Results 101 to 110 of about 284,518 (203)

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

, 2019
The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years.
Aleithe, S., Brosch, M., Brusch, L., Damm, G., Gajowski, R., Gebhardt, R., Hampe, J., Hoehme, S., Hoffmann, U., Kolbe, E., Kücken, M., Matz-Soja, M., Meierhofer, D., Ott, F., Rennert, C., Schafmayer, C., Seehofer, D., Seifert, M., Spormann, L., Stöpel, C., von Schoenfels, W.   +20 more
core   +1 more source

Wnt Signalling Pathway Parameters for Mammalian Cells

PLoS ONE, 2012
Wnt/β-catenin signalling regulates cell fate, survival, proliferation and differentiation at many stages of mammalian development and pathology. Mutations of two key proteins in the pathway, APC and β-catenin, have been implicated in a range of cancers, including colorectal cancer. Activation of Wnt signalling has been associated with the stabilization
Tan, C.W., Gardiner, B.S., Hirokawa, Y., Layton, M.J., Smith, D.W., Burgess, A.W.   +5 more
openaire   +5 more sources

Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy. [PDF]

, 2019
The Wnt/β-catenin signaling pathway is an evolutionarily conserved developmental signaling event that plays a critical role in regulating tissue development and maintaining homeostasis, the dysregulation of which contributes to various diseases.
Chen, Lin, Liu, Dan, Ma, Shuang-Cheng, Vaziri, Nosratola D, Zhao, Hui, Zhao, Ying-Yong   +5 more
core  

Temporal Perturbation of the Wnt Signaling Pathway in the Control of Cell Reprogramming Is Modulated by TCF1

Stem Cell Reports, 2014
Cyclic activation of the Wnt/β-catenin signaling pathway controls cell fusion-mediated somatic cell reprogramming. TCFs belong to a family of transcription factors that, in complex with β-catenin, bind and transcriptionally regulate Wnt target genes ...
Francesco Aulicino, Ilda Theka, Luigi Ombrato, Frederic Lluis, Maria Pia Cosma   +4 more
doaj   +1 more source

The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape.

Trends in genetics : TIG, 2000
Members of the vertebrate Wnt family have been subdivided into two functional classes according to their biological activities. Some Wnts signal through the canonical Wnt-1/wingless pathway by stabilizing cytoplasmic beta-catenin. By contrast other Wnts stimulate intracellular Ca2+ release and activate two kinases, CamKII and PKC, in a G-protein ...
Kuhl, M., Sheldahl, L. C., Park, M., Miller, J. R., Moon, R. T.   +4 more
openaire   +2 more sources

Nanosilicates Enhanced Pdlscs Osteogenesis Via Activation Of Wnt/Β-Catenin Signaling

International Dental Journal
Aim or purpose: To explore the effects of nSi on PDLSCs-mediated periodontal tissue regeneration and investigate the potential involvement of Wnt/β-catenin signaling pathway.
Ziqin Chen, Luo Kai
doaj   +1 more source

Wnt Pathway-Targeted Therapy in Gastrointestinal Cancers: Integrating Benchside Insights with Bedside Applications

Cells
The Wnt signaling pathway is critical in the onset and progression of gastrointestinal (GI) cancers. Anomalies in this pathway, often stemming from mutations in critical components such as adenomatous polyposis coli (APC) or β-catenin, lead to ...
Anirudh Nayak, Hannah Streiff, Ivan Gonzalez, Oluwabomi Oluwatomi Adekoya, Itzcoatl Silva, Anitha Kota Shenoy   +5 more
doaj   +1 more source

Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances

Signal Transduction and Targeted Therapy
The Wnt signaling pathway is critically involved in orchestrating cellular functions such as proliferation, migration, survival, and cell fate determination during development.
Chen Xue, Qingfei Chu, Qingmiao Shi, Yifan Zeng, Juan Lu, Lanjuan Li   +5 more
doaj   +1 more source

Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk. [PDF]

, 2019
BackgroundThe development of an autistic brain is a highly complex process as evident from the involvement of various genetic and non-genetic factors in the etiology of the autism spectrum disorder (ASD). Despite being a multifactorial neurodevelopmental
Gu, Ran, Ji, Yu, Kumar, Santosh, Rai, Sunil, Reynolds, Kurt, Zhou, Chengji J   +5 more
core  

Manipulation of Wnt Signaling Pathway during Peripheral Nerve Regeneration. [PDF]

Cell Mol Neurobiol
Mehta N, Vardy M, Elbaz B.
europepmc   +1 more source