Results 91 to 100 of about 284,518 (203)

Differentiation Therapy Targeting the β-Catenin/CBP Interaction in Pancreatic Cancer. [PDF]

, 2018
BACKGROUND:Although canonical Wnt signaling is known to promote tumorigenesis in pancreatic ductal adenocarcinoma (PDAC), a cancer driven principally by mutant K-Ras, the detailed molecular mechanisms by which the Wnt effector β-catenin regulates such ...
Chen, Yibu, Genyk, Yuri S, Kahn, Michael, Lai, Keane KY, Lenz, Heinz-Josef, Lin, David P, Manegold, Philipp, Nguyen, Cu, Pandol, Stephen J, Teo, Jia-Ling, Wu, Kaijin, Wu, Yongfeng, Zhao, Yi   +12 more
core   +2 more sources

Deletion of a Single beta-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading [PDF]

, 2014
The Wnt/β-catenin signaling pathway is essential for bone cell viability and function and for skeletal integrity. To determine if β-catenin in osteocytes plays a role in the bone anabolic response to mechanical loading, 18- to 24-week-old osteocyte β ...
Akhter, Armstrong, Armstrong, Babij, Bodine, Bodine, Bonewald, Bouxsein, Boyden, Case, Choi, Dallas, Dempster, Diarra, Doube, Galea, Glass, Gong, Hens, Holmen, Holmen, Javaheri, Johnson, Johnson, Johnson, Kamel, Kato, Kitase, Korecki, Kramer, Lau, Li, Little, Logan, Lu, Monga, Nakashima, Nathke, Nusse, Pinson, Polakis, Reya, Robinson, Santos, Sawakami, Saxon, Schneider, Sen, Srivastava, Sunters, Wijenayaka, Xing, Xiong, Yao   +53 more
core   +2 more sources

Current perspectives of the signaling pathways directing neural crest induction. [PDF]

, 2012
The neural crest is a migratory population of embryonic cells with a tremendous potential to differentiate and contribute to nearly every organ system in the adult body.
García-Castro, Martín I, Stuhlmiller, Timothy J   +1 more
core   +2 more sources

Wnt Signaling Pathway Related Genes In Hepatocellular Carcinoma [PDF]

, 2002
Hepatocellular carcinoma (HCC) is an extremely difficult disease to manage and one of the ten most common cancers in Malaysia. However, the molecular mechanisms that contribute to tumour progression in hepatocarcinogenesis remain unknown.
Ban, Kechen
core  

MicroRNA roles in beta-catenin pathway [PDF]

, 2010
β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis.
Kai Huang, Jun-Xia Zhang, Lei Han, Yong-Ping You, Tao Jiang, Pei-Yu Pu, Chun-Sheng Kang   +6 more
core   +2 more sources

The Wnt signaling pathways and cell adhesion

Frontiers in Bioscience, 2012
In multicellular organisms, the processes of tissue and organ formation are governed by morphogenetic signaling pathways. The Wnt pathways regulate morphogenesis by controlling cell adhesion and migration; processes that when corrupted, lead to tumorgenesis.
Amin, N., Vincan, Elizabeth
openaire   +3 more sources

A Novel Positive Feedback Loop Between NTSR1 and Wnt/β-Catenin Contributes to Tumor Growth of Glioblastoma

Cellular Physiology and Biochemistry, 2017
Background/Aims: Neurotensin (NTS), an intestinal hormone, is profoundly implicated in cancer progression through binding its primary receptor NTSR1. The conserved Wnt/β-Catenin pathway regulates cell proliferation and differentiation via activation of ...
Hualiang Xiao, Ying Zeng, Qiushi Wang, Shirong Wei, Xiangfeng Zhu   +4 more
doaj   +1 more source

The WNT signalling pathway and diabetes mellitus [PDF]

Diabetologia, 2008
The WNT signalling pathway is involved in many physiological and pathophysiological activities. WNT ligands bind to Frizzled receptors and co-receptors (LDL receptor-related protein 5/6), triggering a cascade of signalling events. The major effector of the canonical WNT signalling pathway is the bipartite transcription factor beta-catenin/T cell ...
openaire   +2 more sources

Inhibitors of the Wnt pathway in osteoporosis: Mechanisms of action and potential as therapeutic targets

Biomolecules & Biomedicine
The Wnt signaling pathway is one of the most important and critical signaling pathways for maintaining cellular functions, such as cell proliferation and differentiation.
Jiayi Song, Weirong Chang, Yujie Wang, Peng Gao, Jie Zhang, Zhipan Xiao, Fangyu An, Chunlu Yan   +7 more
doaj   +1 more source

Wnt signal transduction pathway and apoptosis: a review

Cancer Cell International, 2010
The association between the wnt signaling pathway and apoptosis has become more firmly established in the recent scientific literature. Many reports indicate that the wnt signaling pathway regulates apoptosis through a variety of mechanisms. The activity
Pećina-Šlaus Nives
doaj   +1 more source