent) and non ...
Michael Yu, Kevin Qin, Jiaming Fan, Guozhi Zhao, Piao Zhao, Wei Zeng, Connie Chen, Annie Wang, Yonghui Wang, Jiamin Zhong, Yi Zhu, William Wagstaff, Rex C. Haydon, Hue H. Luu, Sherwin Ho, Michael J. Lee, Jason Strelzow, Russell R. Reid, Tong-Chuan He   +18 more
doaj  

New insights into the regulation of Axin function in canonical Wnt signaling pathway

Protein & Cell, 2014
The Wnt signaling pathway plays crucial roles during embryonic development, whose aberration is implicated in a variety of human cancers. Axin, a key component of canonical Wnt pathway, plays dual roles in modulating Wnt signaling: on one hand, Axin ...
Xiaomin Song, Sheng Wang, Lin Li
semanticscholar   +1 more source

Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin level [PDF]

, 1998
T. Nakamura, Fumihiko Hamada, Takao Ishidate, Ken‐ichi Anai, Kohichi Kawahara, Kumao Toyoshima, Tetsu Akiyama   +6 more
openalex   +1 more source